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Harmine Induces Apoptosis of HepG2 Cell via Mitochondrial Signaling Pathway
( Heng Yu ),( Yan Ping Zhang ) 조선대학교 공학기술연구원 2011 공학기술논문지 Vol.4 No.3
Harmine exhibited a strong inhibitory effect on the grow고 and proliferation of HepG2 cell line in a dose dependent manner. Hoechest 33258 staining revealed that the nuclear fragmentation, chromosomal cells, condensed shrank and were appeared in the HepG2 treated with Harmine. The percentage of the sub/G1 fraction was increased in a concentration dependent manner, indicating that the apoptotic cell death. PI staining experiment showed that Harmine was HepG2 cell change the cell cycle distribution of HepG2, cell and decreased the proportion of cells in G0-G1 phase. Although, increased the proportion of S phase cells and G2-M phase cells. Harmine induced apoptosis in HepG2 cells in a concentration dependent manner, with occurrence rates of apoptotic cells of 20.00%, 32.70% and 64.90%, respectively. JC-1 showed a decrease in mitochondrial membrane potential. Apoptosis of HepG2 cells was associated with Caspase-3 and Caspase-9 activation. down-regulation of Bcl-2, Mcl-1, Bcl-x1 and n -change of Bax. It seems that Harmine exhibited an anti-proliferative effect in HepG2 cells via mitochondrial signal pathways. The cancer-specific selectivity have shown in this study. suggested that Harmine could be a promising novel drug for human hepatocellular carcinoma.
MyEvalvid_RTP: a Evaluation Framework for More Realistic Simulations of Multimedia Transmission
Chia-Yu Yu,Chih-Heng Ke,Reuy-Shin Chen,Ce-Kuen Shieh,Naveen Chilamkurti 보안공학연구지원센터 2008 International Journal of Software Engineering and Vol.2 No.2
Recently, multimedia is a more and more important Internet service. For multimedia, Quality of service (QoS) support is a crucial requirement. To meet these QoS requirements, researchers develop specific multimedia mechanism to enhance the performance of video transmission. When they evaluate the performance of their mechanism, most researchers use simulation tools to evaluate. However, when using these simulation tools, researchers usually acquire network-level performance metrics, such as throughput. They cannot evaluate video and audio delivered quality by comparing the original and distorted video. However, using network-level performance metrics can not evaluate the delivered quality correctly. To address this issue, some esearchers proposed simulation tool-sets. These simulation tool-sets can evaluate the video delivered quality well. However, they cannot evaluate the audio delivered quality. Therefore, we propose a new simulation tool-set called as MyEvalvid_RTP to achieve more realistic simulations in this paper. By MyEvalvid_RTP, researchers can evaluate both the video delivered quality and the audio delivered quality.
Chen, Yu-Chih,Baac, Hyoung Won,Lee, Kyu-Tae,Fouladdel, Shamileh,Teichert, Kendall,Ok, Jong G.,Cheng, Yu-Heng,Ingram, Patrick N.,Hart, A. John,Azizi, Ebrahim,Guo, L. Jay,Wicha, Max S.,Yoon, Euisik American Chemical Society 2017 ACS NANO Vol.11 No.5
<P>Considerable evidence suggests that self-renewal and differentiation of cancer stem-like cells, a key cell population in tumorgenesis, can determine the outcome of disease. Though the development of microfluidics has enhanced the study of cellular lineage, it remains challenging to retrieve sister cells separately inside enclosed microfluidics for further analyses. In this work, we developed a photomechanical method to selectively detach and reliably retrieve target cells from enclosed microfluidic chambers. Cells cultured on carbon nanotube polydimethylsiloxane composite surfaces can be detached using shear force induced through irradiation of a nanosecond-pulsed laser. This retrieval process has been verified to preserve cell viability, membrane proteins, and mRNA expression levels. Using the presented method, we have successfully performed 96-plex single-cell transcriptome analysis on sister cells in order to identify the genes altered during self-renewal and differentiation, demonstrating phenomenal resolution in the study of cellular lineage.</P>
Association between Pax8-PPARγ1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis
Li, Hang-Yu,Xie, Zhi-Hao,Xu, Cong-Hui,Pu, Mei-Ling,Chen, Zi-Yan,Yu, Miao,Wang, Heng-Shu,Zhou, Chen-Ming,Pu, Chao-Yu,Liu, Wei Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-$PPAR{\gamma}1$) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- $PPAR{\gamma}1$ rearrangement. In order to have a better understanding of the association between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-$PPAR{\gamma}1$ rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-$PPAR{\gamma}1$ rearrangement has significant association with follicular thyroid cancer.
Jonathan YJ Chen,Han-Yu Tsai,Chen-Pang Hou,Shu-Han Tsao,Yu-Ting Chen,Horng-Heng Juang,Yu-Hsiang Lin 대한비뇨의학회 2024 Investigative and Clinical Urology Vol.65 No.5
Purpose: To investigate the relationship between prostatic urethral angle (PUA) and the development of surgical capsule calculi (SCC) within the prostate, and to examine the presence and impact of intravesical prostatic protrusion (IPP). Materials and Methods: A retrospective analysis was conducted on 90 patients who underwent radical prostatectomy, with preoperative assessments using both transrectal ultrasound of the prostate (TRUS) and magnetic resonance imaging. Patients were divided into groups with and without SCC and further categorized into type 1 and type 2 stones based on the location and severity of the calculi. Statistical analysis included chi-square and independent sample t-tests, with p<0.05 considered significant. Results: Of the patients, 82.2% were diagnosed with SCC. No significant difference in PUA was found between patients with and without SCC. However, a notable disparity in IPP presence was observed, suggesting an inverse correlation with SCC development. Additionally, no significant differences were identified when comparing the two types of SCC based on PUA and IPP measurements. Conclusions: The presence of IPP exhibited an inverse relationship with SCC, suggesting diminished urine flow pressure over the prostatic urethra may reduce the likelihood of SCC formation. However, no direct association between PUA and the presence or severity of SCC was identified. These findings highlight the complexity of factors contributing to prostatic calculi development and the potential role of IPP in this context.