Sub Oriented Histograms of Local Binary Patterns for Smoke Detection and Texture Classification

( Feiniu Yuan ),( Jinting Shi ),( Xue Xia ),( Yong Yang ),( Yuming Fang ),( Rui Wang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.4

Local Binary Pattern (LBP) and its variants have powerful discriminative capabilities but most of them just consider each LBP code independently. In this paper, we propose sub oriented histograms of LBP for smoke detection and image classification. We first extract LBP codes from an image, compute the gradient of LBP codes, and then calculate sub oriented histograms to capture spatial relations of LBP codes. Since an LBP code is just a label without any numerical meaning, we use Hamming distance to estimate the gradient of LBP codes instead of Euclidean distance. We propose to use two coordinates systems to compute two orientations, which are quantized into discrete bins. For each pair of the two discrete orientations, we generate a sub LBP code map from the original LBP code map, and compute sub oriented histograms for all sub LBP code maps. Finally, all the sub oriented histograms are concatenated together to form a robust feature vector, which is input into SVM for training and classifying. Experiments show that our approach not only has better performance than existing methods in smoke detection, but also has good performance in texture classification.

Dietary Saponins of Sea Cucumber Ameliorate Obesity, Hepatic Steatosis, and Glucose Intolerance in High-Fat Diet–Fed Mice

Xiaoqian Hu,Zhaojie Li,Yong Xue,Jingfeng Wang,Yuming Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.10

Much attention has been focused on food components that may be beneficial in preventing lifestyle-related diseases. In this study, we investigated the effects of saponins of sea cucumber (SSC) on high-fat diet–induced obesity, insulin resistance, and fatty liver in mice. C57/BL6 mice were fed a high-fat diet, containing 0.03% SSC, or 0.1% SSC for 8 weeks. Both doses of SSC exhibited a weight-loss effect and significantly decreased adipose tissue weight, in both visceral and subcutaneous depots. Furthermore, 0.1% SSC treatment dramatically decreased the hepatic triglyceride and total cholesterol accumulation. Mice administrated with 0.1% SSC had significantly decreased serum glucose and insulin levels, lower homeostatic model assessment for insulin resistance index, and area under the blood glucose curve, suggesting that insulin sensitivity is enhanced by dietary SSC. Dietary SSC also prevented adipokine imbalance, by increasing adiponectin production and decreasing tumor necrosis factor alpha level caused by high-fat diet. Overall, these data demonstrate that SSC could improve certain metabolic parameters associated with obesity.

The Effects of Fucosylated Chondroitin Sulfate Isolated from Isostichopus badionotus on Antimetastatic Activity via Downregulation of Hif-1α and Hpa

Min He,Jingfeng Wang,Shiwei Hu,Yuming Wang,Changhu Xue,Hui Li 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.5

Fucosylated chondroitin sulfate (CHS) wasprepared from the sea cucumber Isostichopus badionotus(Ib-CHS), and the antimetastatic effect was studied usingcell adhesion, migration, invasion, chorioallntoic membrane(CAM), and reverse transcriptase-polymerase chain reaction(RT-PCR) assays. Ib-CHS remarkably suppressed proliferationof 95D cells, and inhibited adhesion, migration, and invasionof 95D cells in a dose-dependent manner. CAM assayresults suggested that Ib-CHS attenuates neovascularizationin the chick embryo. RT-PCR analyses revealed that Ib-CHS dramatically decreased expression of matrix metalloproteinase-2/9 (MMP-2/9), hypoxia-inducible factor (Hif-1α), heparanase (Hpa), and vascular endothelial growthfactor (VEGF), and increased expression levels of the tissueinhibitors of metalloproteinase-1/2 (TIMP-1/2), importantinhibitors of MMP-2/9. Ib-CHS markedly inhibited tumorgrowth, improved the metastatic foci occurrence rate, anddown-regulated expressions of Hif-1α, Hpa, and VEGF invivo. Ib-CHS exerted antimetastatic activities in vitro andin vivo.

Long-chain bases from Cucumaria frondosa inhibit adipogenesis and regulate lipid metabolism in 3T3-L1 adipocytes

Yingying Tian,Shiwei Hu,Hui Xu,Jingfeng Wang,Changhu Xue,Yuming Wang 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

This study aims to investigate anti-adipogenic effects of long-chain bases from Cucumaria frondosa (Cf-LCBs) in vitro. Results showed that Cf-LCBs inhibited adipocyte differentiation and the expressions of CCAAT/enhancer binding proteins (C/EBPs) and peroxisome proliferators-activated receptor γ (PPARγ). Cf-LCBs increased β-catenin mRNA and nuclear translocation and increased its target genes, cyclin D1 and c-myc. Cf-LCBs enhanced fizzled and lipoprotein-receptor-related protein5/6 (LRP5/6) expressions, whereas wingless-type MMTV integration site10b (WNT10b) and glycogen syntheses kinase 3β (GSK3β) remained unchanged. Cf-LCBs also reduced adipogenesis and recovered WNT/β-catenin signaling in the cells suffering from 21H7, a β-catenin inhibitor. In addition, Cf-LCBs decreased triglyceride content and the expressions of lipogenesis genes. Cf-LCBs increased FFA levels and the expressions of lipidolytic factors. Cf-LCBs promoted the phosphorylation of adenosinemonophosphate- activated protein kinase (AMPK) and acetyl-CoA carboxylase. These findings indicate that Cf-LCBs inhibit adipogenesis through activation of WNT/β-catenin signaling and regulate lipid metabolism via activation of AMPK pathway.

