Hippophae rhamnoides L. Leaves Extract Enhances Cell Proliferation and Neuroblast Differentiation through Upregulation of Intrinsic Factors in the Dentate Gyrus of the Aged Gerbil

Bai Hui Chen,Ji Hyeon Ahn,Joon Ha Park,In Hye Kim,Jeong-Hwi Cho,Jae-Chul Lee,Bich-Na Shin,Hyun-Jin Tae,Jung Hoon Choi,Yun Lyul Lee,Moo-Ho Won 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8

Iliococcygeus fixation compared with Abdominal sacral colpopexy to treat Uterine prolapse for Elderly patients

( Yun Jin Park ),( Mi Kyung Kong ),( Sang Wook Bai ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Iliococcygeus fixation(ICG) is known to have an equivalent treatment outcome on abdominal sacrocolpopexcy(ASC) for treatment of apical prolapse. The aim of this study was to investigate clinical outcome of ICG in comparison with ASC for uterine prolapse according to age. Methods: Medical records of patients who underwent ICG or ASC at Yonsei university hospital from 2005 to 2014 were reviewed. Patients were grouped into three groups according to age: 50 years of age (group A), 51 to 69 years of age (group B), and 70 years of age (group C). Primary outcome of this study was recurrence of pelvic organ prolapse (POP) evaluated by POP-Quantification system. Secondary outcome were hospital stay, duration of operation, blood loss in surgery, and complication of ICG and ASC. Results: During the study period, total 166 patients were enrolled in this study. 105 patients underwent ASC and 61 patients underwent ICG. By age group, group A consisted of 17 women and group B consisted of 101 women. Group C consisted of 48 women who were 70 years old patients. In baseline characteristics, the oldest age group(C) had high parity and great proportion of comorbidity including hypertension (p< 0.001). The proportion of patients who underwent ICG was gradually increased by age (11.8% vs 32.7% vs 54.2%, p=0.003). There was no difference of recurrence rate of POP between ICG and ASC group (p=0.076). Also, in ICG group, there was no difference of POP relapse rate 1year after surgery between group A, B and C (p >0.999). ASC group had longer operation time than ICG group (205 min vs 122 min). In oldest age group(C), patients who underwent ICG had smaller bleeding loss during operation (39.2ml vs 56.8ml), and had shorter hospital stay than patients who underwent ASC (7.0day vs 9.1day). Conclusion: Regardless age, ICG is equivalent procedure in treatment outcome of uterine prolapse compared to ASC. Furthermore, in elderly patients, ICG with vaginal hysterectomy is safer surgery than ASC with abdominal hysterectomy.

Salmonella Typhi 心筋炎 1例

裵錫救,朴敦相,李愚吉,金元徹,尹德鎭 金原出版 1975 小兒科 Vol.16 No.10

Long term clinical outcome of Simple Excision of Eroded Mesh with Vaginal Estrogen after Urogynecologic surgery

( Yun Jin Park ),( Mi Kyung Kong ),( Sang Wook Bai ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The aim of this study was to investigate long term clinical outcome of simple excision of eroded mesh with vaginal estrogen for patients with mesh erosion after urogynecologic surgery. Methods: Medical records of patients who underwent excision of eroded mesh in outpatient clinic at Yonsei university hospital from 2007 to 2017 were reviewed. The size of defect of vaginal mucosa was smaller than 0.5cm in all patients. Vaginal estrogen was applied after mesh excision and pelvic examination was done within 3 months after procedure. Complete remission (CR) of mesh erosion was defined as no mucosal defect and no eroded mesh in pelvic examination. Results: During the study period, total 13 patients underwent simple excision of erode mesh. In baseline characteristics, mean age at diagnosis of mesh erosion was 55 and mean parity was 2 (range: 1-5). All patients had symptoms related to mesh erosion including vaginal discharge, bleeding and dyspareunia (n= 5, 5, 1). The initial operations causing mesh erosion were abdominal sacrocolpopexy (n=6) and midurethral sling (n=5). Mean time to initial surgery to mesh erosion was 40 months (range: 3-129) and mean length of follow-up period was 51 months. After diagnosis of mesh erosion, patients were diagnosed with CR at an average of 101 days (range: 5-365). During follow-up period, recurrence of mesh erosion occurred to 6 patients (54.5%). Mean time to diagnosis of CR to relapse of mesh erosion was 39 months. All patients with recurrence of mesh erosion were also diagnosed with CR after excision of mesh and vaginal estrogen. None of the patients required further intervention. Conclusion: Long term follow-up results show that simple excision of eroded mesh with vaginal estrogen is safe and less invasive procedure to avoid surgery under general anesthesia. If patient is tolerable, small size of vaginal mesh erosion can be treated by simple excision with vaginal estrogen without further intervention.

