간단한 인증키 동의 프로토콜인 Kim-Kim-Hwang 방법의 안전성 고찰

김윤정;김영신;황준 서울여자대학교 컴퓨터과학연구소 2004 정보기술논문지 Vol.2 No.-

The Diffie-Hellman Key Exchange scheme can produce a common session key between the two communicators, but its problem is that it makes a man-in-the middle attack possible. To solve problems like these, several protocols have been put forward, and the Simple Authenticated Key Agreement (SAKA) Protocol is among them. Seo-Sweeney suggested a SAKA protocol initially and the protocol has weakness that a malicious 3rd party can masquerade a valid user. Tseng suggested another protocol that advances this problem but this protocol can still be attacked when the messages in key verification phase are identical. Ku-Wang suggested a new protocol that advances this problem. Kim-Kim-Hwang also suggested a new SAKA protocol and confirmed that their protocol has same safeness and better performance compared to the other SAKA protocols. In this paper, we reanalyze the safeness of SAKA protocols and find out that Kim-Kim-Hwang protocol has not only better performance but also better safeness. Diffie-Hellman의 키 인증 기법에 대한 제 3자 공격 (man-in-the middle attack)에 강한 간단한 인증키 동의 프로토콜인 SAKA (Simple Authenticated Key Agreement Protocol)가 제안된 바 있다. SAKA는 초기에 Seo-Sweeney에 의해 제안되었으며 이 방법은 침입자가 중간에 메시지를 가로채서 정당한 사용자임을 가장할 수 있는 단점이 있다. Tseng은 이 단점을 개선한 방안을 제안하였는데 이것도 키 확인 메시지 두 개의 값이 같을 경우 공격을 받을 수 있음이 밝혀졌다. Ku-Wang은 Tseng 방법의 문제점을 개선한 알고리즘을 제안하였다 그리고 Kim-Kim-Hwang은 새로운 SAKA 알고리즘을 제안하고 이것이 기존 SAKA 프로토콜들과 안전성은 동일하면서도 성능이 개선된 것임을 밝힌바 있다. 본 논문에서는 안전성 분석의 재고찰을 통하여, Kim-Kim-Hwang의 방법이 기존 SAKA 프로토콜들보다 성능면에서뿐만 아니라, 안전성 면에서도 우수함을 밝힌다.

Chemical fingerprint analysis of fermented Morinda citrifolia L. (Noni) juice by UHPLC Q-TOF/MS combined with chemometric analysis

Kim Yoonjeong,Pyeon Jiye,Lee Jae-Yeon,Kim Eun-Min,La Im-Joung,Lee Ok-Hwan,Kim Keono,Sung Jeehye,Kim Younghwa 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-

Morinda citrifolia L. (Noni) has been widely used in traditional medicine in tropical zones and has become increasingly popular globally owing to its health benefits. Most noni fruits are consumed as juice, which is traditionally produced by the natural fermentation of noni fruits. In this study, the metabolic profiles of noni fruit juice (NJ1) and fermented noni fruit juices (NJ2 and NJ3) was compared. A total of 74, 83, and 91 compounds including anthraquinones, coumarins, flavonoids, phenolic acids, phenolics, terpenoids, and miscellaneous (acids, carbohydrates, vitamins, fatty acids, etc.) were tentatively identified from NJ1, NJ2, and NJ3 in both positive and negative electrospray ionization modes. The phenolic compound composition differed significantly between noni juice and fermented noni juice. The results of the unsupervised principal component analysis and hierarchical clustering analysis showed that the non-fermented juice group clustered with the fermented juice groups. Asperulosidic acid, isoasperulosidic acid, and rutin levels were higher in the NJ1 group than those in the NJ2 group. Deacetylasperulosidic acid and monotropein contents in NJ2 were higher than those in NJ1. Similarly, NJ1 had higher asperulosidic acid and isoasperulosidic acid than those in NJ3. The findings from this study have the potential to enhance the quality of fermented noni juice. Morinda citrifolia L. (Noni) has been widely used in traditional medicine in tropical zones and has become increasingly popular globally owing to its health benefits. Most noni fruits are consumed as juice, which is traditionally produced by the natural fermentation of noni fruits. In this study, the metabolic profiles of noni fruit juice (NJ1) and fermented noni fruit juices (NJ2 and NJ3) was compared. A total of 74, 83, and 91 compounds including anthraquinones, coumarins, flavonoids, phenolic acids, phenolics, terpenoids, and miscellaneous (acids, carbohydrates, vitamins, fatty acids, etc.) were tentatively identified from NJ1, NJ2, and NJ3 in both positive and negative electrospray ionization modes. The phenolic compound composition differed significantly between noni juice and fermented noni juice. The results of the unsupervised principal component analysis and hierarchical clustering analysis showed that the non-fermented juice group clustered with the fermented juice groups. Asperulosidic acid, isoasperulosidic acid, and rutin levels were higher in the NJ1 group than those in the NJ2 group. Deacetylasperulosidic acid and monotropein contents in NJ2 were higher than those in NJ1. Similarly, NJ1 had higher asperulosidic acid and isoasperulosidic acid than those in NJ3. The findings from this study have the potential to enhance the quality of fermented noni juice.