Long-chain bases from Cucumaria frondosa inhibit adipogenesis and regulate lipid metabolism in 3T3-L1 adipocytes

Tian, Yingying,Hu, Shiwei,Xu, Hui,Wang, Jingfeng,Xue, Changhu,Wang, Yuming 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

This study aims to investigate anti-adipogenic effects of long-chain bases from Cucumaria frondosa (Cf-LCBs) in vitro. Results showed that Cf-LCBs inhibited adipocyte differentiation and the expressions of CCAAT/enhancer binding proteins (C/EBPs) and peroxisome proliferators-activated receptor ${\gamma}(PPAR{\gamma})$. Cf-LCBs increased ${\beta}-catenin$ mRNA and nuclear translocation and increased its target genes, cyclin D1 and c-myc. Cf-LCBs enhanced fizzled and lipoprotein-receptor-related protein5/6 (LRP5/6) expressions, whereas wingless-type MMTV integration site10b (WNT10b) and glycogen syntheses kinase $3{\beta}(GSK3{\beta})$ remained unchanged. Cf-LCBs also reduced adipogenesis and recovered WNT/${\beta}-catenin$ signaling in the cells suffering from 21H7, a ${\beta}-catenin$ inhibitor. In addition, Cf-LCBs decreased triglyceride content and the expressions of lipogenesis genes. Cf-LCBs increased FFA levels and the expressions of lipidolytic factors. Cf-LCBs promoted the phosphorylation of adenosinemonophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase. These findings indicate that Cf-LCBs inhibit adipogenesis through activation of WNT/${\beta}-catenin$ signaling and regulate lipid metabolism via activation of AMPK pathway.

A Novel High Performance SOI LDMOS with Buried Stepped Gate Field Plate

Hongchao Hu,Hongli Dai,Luoxin Wang,Haitao Lyu,Yuming Xue,Tu Qian 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.6

With the continuous development of science and technology, the power semiconductor devices are becoming more and more extensive. A novel silicon-on-insulator (SOI) lateral double-diffused metal–oxide–semiconductor (LDMOS) has been proposed in this paper. The new device is mainly characterized by introducing a stepped gate field plate in the low-K dielectric buried layer (SGFP-LK). On the one hand, the stepped gate field plate introduces extra lateral electric field peaks, which makes the distribution of potential lines more uniform and improves the breakdown voltage (BV). Moreover, the stepped gate fi eld plate decreases the specific on-resistance ( R on,sp ) by a promoted depletion. On the other hand, different from the traditional buried oxygen layer, the low-K dielectric layer strengthens the vertical electric field and signifi cantly increases BV. Ultimately, compared with the conventional device (C-SOI LDMOS), the BV of the SGFP-LK LDMOS is dramatically enhanced by 107% and the R on,sp is reduced by 24.8%. Furthermore, the figure of merit is enhanced by 472%. In addition, the maximum lattice temperature of the SGFP-LK LDMOS is dropped by 23.1 K, which relieves self-heating effects to some extent.

Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells

Hongxia Che,Lei Du,Peixu Cong,Suyuan Tao,Ning Ding,Fengjuan Wu,Changhu Xue,Jie Xu,Yuming Wang 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.4

Alzheimer's disease (AD) is a neurodegenerative disorder. Emerging evidence implicates β-amyloid (Aβ) plays a critical role in the progression of AD. In this study, we investigated the protective effect of cerebrosides obtained from sea cucumber against senescence-accelerated mouse prone 8 (SAMP8) mice in vivo. We also studied the effect of cerebrosides on Aβ-induced cytotoxicity on the rat pheochromocytoma cell (PC12) and the underlying molecular mechanisms. Cerebrosides ameliorated learning and memory deficits and the Aβ accumulation in demented mice, decreased the content of malondialdehyde (MDA), 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-hydroxy-2′-deoxyguanosine (8-oxo-G), and nitric oxide (NO), and enhanced the superoxide dismutase (SOD) activity significantly. The neuroprotective effect of sea cucumber cerebrosides (SCC) was also verified in vitro: the cerebrosides increased the survival rate of PC12 cells, recovered the cellular morphology, downregulated the protein levels of Caspase-9, cleaved Caspase-3, total Caspase-3, and Bax, and upregulated the protein level of Bcl-2, revealing that cerebrosides could inhibit Aβ-induced cell apoptosis. The results showed the protective effect of SCC was regulated by the mitochondria-dependent apoptotic pathway. Our results provide a new approach to developing the marine organisms as functional foods for neuroprotection.