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RISS 인기검색어
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- 저자 : Yuhao Sun (검색결과 4 건)
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Yuhao Sun,Yaru Hu,Danqi Hu,Zhuqian Xiao,Hongpeng Wang,Jun Huang,Jian-wei Mao 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.14
Three different Akebia trifoliata fruit juices were prepared, and their effects on modulation of human fecal microbiota were elucidated through an anaerobic fermentation in vitro. Results indicated that the introduction of inoculatedly-fermented Akebia trifoliata fruit juice promoted short-chain fatty acids productivity. Fecal microbiota analysis demonstrated up-regulations for abundances of Limosilactobacillus, Megamonas, Bifidobacterium, and Escherichia_Shigella, and down-regulations for numbers of Bacteroides, Prevotella_9, Parasutterella, and Sutterella. Correlation analysis confirmed relationships among sample components, short-chain fatty acids productivity, and microbial abundances, suggesting that sugars and organic acids stimulated growth of Actinobacteriota and suppressed proliferation of Proteobacteria, thus uncovering the underlying mechanism for the better ability of inoculatedly-fermented Akebia trifoliata fruit juice to regulate microbiota structure. Besides, clusters of orthologous groups of proteins analysis indicated that metabolite biosynthesis, energy metabolism, homeostasis maintenance and other physiological functions were ameliorated.
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Sandwich Structure Electrode as Advanced Performance Anode for Lithium-Ion Batteries
Wei Chengcheng,Sun Xiaogang,Liang Guodong,Huang Yapan,Hu Hao,Xu Yuhao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.10
In this work, a sandwich structure electrode was prepared by a simple vacuum filtration and rolling process. The SEM showed that the active materials were uniformly embedded in the pores of the three-dimensional conductive network of the carbon nanotube (CNTs) conductive paper. The contact interface area of active material and the conductive network significantly increased and the interface resistance was greatly reduced. The porous anode can accommodate the volume expansion of the silicon and effectively alleviated pressed during cycle. The electrode also exhibited good stability in cycles. Electrochemical tests showed that the first discharge specific capacity of the sandwich electrode reached 2330 mAh/g with a coulombic efficiency of 86%. After 500 cycles, the specific capacity was still maintained at 1512 mAh/g. At a large current density of 2 A/g, the specific capacity hold was 840 mAh/g compared with the copper foil electrode of 100 mAh/g.
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Design and Testing of a Mechanical Power Take-off System for Rolling-type Wave Energy Converter
Yichen Jiang,Yuhao Peng,Yuan Sun,Zhi Zong,Lei Sun 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.5
Salter’s Duck can convert wave energy to mechanical energy with high efficiency up to 90%. The limitations and challenges in the usage of Salter’s Duck for energy production include preventing hydraulic system from the risk of leaking hydraulic oil and removing complex huge fixed bracket. This paper presents the conceptual design and an experimental investigation of a mechanical power-take-off (PTO) system for the floating Salter’s Duck. The PTO system is fully installed inside of the Salter’s Duck. It consists of double counter-rotating flywheels converting the bi-directional rotation of the wave energy converter into a stable unidirectional rotation that drives a rotary generator to produce electricity. The bi-to-unidirectional function is achieved through inertial wheels, thus the novel PTO system is free of large supporting structures and hydraulic cylinders. In this paper, a detailed conceptual PTO design is proposed firstly. Further, the influence of the swing amplitude and rotation period of the wave energy converter on the power extraction efficiency is investigated. Then, the influence of the electrical load on the power-extraction efficiency is researched. In the end, the effect of the speed increasing ratio on the mechanical efficiency is examined. The experimental results show that the new type of generator mechanism can produce electricity stably.
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Lin Jialiang,Wang Longjie,Wu Yuhao,Xiang Qian,Zhao Yongzhao,Zheng Xuanqi,Jiang Shuai,Sun Zhuoran,Fan Dongwei,Li Weishi 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Intervertebral disc degeneration (IDD) is an important pathological basis for degenerative spinal diseases and is involved in mitophagy dysfunction. However, the molecular mechanisms underlying mitophagy regulation in IDD remain unclear. This study aimed to clarify the role of DJ-1 in regulating mitophagy during IDD pathogenesis. Here, we showed that the mitochondrial localization of DJ-1 in nucleus pulposus cells (NPCs) first increased and then decreased in response to oxidative stress. Subsequently, loss- and gain-of-function experiments revealed that overexpression of DJ-1 in NPCs inhibited oxidative stress-induced mitochondrial dysfunction and mitochondria-dependent apoptosis, whereas knockdown of DJ-1 had the opposite effect. Mechanistically, mitochondrial translocation of DJ-1 promoted the recruitment of hexokinase 2 (HK2) to damaged mitochondria by activating Akt and subsequently Parkin-dependent mitophagy to inhibit oxidative stress-induced apoptosis in NPCs. However, silencing Parkin, reducing mitochondrial recruitment of HK2, or inhibiting Akt activation suppressed DJ-1-mediated mitophagy. Furthermore, overexpression of DJ-1 ameliorated IDD in rats through HK2-mediated mitophagy. Taken together, these findings indicate that DJ-1 promotes HK2-mediated mitophagy under oxidative stress conditions to inhibit mitochondria-dependent apoptosis in NPCs and could be a therapeutic target for IDD.
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