급성 사구체신염 220예에 대한 임상적 추후 관찰

배석구,전세종,김병길,윤덕진 金原出版 1975 小兒科 Vol.16 No.4

조피볼락(Sebastes schlegeli) 치어의 배합사료 적정 공급률과공급횟수

이진혁 ( Jin Hyeok Lee ),김강웅 ( Kang Woong Kim ),이봉주 ( Bong Joo Lee ),박건현 ( Gun Hyun Park ),이준호 ( Jun Ho Lee ),윤현호 ( Hyeon Ho Yun ),배승철 ( Sung Chul Bai ) 한국수산과학회 2013 한국수산과학회지 Vol.46 No.6

Two feeding trials were conducted to investigate the effects of feeding rate and frequency on growth performance and body composition of juvenile Korean rockfish Sebastes schlegeli reared at 15.0±0.3°C. In the first trial, three replicate fish groups averaging 2.07±0.03 g were fed a commercial diet with one of seven different daily feeding rates: 1.00%, 2.00%, 2.50%, 2.75%, 3.00%,3.25%, and satiation (3.34%) based on body weight (BW). After four weeks of feeding, fish fed the 3% diet showed significantly higher weight gain (WG) and feed efficiency (FE) than fish that received the other feeding rates. In the second trial, the optimum feeding frequency was evaluated with three replicate fish groups averaging 2.04±0.03 g. Fish were fed a commercial diet at 2.87%BW with six different daily feeding frequencies: 2, 3, 4, 5, 7, or 9 meals. After four weeks of feeding, WG, specific growth rate, FE,and protein efficiency rate in fish fed 3 meals d-1 were significantly higher than those of fish fed 7 or 9 meals d-1. In both feeding trials,proximate composition of the entire body changed depending on the feeding rate or frequency. A broken-line regression analysis based on weight gain suggested that the optimum daily feeding rate and frequency for juvenile Korean rockfish at 15°C was 2.9%BW d-1 and 2?3 meals d-1, respectively.

수온별 조피볼락(Sebastes schlegeli) 치어의배합사료 적정 공급횟수

이진혁 ( Jin Hyeok Lee ),이봉주 ( Bong Joo Lee ),김강웅 ( Kang Woong Kim ),한현섭 ( Hyon Sob Han ),박건현 ( Gun Hyun Park ),이준호 ( Jun Ho Lee ),윤현호 ( Hyeon Ho Yun ),배승철 ( Sung Chul Bai ) 한국수산과학회 2013 한국수산과학회지 Vol.46 No.6

We conducted two feeding trials to investigate the optimal feeding frequency of juvenile Korean rockfish Sebastes schlegeli fed a commercial diet of expanded pellets containing 47.2% crude protein, 9.2% crude lipid, and 14.5% ash at two different water temperatures. In the first experiment, triplicate groups of 20 fish with an average weight of 2 g were fed an equal amount of diet (5.97%based on body weight) at one of six feeding frequencies (2, 3, 4, 5, 7, or 9 meals/day) for four weeks at 17.5˚C. After four weeks,we measured weight gain (WG), specific growth rate (SGR), feeding efficiency (FE), and protein efficiency ratio (PER). Fish fed diet five meals/day grew significantly better than those fed nine meals/day. The second experiment used identical experimental conditions and feeding regions, except the food ration was slightly less (5.92% based on body weight) and the water temperature was increased to 20˚C. After four weeks, we again measured WG, SGR, FE and PER. Fish fed seven meals/day grew significantly faster than those fed 2, 3, 4, or 9 meals/day. Whole-body protein levels in fish fed three meals/day was higher than those fed four meals/day in 17.5˚C water, but whole-body lipids in the fish fed four meals/day was higher than those fed two meals/day in 20˚C water. A second-order polynomial analysis based on WG suggested the optimal feeding frequency for juvenile Korean rockfish was five meals/day at 17.5˚C and six meals/day at 20˚C, indicating that fish reared in higher water temperature require higher feeding frequencies.