Crystal Structure of SmcR, a Quorum-sensing Master Regulator of <i>Vibrio vulnificus</i> , Provides Insight into Its Regulation of Transcription

Kim, Yoonjeong,Kim, Byoung Sik,Park, Yu Jin,Choi, Won-Chan,Hwang, Jungwon,Kang, Beom Sik,Oh, Tae-Kwang,Choi, Sang Ho,Kim, Myung Hee American Society for Biochemistry and Molecular Bi 2010 The Journal of biological chemistry Vol.285 No.18

<P>Quorum sensing has been implicated as an important global regulatory system controlling the expression of numerous virulence factors in bacterial pathogens. SmcR, a homologue of <I>Vibrio harveyi</I> LuxR, has been proposed as a quorum-sensing master regulator of <I>Vibrio vulnificus</I>, an opportunistic human pathogen. Previous studies demonstrated that SmcR is essential for the survival and pathogenesis of <I>V. vulnificus</I>, indicating that inhibiting SmcR is an attractive approach to combat infections by the bacteria. Here, we determined the crystal structure of SmcR at 2.1 Å resolution. The protein structure reveals a typical TetR superfamily fold consisting of an N-terminal DNA binding domain and a C-terminal dimerization domain. <I>In vivo</I> and <I>in vitro</I> functional analysis of the dimerization domain suggested that dimerization of SmcR is vital for its biological regulatory function. The N-terminal DNA recognition and binding residues were assigned based on the protein structure and the results of <I>in vivo</I> and <I>in vitro</I> mutagenesis experiments. Furthermore, protein-DNA interaction experiments suggested that SmcR may have a sophisticated mechanism that enables the protein to recognize each of its many target operators with different affinities.</P>

CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF)

Kim, Somi,Cho, Chang Yun,Lee, Doohyung,Song, Dae-Geun,Kim, Hye-Jin,Jung, Jae Woo,Kim, Ji Eon,Park, Dasomi,Lee, Haesong,Um, Hyejin,Park, Jinsoo,Choi, Yoonjeong,Kim, Yoomin,Nam, Seo Hee,Lee, Jung Weon Elsevier 2018 Cancer letters Vol.438 No.-

