http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Outcomes of surgical and nonsurgical treatment for colorectal cancer in nonagenarian patients
Youngbae Jeon,Kyoung-Won Han,Won-Suk Lee,Jeong-Heum Baek 대한종양외과학회 2021 대한임상종양학회 학술대회지 Vol.2021 No.6
Background/Aims Human life expectancy has dramatically increased over a few centuries. As the era of super-aging approaches, the proportion of patients aged >90 years who are highly exposed to various diseases, including colorectal cancer, is also increasing. Although surgery is the essential treatment with curative intent for primary colorectal cancer, there are still concerns to perform major surgery under general anesthesia for extremely old patients due to clinical demands. This study is aimed to evaluated the clinical outcomes of surgical treatment for nonagenarian patients with colorectal cancer. Methods This retrospective single-center study included patients diagnosed with colorectal cancer at the age of ≥90 years between 2004 and 2018. Patient demographics were compared between the operation and nonoperation groups. Perioperative outcomes, histopathological outcomes, and postoperative complications were evaluated. Overall survival was analyzed using Kaplan–Meier methods and log-rank test. Results A total of 31 patients were included (16 men, 15 women), and the median age was 91 (range: 90–96) years. The number of patients who underwent surgery and who received nonoperative management was 20 and 11, respectively. No statistical differences in baseline demographics were observed between both groups. None of these patients were treated with perioperative chemotherapy or radiotherapy. Surgery comprised of 18 (90.0%) colectomies, and 2 (10.0%) transanal excisions. Short-term (≤30 days) and long-term (31–90 days) postoperative complications occurred in 7 (35.0%) and 4 (20.0%) patients, respectively. No complications needed reoperation, such as anastomosis leakage or bleeding. No postoperative mortality occurred within 30 days: 90-day postoperative mortality occurred in two patients (10.0%), respectively. The median overall survival of the operation group was 31.6 (95% confidence interval [CI]: 26.7–36.5) and that of nonoperation group was 12.5 months (95% CI: 2.4–22.6) (p = 0.012). Conclusions Surgical treatment can be considered in carefully selected nonagenarian patients with colorectal cancer in terms of acceptable postoperative morbidity, with better overall survival than the nonsurgical treatment.
Youngbae Jeon,Kyoung-Won Han,이석호,Sun Jin Sym,최승준,하승연,백정흠 대한종양외과학회 2021 Korean Journal of Clinical Oncology Vol.17 No.2
Purpose: Curative treatment is challenging in patients with locally advanced rectal cancer and unresectable metastases. The aim of this study was to evaluate the clinical outcomes of short-course radiotherapy (RT) followed by systemic chemotherapy for patients with rectal cancer with mesorectal fascia (MRF) involvement and unresectable distant metastases. Methods: The study included consecutive patients diagnosed as having metastatic mid-to-low rectal cancer treated with short-course RT followed by systemic chemotherapy for conversion radical or palliative surgery between 2014 and 2019 at Gil Medical Center. The patients had primary rectal tumors involving the MRF and unresectable distant metastases. The treatment strategies were determined in a multidisciplinary team discussion. Results: Seven patients (five men and two women) underwent short-course RT (5×5 Gy) and preoperative systemic chemotherapy. The median age was 68 years (range, 46–84 years), and the median distance from the anal verge to the primary tumor was 6.0 cm (range, 2.0–9.0 cm). During the median follow-up period of 29.4 months, three patients underwent conversion radical surgery with R0 resection, two underwent palliative surgery, and two could not undergo surgery. No postoperative major morbidity or mortality occurred. The patients who underwent conversion complete radical surgery showed good long-term survival outcomes, with an overall survival time of 29.4–48.8 months and progression-free survival time of 14.7–41.1 months. Conclusion: Short-course RT followed by systemic chemotherapy could provide patients with unresectable stage IV rectal cancer a chance to undergo to conversion radical surgery with good long-term survival outcomes.
