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      • KCI등재

        A Kind of Digital Intelligent System for the Ink Hue Analysis

        MinLin,Yuanhui Cui,YuRu Wang 한국멀티미디어학회 2007 멀티미디어학회논문지 Vol.10 No.6

        This paper introduces a kind of new ink hue analysis system (HAS) based on the model-distinguishing technology and briefly casts light on the principle of the analysis. Also, it stresses the hardware structure, the software designing methods and programming procedure of the HAS as well as its interface. And the simulation result of the experiment data was given. The study shows that this kind of system can help to improve the color arrangements and managements of ink. The accuracy has reached ±0.5% compared with high precision density meter.

      • KCI등재

        Ultrasensitive SERS-Based Immunoassay of Tumor Marker in Serum Using Au-Ag Alloy Nanoparticals and Ag/AgBr Hybrid Nanostructure

        Yongfeng Gao,Yuanhui Feng,Lu Zhou,Lucia Petti,Zhe Wang,Jun Zhou,Shusen Xie,Jian Chen,Yanping Qing 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.1

        Ultrasensitive detection of alpha-fetoprotein (AFP) is critical for the early diagnosis of liver cancer. In this work, a novel surface-enhanced Raman scattering (SERS)-based immunoassay complex has been successfully developed for the detection of AFP by using the Au-Ag alloy nanoparticals and the Ag/AgBr hybrid nanostructure. As the typical bimetal or metal/semiconductor plasmonic materials, besides the strong SERS enhancement characteristics, the Au-Ag alloy nanoparticals exhibit excellent monodispersity and the Ag/AgBr hybrid nanostructure demonstrates good stability. The experimental results show that the SERS-based immunoassay of AFP presents a low limit of detection of 1.86 fg/mL and a broad dynamic range from 2 fg/mL to 0.8 g/mL. Furthermore, the clinical applicability of the proposed SERS-based immunoassay has been assessed by the detection of AFP in the human serum samples of cancer patient and healthy person. The test data are consistent well with that of chemiluminescence immunoassay (CLIA) in the relative errors of –8.82–8.06% and show better detection sensitivity. It reveals that the proposed immunoassay protocol is significant for giving insight into the design of ultrasensitive biosensor and the point-of-care testing of cancers.

      • KCI등재

        Robust Adaptive Dynamic Surface Control Based on Structural Reliability for a Turret-moored Floating Production Storage and Offloading Vessel

        Yulong Tuo,Yuanhui Wang,Simon X. Yang,Mohammad Biglarbegian,Mingyu Fu 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4

        For floating production storage and offloading (FPSO) vessels, a dynamic positioning controller is necessary because using only a mooring system is not possible to keep the ship within a predefined region. Position control of the FPSO vessel is extremely challenging due to model uncertainties and unknown control coefficients. This paper develops a new robust adaptive positioning controller consisting of several components: adaptive law, dynamic surface control (DSC) technology, sigmoid tracking differentiator (STD), Nussbaum gain function, and structural reliability index. Model uncertainties can be estimated by the adaptive law derived from the Lyapunov theory. The DSC technology is used to eliminate repeated differentiation by introducing first-order filtering of the virtual control. The chattering-free STD with the characteristics of global fast convergence can estimate the derivatives of model uncertainties that are difficult to calculate directly. Therefore, the DSC and STD techniques make the proposed controller simpler to compute and easier to implement in engineering practice. Most of the traditional controllers require the information about the control coefficients to guarantee the stability of the closed-loop system while the Nussbaum gain function can remove the requirement for a priori knowledge of the sign of control coefficients. The capacity of the mooring system can be fully utilized to position the FPSO vessel by adjusting the structural reliability index on the premise of ensuring the safety of mooring lines, and hence less control effort is needed for the positioning controller. Simulations using two sets of system parameters demonstrate the proposed controller’s effectiveness. In addition, a qualitative comparison with the adaptive backstepping controller shows that our proposed controller is computationally more efficient and does not require a priori knowledge of the sign of control coefficients. A quantitative comparison with robust adaptive controller without the structural reliability shows that less control effort is needed using our proposed controller.

      • KCI등재

        A Kind of Digital Intelligent System for the Ink Hue Analysis

        Lin, Min,Cui, Yuanhui,Wang, Yu Ru Korea Multimedia Society 2007 멀티미디어학회논문지 Vol.10 No.6

        This paper introduces a kind of new ink hue analysis system (HAS) based on the model-distinguishing technology and briefly casts light on the principle of the analysis. Also, it stresses the hardware structure, the software designing methods and programming procedure of the HAS as well as its interface. And the simulation result of the experiment data was given. The study shows that this kind of system can help to improve the color arrangements and managements of ink. The accuracy has reached ${\pm}0.5%$ compared with high precision density meter.

      • KCI등재

        Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen athway in preeclampsia

        Xiang-Hong Xu,Yuanhui Jia,Xinyao Zhou,Dandan Xie,Xiaojie Huang,Linyan Jia,Qian Zhou,Qingliang Zheng,Xiangyu Zhou,Kai Wang,Li-Ping Jin 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

        Preeclampsia is a pregnancy-specific disorder that is a major cause of maternal and fetal morbidity and mortality with a prevalence of 6–8% of pregnancies. Although impaired trophoblast invasion in early pregnancy is known to be closely associated with preeclampsia, the underlying mechanisms remain elusive. Here we revealed that lysyl oxidase (LOX) and LOX-like protein 2 (LOXL2) play a critical role in preeclampsia. Our results demonstrated that LOX and LOXL2 expression decreased in preeclamptic placentas. Moreover, knockdown of LOX or LOXL2 suppressed trophoblast cell migration and invasion. Mechanistically, collagen production was induced in LOX- or LOXL2-downregulated trophoblast cells through activation of the TGF-β1/Smad3 pathway. Notably, inhibition of the TGF-β1/Smad3 pathway could rescue the defects caused by LOX or LOXL2 knockdown, thereby underlining the significance of the TGF-β1/ Smad3 pathway downstream of LOX and LOXL2 in trophoblast cells. Additionally, induced collagen production and activated TGF-β1/Smad3 were observed in clinical samples from preeclamptic placentas. Collectively, our study suggests that the downregulation of LOX and LOXL2 leading to reduced trophoblast cell migration and invasion through activation of the TGF-β1/Smad3/collagen pathway is relevant to preeclampsia. Thus, we proposed that LOX, LOXL2, and the TGF-β1/Smad3/collagen pathway can serve as potential markers and targets for clinical diagnosis and therapy for preeclampsia.

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