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- 저자 : Yue Wenwen (검색결과 3 건)
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Hongliang Li,Yue Zhou,Yongqi Yang,Yiwen Zha,Bingqian Ye,Seo-Yeong Mun,Wenwen Zhuang,Jingyan Liang,Won Sun Park The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Voltage-dependent K<sup>+</sup> (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory effect of encainide, a class Ic anti-arrhythmic agent, on Kv channels of vascular smooth muscle from rabbit coronary arteries. Encainide inhibited Kv channels in a concentration-dependent manner with an IC<sub>50</sub> value of 8.91 ± 1.75 μM and Hill coefficient of 0.72 ± 0.06. The application of encainide shifted the activation curve toward a more positive potential without modifying the inactivation curve, suggesting that encainide inhibited Kv channels by altering the gating property of channel activation. The inhibition by encainide was not significantly affected by train pulses (1 and 2 Hz), indicating that the inhibition is not use (state)-dependent. The inhibitory effect of encainide was reduced by pretreatment with the Kv1.5 subtype inhibitor. However, pretreatment with the Kv2.1 subtype inhibitor did not alter the inhibitory effects of encainide on Kv currents. Based on these results, encainide inhibits vascular Kv channels in a concentration-dependent and use (state)-independent manner by altering the voltage sensor of the channels. Furthermore, Kv1.5 is the main Kv subtype involved in the effect of encainide.
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PVDF membrane with tea powder adhered for efficient separation of emulsified oil
Zhang Junshuang,Wu Yue,Xia Mengsheng,Yang Qijiang,Xu Qinyao,Feng Wenwen 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.10
Conventional oily wastewater treatment can remove slick oil and dispersed oil well, but it is difficult for it to remove emulsified oil. Nonetheless, the development of super wetting materials provides a key role in treating the emulsified oil, but there are some problems, such as expensive raw materials, complicated processes, as well as secondary pollution. In order to treat these problems, a brand-new oil/water separation membrane (TEA/PVDF membrane) was developed by combining the viscosity of sodium alginate (SA) and the filter tea powder (TEA) onto the surface of the polyvinylidene fluoride (PVDF) membrane by a vacuum pump. Furthermore, the underwater oleophobic angle reached 135o. Moreover, the oil-water separation experiments of oil-in-water emulsion utilizing TEA/PVDF membrane demonstrated excellent separation efficiency (99.6%) and good flux (254 L m−2 h−1 bar−1). Notably, upon ten cycles, the oil removal rate was still as high as 99.2%. Moreover, the TEA/PVDF membrane was able to separate oil-in-water emulsions in environments with strong acids, strong bases, and high salt concentrations, with a separation efficiency of over 95.9%. Such a novel oil/water separation membrane is economic, environmentally protective, and simple production process, which exhibits overwhelming potential in practical life for treating oily wastewater.
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Ultrasound-Guided Radiofrequency Ablation in Tertiary Hyperparathyroidism: A Prospective Study
Deng Erya,Jiang Tingting,Chai Huihui,Weng Ning,He Hongfeng,Zhang Zhengxian,Peng Chengzhong,Yue Wenwen,Xu Huixiong 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.3
Objective: To prospectively evaluate the outcomes of ultrasound (US)-guided radiofrequency ablation (RFA) in tertiary hyperparathyroidism (THPT). Materials and Methods: Patients with THPT underwent RFA between September 2017 and January 2022. Laboratory parameters, including serum intact parathyroid hormone (iPTH) levels, were monitored for 48 months after RFA and compared with the levels at baseline. Complications related to RFA and changes in hyperparathyroidism-related clinical symptoms were recorded before and after RFA. Results: A total of 42 patients with THPT were recruited for this study. Ultimately, 36 patients with renal failure and 2 patients who underwent successful renal transplantation (male:female, 17:21; median age, 54.5 years) were enrolled. The follow-up time was 21.5 ± 19.0 months in the 36 patients with renal failure. In these 36 patients, iPTH levels were significantly decreased to 261.1 pg/mL at 48 months compared with the baseline value of 1284.9 pg/mL (P = 0.012). Persistent hyperparathyroidism, defined as iPTH levels maintained at > 585.0 pg/mL for 6 months after treatment, occurred in 4.0% of patients (1/25). Recurrent hyperparathyroidism, defined as iPTH levels > 585.0 pg/mL after 6 months, were 4.0% (1/25) and 0.0% (0/9) at 6 months and 4 years after treatment, respectively. In two patients with THPT after successful renal transplantation, iPTH decreased from the baseline value of 242.5 and 115.9 pg/mL to 171.0 and 62.0 pg/mL at 6 months after treatment. All complications resolved within 6 months of ablation without medical intervention, except in 10.5% (4/38) patients with permanent hypocalcemia. The overall symptom recovery rate was 58.8% (10/17). The severity scores for bone pain, arthralgia, and itchy skin associated with hyperparathyroidism improved after treatment (P < 0.05). Conclusion: US-guided RFA is an effective and safe alternative to surgery in the treatment of patients with TPTH and improves hyperparathyroidism-related clinical symptoms.
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