<P><B>Abstract</B></P> <P>CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD133, TM4SF5, CD44, and protein tyrosine phosphatase receptor type F (PTPRF) in a three-dimensional (3D) sphere growth system. We found that CD133 upregulated TM4SF5 and CD44, whereas TM4SF5 and CD44 did not affect CD133 expression. Signaling activity following CD133 phosphorylation caused TM4SF5 expression and sphere growth. TM4SF5 bound to CD133 and promoted c-Src activity for CD133 phosphorylation as a positive feedback loop, leading to CD133-mediated sphere growth that was inhibited by TM4SF5 inhibition or suppression. TM4SF5 also bound PTPRF and promoted paxillin phosphorylation. Decreased sphere growth upon CD133 suppression was recovered by TM4SF5 expression and partially by PTPRF suppression. TM4SF5 inhibition enhanced PTPRF levels and abolished PTPRF suppression-mediated sphere growth. Altogether, CD133-induced TM4SF5 expression and function were important for liver cancer sphere growth and may be a promising target to block metastasis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The role of TM4SF5 and CD133 cross-talk in the CSC properties of HCC is unknown. </LI> <LI> CD133-induced c-Src, Akt, and β-catenin signaling mediates TM4SF5 induction. </LI> <LI> TM4SF5 drives CD133 phosphorylation via a bidirectional positive feedback loop. </LI> <LI> TM4SF5 binds PTPRF to regulate cellular signaling for anchorage-independent growth. </LI> <LI> CD133/TM4SF5/PTPRF and CD44 are potential biomarkers for HCC metastasis. </LI> </UL> </P>

에탄올로 유도된 간세포 손상에 대한 조리방법에 따른 자색고구마의 보호 효과

김윤정(Yoonjeong Kim),김다경(Dagyeong Kim),김나은(Naeun Kim),김영화(Younghwa Kim) 한국식품영양과학회 2023 한국식품영양과학회지 Vol.52 No.12

Present study aimed to investigate the effects of three methods, namely, steaming, roasting, and microwaving, of cooking purple sweet potatoes (Ipomoea batatas L.) on hepatoprotective effects against ethanol-induced oxidative stress in HepG2 cells. Vitamin B1 and B7 contents were altered more after steaming than microwaving. The methanolic extracts of raw and cooked purple sweet potato had no cytotoxic effects on HepG2 cells, and raw and steamed potatoes had the greatest cytoprotective effects against ethanol damage. All samples significantly inhibited the generation of reactive oxygen species against ethanol-induced stress after 60 min compared to ethanol-treated controls. Ethanol treatment increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA). However, pretreatment with raw and/or steamed purple sweet potatoes significantly inhibited ALT, AST, and MDA levels. Moreover, pretreatment with raw or steamed purple sweet potato significantly increased glutathione S-transferase levels compared to ethanol treatment alone. Overall, these results suggest that purple sweet potatoes have potential use as a functional food ingredient to ameliorate ethanol-induced liver damage.

MiRNA expression profile in canine mammary gland tumor

Eun Pyo Kim,Chae Young Kim,Sang Wha Kim,Min Young Heo,Heaji Chung,Yoonjeong Yang,Sungin Lee,Wan Hee Kim,Geon A Kim 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1

Free and bound form bioactive compound profiles in germinated black soybean (Glycine max L.)

Kim, Min Young,Jang, Gwi Yeong,Lee, Yoonjeong,Li, Meishan,Ji, Yeong Mi,Yoon, Nara,Lee, Sang Hoon,Kim, Kyung Mi,Lee, Junsoo,Jeong, Heon Sang Korean Society of Food Science and Technology 2016 Food Science and Biotechnology Vol.25 No.6

This study investigated the transition between the free and bound forms of functional compounds in germinated black soybean. Black soybean was germinated at $25^{\circ}C$over 6 days and then the free and bound forms of functional compounds were extracted. Total free polyphenol, flavonoid, and phenolic acid contents in raw black soybean increased from 1.03 mg GAE/g, 0.29 mg CE/g, and $315.67{\mu}g/g$ to 1.44 mg GAE/g, 0.64 mg CE/g, and $511.01{\mu}g/g$, respectively, by 4 days after germination. Changes to phenolic acid compositions can be divided into four groups, and the germination process can convert compounds to phenolic acid via anabolism and catabolism. The highest total free isoflavone content in germinated black soybean ($3,724.40{\mu}g/g$) was observed at 4 days. Bound polyphenol, flavonoid, phenolic acid, and isoflavone contents decreased as the germination period increased. These results suggest that the germination process increased compound functionality in black soybean.

