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Equivalency of Series-Parallel Hybrid System Using Planetary Gear and Hybrid System Using EVT
Yuki Kubo,Satoshi Ogasawara,Masatsugu Takemoto 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
The series-parallel hybrid system using a planetary gear realizes low-fuel consumption and restraining of the exhaust gas by performing an optimal control of the internal combustion engine (ICE) with various driving modes. On the other hand, the hybrid system using electric variable transmission (EVT) has been proposed. This paper presents a theoretical consideration on equivalency of the series-parallel hybrid system and the hybrid system using the EVT. Additionally, some experimental results and simulation results are compared to confirm equivalency of the two systems.
Tomokazu Kubo,Sho Yuki 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Some leading manufactures vertically integrate wholesale functions in order to control those functions. Based on transaction cost analysis (TCA) and capability approach, this research proposes a conceptual framework why manufactures integrate wholesale functions or not. Specifically, it is suggested that human asset specificity and teachability positively related with vertical integration, while outside wholesaler know-how negatively related with vertical integration. Empirical analysis shows that decision on integration of wholesale functions are influenced by TCA and capability factors.
Electron compound nature in a surface atomic layer of a two-dimensional hexagonal lattice
Matsuda, Iwao,Nakamura, Fumitaka,Kubo, Keisuke,Hirahara, Toru,Yamazaki, Shiro,Choi, Won Hoon,Yeom, Han Woong,Narita, Hisashi,Fukaya, Yuki,Hashimoto, Mie,Kawasuso, Atsuo,Ono, Masanori,Hasegawa, Yukio,H American Physical Society 2010 Physical review. B, Condensed matter and materials Vol.82 No.16
Gao Botao,Sakaguchi Katsuhisa,Ogawa Tetsuya,Kagawa Yuki,Kubo Hirotsugu,Shimizu Tatsuya 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.2
BACKGROUND: Ballooned hepatocytes (BH) are a key histological hallmark of nonalcoholic steatohepatitis (NASH), yet their consequences for liver-specific functions are unknown. METHODS: In our previous study, an experimental model of human induced-BHs (iBH) has been successfully developed based on cell sheet technology. This study aimed to determine the functions of iBHs in the primary human hepatocyte/normal human dermal fibroblast (PHH/NHDF) co-culture cell sheets. Normal hepatocytes in the PHH/3T3-J2 co-culture cell sheets were set as a control, since 3T3-J2 murine embryonic fibroblasts have exhibited previously long term maintenance of PHH functions. RESULTS: It was found that, albumin secretion was not affected in iBHs, but urea synthesis as well as cytochrome P450 enzyme (CYP) activities including CYP1A2 and CYP3A4, were significantly reduced in iBHs. Besides, loss of bile canaliculi was observed in iBHs. These findings are consistent with clinical studies of human NASH. In addition, PHH/NHDF cell sheets demonstrated two fold higher TGF-β1 secretion compared with PHH/3T3-J2 cell sheets. Furthermore, treatment with a TGF-β inhibitor and a semi-synthetic bile acid analogue (obeticholic acid, phase 3 trial of NASH therapy) ameliorated the histological appearance of established iBHs. CONCLUSION: In summary, this study demonstrates the priority of iBHs in recapitulating not only histology but also clinically relevant hepatic dysfunctions in human NASH and suggests TGF-β and bile acid related signal pathway may play important roles in the formation of iBHs. BACKGROUND: Ballooned hepatocytes (BH) are a key histological hallmark of nonalcoholic steatohepatitis (NASH), yet their consequences for liver-specific functions are unknown. METHODS: In our previous study, an experimental model of human induced-BHs (iBH) has been successfully developed based on cell sheet technology. This study aimed to determine the functions of iBHs in the primary human hepatocyte/normal human dermal fibroblast (PHH/NHDF) co-culture cell sheets. Normal hepatocytes in the PHH/3T3-J2 co-culture cell sheets were set as a control, since 3T3-J2 murine embryonic fibroblasts have exhibited previously long term maintenance of PHH functions. RESULTS: It was found that, albumin secretion was not affected in iBHs, but urea synthesis as well as cytochrome P450 enzyme (CYP) activities including CYP1A2 and CYP3A4, were significantly reduced in iBHs. Besides, loss of bile canaliculi was observed in iBHs. These findings are consistent with clinical studies of human NASH. In addition, PHH/NHDF cell sheets demonstrated two fold higher TGF-β1 secretion compared with PHH/3T3-J2 cell sheets. Furthermore, treatment with a TGF-β inhibitor and a semi-synthetic bile acid analogue (obeticholic acid, phase 3 trial of NASH therapy) ameliorated the histological appearance of established iBHs. CONCLUSION: In summary, this study demonstrates the priority of iBHs in recapitulating not only histology but also clinically relevant hepatic dysfunctions in human NASH and suggests TGF-β and bile acid related signal pathway may play important roles in the formation of iBHs.