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S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis
Yi, S.,Um, S.,Lee, J.,Yoo, J.,Bang, S.,Park, E.,Lee, M.,Nam, K.,Jeon, Y.,Park, J.,You, J.,Lee, S.J.,Bae, G.U.,Rhie, J.,Kozma, Sara C.,Thomas, G.,Han, J.W. Cell Press 2016 Molecular Cell Vol.62 No.3
S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program required for the commitment of mesenchymal stem cells to the adipocytic lineage. However, in contrast to its role in the cytosol, the functions and targets of nuclear S6K1 are unknown. Here, we show that adipogenic stimuli trigger nuclear translocation of S6K1, leading to H2BS36 phosphorylation and recruitment of EZH2 to H3, which mediates H3K27 trimethylation. This blocks Wnt gene expression, inducing the upregulation of PPARγ and Cebpa and driving increased adipogenesis. Consistent with this finding, white adipose tissue from S6K1-deficient mice exhibits no detectable H2BS36 phosphorylation or H3K27 trimethylation, whereas both responses are highly elevated in obese humans or in mice fed a high-fat diet. These findings define an S6K1-dependent mechanism in early adipogenesis, contributing to the promotion of obesity.
Detection of Genotype associated with Disease Activity and Development of Probe
Jang,S. I.,Yoo,S. K.,Im,M. K.,Kim,J. H.,Kim,W. S.,You,Y. O.,Lee,D. K.,Kim,K. J.,Kim,W. S. 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4
질환성과 관련된 세균의 분포 및 유전자형을 탐색하고자 구강농양 및 골수염의 급성감염 혼자와 진료실 및 실험실의 정상인을 대상으로 시료를 채취하여 포도상구균을 분리 및 동정을 시행하고, 특성을 규명하였으며, plasmid 및 염색유전자를 분리하여 제한효소를 처리후 전기영동을 실시하고 분리된 plasmid로 탐색자를 제작하여 dot blot을 시행하였다. 대부분의 급성환자에서 분리된 포도상구균을 S. lugdunensis와 S. aureus이었으나, 진료실 및 실험실에서는 coagulase 음성 staphylococci가 분리되었다. 급성환자에서 분리된 포도상구균은 ampicillin과 penicillin에 내성을 보였다. 분리된 S. lugdunensis균주중 네 균주는 δ형의 용혈소를 생산하였다. Plasmid를 분리한 결과 S. lugdunensis균주중 세 균주는 약 6.5 kilobases이었으나 S. aureus는 약 4.3 kilobases 정도 크기의 band를 보였다. S. lugdunensis에서 분리된 plasmid로 제작한 탐색자로 dot blot를 시행한 결과 치과 영역에서 분리한 plasmid를 갖는 균주는 양성반응을 보였다. 염색체유전자의 유전자형을 분석한 결과 δ형의 용혈소를 생산한 네 균주의 S. lugdunensis는 유사한 유전자형을 보였다. 이러한 연구결과 질환의 진행에 S. lugdunensis가 중요한 역할을 하는 것으로 생각되고, 치과영역에 존재하는 plasmid는 공통적인 유전자 서열을 갖는 것으로 추정된다.
소결과정에서 Fe_2O_3-CaO-Al_2O_3-SiO_2계로부터 Calcium-Ferrite 생성거동에 미치는 염기도의 영향
黃熙鎭,車榮宰,兪炳敦,韓晶煥,李始衡,許完旭 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.5
The effect of the basicity on the formation behaviour of calcium ferrites was investigated in the sintering process of Fe_2O_3-CaO-Al_2O_3-SiO_2 system. In the system of Fe_2O_3-CaO-Al_2O_3, the mineral structure consists of iron oxide particles and matrix phase, which is likely to be CF(calcium ferrite). When SiO_2 is added into Fe_2O_3-CaO-Al_2O_3 system, the area fraction of CF decreases sharply. When the basicity(CaO/SiO_2) decreases below the unity, CF does not form, and the mineral structure is composed of iron oxide particles and the silicate slag. The iron oxide particles are mainly magnetite in the temperature range higher than 1300℃, while they consist of both magnetite and hematite at the temperatures below 1250℃. When SiO_2 is added into Fe_2O_3-CaO-Al_2O_3 system, the formation of hematite is promoted in the lower temperature range. The increase of SiO_2 content tends to change the composition of CF from hemi-CF to mono-CF. The solubility of solutes such as CaO, Al_2O_3 and SiO_2 in CF increase with the increase of SiO_2 content in the system.
송기욱(K.W. Song),유근봉(K.B. You),현중섭(J.S. Hyun),장성호(S.H. Jang),하정수(J.S. Ha) 대한기계학회 2001 대한기계학회 춘추학술대회 Vol.2001 No.8
Main steam pipe in power plants is subjected to service conditions under which creep processes take place limiting the component's lifetime. To ensure a safe and economic operation it is necessary to get accurate information about the lifetime situation of single components as well as of the whole system. Careful evaluation is combined with FEM analysis, NDT, microstructure evaluation. Especially, 14MoV63 steel is used as material for main steam pipe for 30 years old power plants. In service inspections have shown an increasing number of cracks and and creep cavities beside stress concentration parts. A detailed analysis came to the conclusion that lifetime has been consumed to a high degree, 80%level.