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Cellulase from the fruiting bodies and mycelia of edible mushrooms : A review
Yuanzheng Wu,Hyun-Jae Shin 한국버섯학회 2016 한국버섯학회지 Vol.14 No.4
Cellulose is the most abundant organic polymer constituent of the cell wall of green plants and of various forms of algae. The complexity of lignocellulosic biomass is a major challenge in industrial research. Most mushroom species that naturally grow on soil or wood possess cellulases and the corresponding enzymatic system and, potential candidates for the direct bioconversion of softwood polysaccharides into fermentable sugars. However, there have been fewer studies on mushroom cellulases than on fungi such as Trichoderma spp., exploit the full potential of mushroom cellulases. This review will focus on the current status ofmushroom cellulase research and applications and will provide insight into promising future prospects.
Fungal and mushroom hydrophobins: A review
Wu, Yuanzheng,Li, Jishun,Yang, Hetong,Shin, Hyun-Jae The Korean Society of Mushroom Science 2017 한국버섯학회지 Vol.15 No.1
Hydrophobins are surface active proteins that are produced by filamentous fungi including mushrooms. Their ability to self-assemble into an amphipathic membrane at any hydrophilic-hydrophobic interface is most intriguing. These small secreted proteins comprise of eight conserved cysteine residues which form four disulfide bridges and an extraordinary hydrophobic patch. Hydrophobins play critical roles in fungal (and/or mushrooms) growth as structural components and in the interaction of fungi and mushrooms with the environment. The biophysical and biochemical properties of the isolated proteins are remarkable, such as strong adhesion, high surface activity and the formation of various self-assembled structures. With the increasing demands of hydrophobins from fungi and mushroom sources, production and purification in large scale is under challenge. Various applications, ranging from food industries, cosmetics, nanotechnology, biosensors and electrodes, to biomaterials and pharmaceuticals are emerging and a bright future is foreseen.
Cellulase from the fruiting bodies and mycelia of edible mushrooms: A review
Wu, Yuanzheng,Shin, Hyun-Jae The Korean Society of Mushroom Science 2016 한국버섯학회지 Vol.14 No.4
Cellulose is the most abundant organic polymer constituent of the cell wall of green plants and of various forms of algae. The complexity of lignocellulosic biomass is a major challenge in industrial research. Most mushroom species that naturally grow on soil or wood possess cellulases and the corresponding enzymatic system and, potential candidates for the direct bioconversion of softwood polysaccharides into fermentable sugars. However, there have been fewer studies on mushroom cellulases than on fungi such as Trichoderma spp., exploit the full potential of mushroom cellulases. This review will focus on the current status ofmushroom cellulase research and applications and will provide insight into promising future prospects.
Development of Cosmetic Products using Mushrooms
Yuanzheng Wu,Moon-Hee Choi,Hyun-JaeShin 한국버섯학회 2017 버섯 Vol.21 No.2
Mushrooms have been valued as a traditional source of natural bioactive compounds for centuries and have recently been exploited for potential components in cosmetics industry. Numerous mushrooms and their ingredients have been known to be beneficial to the skin and hair. The representative ingredients are as follows: phenolics, polyphenolics, terpenoids, selenium, polysaccharides, vitamins and volatile organic compounds. These compounds show excellent antioxidant, anti-aging, anti-wrinkle, skin whitening, and moisturizing effects which make them ideal candidates for cosmetics products. This review provides some perspectives of mushrooms (and/or extracts) and their ingredients presently used, or patented to be used, in both cosmeceuticals for topical administration and nutricosmetics for oral administration. With the small percentage of mushrooms presently identified and utilized, more mushroom species will be discovered, verified, and cultivated in the future, boosting the development of relevant industry. Combining with progress in genomics, proteomics, metabolomics, and systems pharmacology, mushrooms can find their way into cosmetics with multiple approaches.
Yuanzheng Wu,Hetong Yang,전영진,이민영,Jishun Li,신현재 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.4
A copper(I)-catalyzed azide-alkyne cycloaddition(CuAAC) reaction was exploited for the surface modificationof cowpea chlorotic mottle virus (CCMV). The exposedcarboxyl residues of the CCMV capsids were modifiedwith an alkyne and then further modified with an azide,using a triazole connection in the presence of CuSO4,tris(2-carboxyethyl)phosphine hydrochloride (TCEP), anda bathocuproin disulfonic acid disodium salt (BCDS). Fluorogenic coumarin was successfully grafted onto theCCMV capsids and monitored by fast protein liquidchromatography (FPLC) and UV-irradiated SDS-PAGE. An oligo-ethylene glycol (OEG) short chain and an Arg-Gly-Asp (RGD) peptide were also connected to the CCMVcapsids via the CuAAC reaction. Size-exclusion FPLC,transmission electron microscopy (TEM), and dynamiclight scattering (DLS) analyses confirmed the modificationand integrity of the viral capsids. Interestingly, OEG-CCMVdisplayed a unique phenomenon of connected bridges withthe intact capsids crosslinked to each other. Coumarin-CCMV, OEG-CCMV, and RGD-CCMV were absorbedonto APTES slides for cell binding with HeLa cells. Theopposite adhesion behavior of OEG-CCMV and RGDCCMVindicated the inhibition effect of OEG and thepromotion effect of RGD for cell attachment. This providesa generalized method for chemical modification of thesurface of virus capsids with multivalent ligands, whichdemonstrates the potential applications in bioimaging, tissueengineering, and drug delivery.
Yuanzheng Wu,Jishun Li,Hetong Yang,성지현,임호동,김근중,신현재 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.6
Our aim was to devise targeted drug delivery systems using genetically modified cowpea chlorotic mottle virus (CCMV) capsids by fusion expression with tumorhoming peptide F3 for efficient delivery of therapeutic substances into tumor cells. The RNA-binding domain at the N terminus (amino acid residues 1–25) of CCMV capsid protein (CP) was selectively deleted, and F3 was inserted for the expression in Pichia pastoris. After chromatographic purification, F3-CCMV capsids were obtained via selfassembly of the F3-CP fusion protein and then analyzed by transmission electron microscopy and dynamic light scattering analysis, which revealed spherical nanoparticles (NPs) ca. 18 nm in diameter with regular monodispersity. Near-infrared fluorescent dye IR780 iodide, which has been applied for cancer imaging, photodynamic therapy, and photothermal therapy, was encapsulated in F3-CCMV NPs. The resultant F3-CCMV-IR780 NPs showed excellent molecular targeting to nucleolin receptor overexpressed on the surface of MCF-7 tumor cells. Furthermore, the in vitro cellular uptake and cell viability assay proved a photothermal effect by a single dose of near-infrared laser irradiation. The present system may offer a programmable nanoscaffoldbased drug delivery system vehicle for fabrication of promising therapeutic substances for cancer therapy.