Postoperative urinary symptoms after transobturator tape in normal-weight compared with overweight and obese woman

( Hyun Jin Lee ),( Young Bin Won ),( Yun Jin Park ),( Mi Kyung Kong ),( Sang Wook Bai ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3

Objective To examine the clinical outcome of obesity in women who underwent the transobturator tape procedure for stress urinary incontinence and to compare postoperative urinary symptoms after transobturator tape surgery between normal-weight women and overweight and obese women. Methods We performed a retrospective cohort study of the risk of postoperative urinary symptoms, including recurrence after transobturator tape surgery, in normal-weight women compared with overweight and obese women at our institution from January 2009 through October 2011. We compared the body mass index (BMI) among the four groups. The primary outcome was the occurrence of postoperative urinary symptoms. Results Three hundred ten patients who underwent transobturator tape surgery were reviewed. At the 1-year follow-up, 281 women were analyzed: 89 (34%) normal-weight women, 78 (25%) overweight women, 101 (37%) obese 1 women, and 13 (3%) obese 2 women. There was a significant difference in the occurrence of postoperative urinary symptoms. They occurred in 3.4% (n=3) of normal-weight women, 5.1% (n=4) of overweight women, and 12.9% (n=13) of obese 1 women (P=0.038). The most common postoperative urinary symptom was frequent urination (n=14). There was a significant difference in leakage; it occurred in 1.1% (n=1) of normal-weight women, 3.9% (n=3) of overweight women, and 7.9% (n=8) of obese 1 women (P=0.139). Postoperative urinary symptoms were almost four times more likely to occur in obese 1 women than in normal-weight women. Conclusion Transobturator tape surgery seems effective regardless of BMI, but obese women had a higher occurrence of postoperative urinary symptoms than did normal-weight women.

임신 중기 원인불명 인간 융모성 성선자극호르몬치 상승 임신부의 임신 결과

이윤정(Yun Jung Lee),김세광(Se Kwang Kim),안은희(Eun Hee Ahn),이진우(Jin Woo Lee),권혜경(Hye Kyung Kwon),이창희(Chang Hee Lee),김영한(Young Han Kim),배상욱(Sang Wook Bai),박기현(Ki Hyun Park),양영호(Young Ho Yang),송찬호(Chan Ho Song 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Objective : Our purpose was to determine the association between unexplained elevation of maternal serum human chorionic gonadotropin (hCG) in the second trimester and adverse pregnancy outcomes. Material and methods : Between February 1995 and July 1999, we evaluated 1566 pregnant women who have underwent second trimester triple marker screening tests (alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin) and delivered at Severance Hospital, Yonsei Medical Center. Multiple pregnancies, abnormal fetal karyotypes, fetal anomalies, and abortions were excluded from the study. One hundred twenty-one women with hCG levels greater than 2.0 multiples of the median (MoM) were included in the study group while 1389 women with hCG levels less than 2.0 MoM served as the control group. Pregnancy outcomes were obtained from the delivery and neonatal records in our institution. Adverse pregnancy outcomes between the two groups were compared using chi-square test and Fisher's exact test. Results : Women with unexplained elevation of human chorionic gonadotropin levels were associated with statistically significant increased risks for preeclampsia, preterm delivery, and low birth weight (p<0.05). However, there were no significant differences between the study and control groups with respect to preterm premature rupture of membranes, abnormal fetal heart rate tracing, abruptio placentae, intrauterine fetal death, and neonatal death. Conclusion : An unexplained elevation in human chorionic gonadotropin level in the second trimester may increase the risk for preeclampsia, preterm delivery, and low birth weight but not for other adverse pregnancy outcomes such as preterm premature rupture of membranes, abnormal fetal heart rate tracing, intrauterine fetal death, or neonatal death.

Ethanol extract of <i>Oenanthe javanica</i> increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus

Chen, Bai Hui,Park, Joon Ha,Cho, Jeong Hwi,Kim, In Hye,Shin, Bich Na,Ahn, Ji Hyeon,Hwang, Seok Joon,Yan, Bing Chun,Tae, Hyun Jin,Lee, Jae Chul,Bae, Eun Joo,Lee, Yun Lyul,Kim, Jong Dai,Won, Moo-Ho,Kang Medknow PublicationsMedia Pvt Ltd 2015 Neural regeneration research Vol.10 No.2

<P><I>Oenanthe javanica</I> is an aquatic perennial herb that belongs to the <I>Oenanthe genus</I> in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glutamate-induced neurotoxicity. However, few studies regarding effects of <I>Oenanthe javanica</I> on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract of <I>Oenanthe javanica</I> on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 (an endogenous marker for cell proliferation) and doublecortin (a marker for neuroblast). Our results showed that <I>Oenanthe javanica</I> extract significantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was significantly increased in the dentate gyrus of the <I>Oenanthe javanica</I> extract-treated group compared with the control group. However, we did not find that vascular endothelial growth factor expression was increased in the <I>Oenanthe javanica</I> extract-treated group compared with the control group. These results indicate that <I>Oenanthe javanica</I> extract improves cell proliferation and neuroblast differentiation by increasing brain-derived neurotrophic factor immunoreactivity in the rat dentate gyrus.</P>