Jeon, Youngbae,Sunesh, Chozhidakath Damodharan,Chitumalla, Ramesh Kumar,Jang, Joonkyung,Choe, Youngson Elsevier 2016 ELECTROCHIMICA ACTA Vol.195 No.-
<P><B>Abstract</B></P> <P>In this paper, we report highly luminescent yellow and orange light-emitting electrochemical cells (LECs) using cationic iridium complexes, i.e., [Ir(ppy)<SUB>2</SUB>(mpbi)]PF<SUB>6</SUB> (Complex 1) and [Ir(bpbt)<SUB>2</SUB>(mpbi)]PF<SUB>6</SUB> (Complex 2), which contain 2-phenylpyridine (ppy) and 2-(4-bromophenyl)benzothiazole (bpbt) as the cyclometalating ligands, respectively, and 2-(4-methyl-2-pyridyl)-1H-benzimidazole (mpbi) as the ancillary ligand. The emissions of Complex 1 and Complex 2 are yellow and yellowish-green in acetonitrile solution. The geometrical, electronic, and optical properties of the two novel Ir complexes were investigated by density functional theory (DFT) and time-dependent DFT using the B3LYP method. LECs incorporating Complexes 1 and 2 emit yellow (553nm) and orange (600nm) electroluminescence, respectively. Upon the meticulous selection of organic ligands, a significant increase in luminescence was achieved for Complex 1 (3636cd/m<SUP>2</SUP>) over that of Complex 2 (2315cd/m<SUP>2</SUP>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly luminescent yellow and orange light-emitting devices were fabricated. </LI> <LI> The emissions of Complex 1 and 2 are yellow and yellowish-green in solution. </LI> <LI> DFT and TDDFT calculations were performed for all complexes. </LI> <LI> A significant increase in luminescence was achieved for Complex 1 (3636cd/m<SUP>2</SUP>). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
효율적인 임무 피해 평가를 위한 자산-임무 의존성 모델 적용 및 최적화된 구현
전영배(Youngbae Jeon),정현숙(Hyunsook Jeong),한인성(In sung Han),윤지원(Jiwon Yoon) 한국정보과학회 2017 정보과학회 컴퓨팅의 실제 논문지 Vol.23 No.10
사이버 임무 피해 정량화는 정해져있는 임무에 따라 움직여 집단의 목표를 이룩하거나 이윤을 창출하는 군(軍)이나 기업들에게 빠질 수 없는 필수적인 작업이다. 조직이 지닌 자산에 대한 피해가 발생하였을 때, 수행 목표에 대한 피해를 최소화하기 위해 남은 자산만으로 달성할 수 있는 임무의 최대 수용력(capacity)을 정량화하고 빠른 시간 안에 새로운 차선책을 마련하여야 한다. 이를 위해서 자산과 임무에 대한 관계를 모델링하여 정형화하면 사이버 공격이 임무에 미친 피해 영향도를 계산할 수 있다. 본 논문에서는 자산과 과업의 관리 업무를 분리하여 효율적인 관리가 가능하도록 자산과 임무 사이의 의존성에 대한 모델을 적용하였고, 적용한 모델을 바탕으로 벡터 단위의 오퍼레이션을 이용하여 계산의 병렬화나 버퍼를 이용해 연산속도를 향상시키는 등 빠른 시간 안에 계산을 완료할 수 있는 최적화된 시스템을 구현하였다. Cyber Mission Impact Assessment is one of the essential tasks which many militaries and industrial major companies should perform to effectively achieve their mission. The unexpected damage to an organization"s assets results in damage to the whole system’s performance of the organizations. In order to minimize the damage, it is necessary to quantify the available capacity of the mission, which can be achieved only with the remaining assets, and to immediately prepare a new second best plan in a moment. We therefore need to estimate the exact cyber attack’s impact to the mission when the unwanted damage occurs by modeling the relationship between the assets and the missions. In this paper, we propose a new model which deals with the dependencies between assets and missions for obtaining the exact impact of a cyber attack. The proposed model distinguishes task management from asset management for an efficient process, and it is implemented to be optimized using a vectorized operation for parallel processing and using a buffer to reduce the computation time.
Se-Beom Jeon,Youngbae Jeon,Kyoung-Won Han,Yong-Soon Chun,Jeong-Heum Baek 대한종양외과학회 2021 Korean Journal of Clinical Oncology Vol.17 No.1
Purpose: This study aimed to investigate the clinical outcomes after totally implantable access port (TIAP) implantation performed by general surgery residents in patients with colorectal cancer. Methods: A total of 291 consecutive patients who underwent TIAP implantations were evaluated. The patients were divided into three groups: second-, third-, and fourth-grade residents. Results: The mean follow-up was 22.1 months (range, 1–87 months). The total times of operation, puncture, and cannulation decreased as the resident grade increased (P<0.001). Early complications significantly decreased with higher resident grades (P=0.039). The non-use of ultrasonography and non-use of C-arm were identified as independent risk factors for complications. Resident grades between second and third (P=0.005) and between second and fourth (P=0.041) were identified as independent risk factors for optimal tip position. Conclusion: TIAP implantation can be safely and effectively performed by residents. Low-grade residents were associated with early complications.