Robust lightweight fingerprint encryption using random block feedback

Kim, Yoonjeong,Yoon, Jihye,Joo, Jeong-Hyun,Yi, Kang IET 2014 Electronics letters Vol.50 No.4

<P>Fingerprint encryption in embedded environments should satisfy both lightweightedness and secureness. Normally, the encryption scheme divides the 8-bit pixel images into bit planes and then performs full encryption for one bit plane, e.g. least significant bit plane, and simple operations for the remaining bit planes. Thus, the scheme performs better compared with the 8-bit full encryption, while the security is decreased since only one bit plane is fully encrypted. An innovative fingerprint encryption scheme is proposed which supports better security while maintaining the overall performance. The proposed scheme uses a bit plane encryption and a random block feedback. The encryption schemes are implemented and tested with 320 sample fingerprint images. The result shows that the scheme has superior aspects compared with the existing bit plane encryption and even with the naive full encryption.</P>

Structural insight into bioremediation of triphenylmethane dyes by Citrobacter sp. triphenylmethane reductase.

Kim, Myung Hee,Kim, Yoonjeong,Park, Hyo-Jung,Lee, Jong Suk,Kwak, Su-Nam,Jung, Woo-Hyuk,Lee, Seung-Goo,Kim, Dooil,Lee, Young-Choon,Oh, Tae-Kwang American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.46

<P>Triphenylmethane dyes are aromatic xenobiotic compounds that are widely considered to be one of the main culprits of environmental pollution. Triphenylmethane reductase (TMR) from Citrobacter sp. strain KCTC 18061P was initially isolated and biochemically characterized as an enzyme that catalyzes the reduction of triphenylmethane dyes. Information from the primary amino acid sequence suggests that TMR is a dinucleotide-binding motif-containing enzyme; however, no other functional clues can be derived from sequence analysis. We present the crystal structure of TMR in complex with NADP+ at 2.0-angstroms resolution. Despite limited sequence similarity, the enzyme shows remarkable structural similarity to short-chain dehydrogenase/reductase (SDR) family proteins. Functional assignments revealed that TMR has features of both classic and extended SDR family members and does not contain a conserved active site. Thus, it constitutes a novel class of SDR family proteins. On the basis of simulated molecular docking using the substrate malachite green and the TMR/NADP+ crystal structure, together with site-directed mutagenesis, we have elucidated a potential molecular mechanism for triphenylmethane dye reduction.</P>

BMP9 Induces Cord Blood–Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1

Kim, Jihye,Kim, Minhyung,Jeong, Yoonjeong,Lee, Wook-bin,Park, Hyojin,Kwon, Ja-Young,Kim, Young-Myeong,Hwang, Daehee,Kwon, Young-Guen American Heart Association 2015 Arteriosclerosis, thrombosis, and vascular biology Vol.35 No.9

<P><B>Objective—</B></P><P>Modulating endothelial progenitor cells (EPCs) is essential for therapeutic angiogenesis, and thus various clinical trials involving EPCs are ongoing. However, the identification of environmental conditions and development of optimal methods are required to accelerate EPC-driven vasculogenesis.</P><P><B>Approach and Results—</B></P><P>We evaluated gene expression profiles of cord blood–derived EPCs and endothelial cells to identify the key factors in EPC→endothelial cell differentiation and to show that transforming growth factor-β family members contribute to EPC differentiation. The expression levels of activin receptor-like kinase 1 (ALK1) and its high-affinity ligand, bone morphogenetic protein 9 (BMP9) were markedly changed in EPC→endothelial cell differentiation. Interestingly, BMP9 induced EPC→endothelial cell differentiation and EPC incorporation into vessel-like structures by acting on ALK1 expressed on EPCs in vitro. BMP9 also induced neovascularization in mice with hindlimb ischemia by increasing vessel formation and the incorporation of EPCs into vessels. Conversely, neovascularization was impaired when ALK1 signaling was blocked. Furthermore, EPCs exposed to either short- or long-term BMP9 stimulation demonstrated these functions in EPC-mediated neovascularization.</P><P><B>Conclusions—</B></P><P>Collectively, our results indicated that BMP9/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9/ALK1 may improve the efficacy of EPC-based therapies for treating ischemic diseases.</P>