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- 저자 : Yongxiu Yang (검색결과 3 건)
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Optimal generalized case–cohort analysis with accelerated failure time model
Yongxiu Cao,Qinglong Yang,Jichang Yu 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.2
Case–cohort design has been widely advocated in large cohort studies when the disease rate is low. When the event is not rare, it is desirable to consider a generalized case–cohort design where the covariates are observed only for a subcohort randomly selected from the underlying cohort and a subset of additional failures outside the subcohort. In this article, we propose the smoothed weighted Gehan estimating equation for regression parameters in the accelerated failure time model under generalized case–cohort design. Asymptotic properties of the proposed estimators are developed. To demonstrate the effectiveness of the generalized case–cohort sampling, we compare it with simple random sampling in terms of asymptotic relative efficiency. Furthermore, we derive the optimal allocation of the subsamples for the proposed design. The performance of the finite sample properties are evaluated via simulation studies. A real data set is analyzed to illustrate the estimating procedure.
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A Research about Adaptive Subdivision Algorithm Based On Doo-Sabin Mode
Xumin Liu,Yongxiu Xu,Xianpeng Yang,Xiaojun Wang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.2
Subdivision surface method is a series of iterative operation adopts a certain subdivision formula for an initial grid, obtains the smooth limits surface finally, and can dispose any arbitrary complex topology grid. At present most of the subdivision algorithm are 1-4 subdivisions and as the number of subdivision increase, the grid grow so too-rapid in the number of patch that it is difficult for the model after subdivision to deal with other things. We proposed an adaptive Doo-Sabin Mode subdivision algorithm to solve this problem, which take the average vector of the vertex and the angle between the intersecting surfaces of the vertex as a measurement criterion. This criterion is used to divide the surface, and then make local subdivision. In this way, when the times of subdivision are fewer (the demand of smoothness is not too high), the effect of subdivision has little difference, but efficiency of the algorithm can be greatly improved. Compared with the normal Doo-Sabin subdivision model, experimental results showed that adaptive Doo-Sabin subdivision algorithm can largely slow the growth speed of the amount of model data on the premise that guarantee the quality of surface.
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Defeng Guan,Chenyang Li,Xiao Lv,Yongxiu Yang 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.5
Objectives: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the molecular mechanisms by which PAB induces apoptosis in HeLa cells. Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to investigate the effect of PAB treatment in various cervical cancer cell lines. Annexin V/propidium iodide staining combined with flow cytometry and Hoechst 33258 staining were used to assess PAB-induced apoptosis. Additionally, we performed bioinformatics analyses and identified a paired box 2 (PAX2) binding site on the BAX promoter. We then validated the binding using luciferase and chromatin immunoprecipitation assays. Finally, western blotting assays were used to investigate PAB effect on the Wnt signaling and the involved signaling molecules. Results: PAB promotes apoptosis and downregulates PAX2 expression in HeLa cells in a time- and concentration-dependent manner. PAX2 binds to the promoter of BAX and inhibits its expression; therefore, PAX2 inhibition is associated with increased levels of BAX, which induces apoptosis of HeLa cells via the mitochondrial pathway. Additionally, PAB inhibits classical Wnt signaling. Conclusion: PAB effectively inhibits Wnt signaling and PAX2 expression, and increases BAX levels, which induce apoptosis in HeLa cells. Therefore, PAB is a promising natural molecule for the treatment of cervical cancer.
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