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우영균 ( Young Kyun Woo ),장주해 ( Ju Hai Chang ),김용식 ( Yong Sik Kim ),권순용 ( Soon Yong Kwon ),김기원 ( Ki Won Kim ),김양수 ( Yang Soo Kim ) 대한고관절학회 1995 Hip and Pelvis Vol.7 No.1
We took a retrospective assessment about the relationships to steroid therapy with 12 patients of AVN in SLE, comparing with the control cases which were composed of 25 patients of SLE followed up more than 5 years but free from evidence of AVN, who had been treated at Catholic University Medical College from 1986 to 1992. Based on results of above assessment, we carried out comparative analysis of above 2 groups to delineate the statistical significance between AVN and steroid therapy in SLE using Student's t-test, and its each items of statistical analysis were as follows; initial cumulative dosage on 1, 3, 6 months, average monthly dosage, average monthly dosage of pulse therapy and average monthly dosage of maintenance therapy throughout follow up period. In addition, we also reported the author's clinical experience in the orthopaedic management of 12 AVN patients in SLE with a respect of age & sex distribution, interval between diagnosis of SLE and AVN, involvement sites, radiologic stage especially in femoral head, treatment method and complication of treatment. This retrospective study was relatively fragmentary but shows that both initial higher steroid therapy and average dosage per months seem to be related with eventual development of AVN in SLE. In addition, the average monthly dosage of pulse therapy seems to have an influence on development of AVN in SLE also. But, the more distinct cause of AVN and the role of steroid in SLE may be elucidated through the further prospective attempt with an elaborate plan in concert with medical doctors.
슬관절 전방십자인대 신연 손상에 따른 기질 금속 단백 분해 효소(MMP)-2의 발현
우영균(Young Kyun Woo),송석환(Seok Whan Song),권순용(Soon Yong Kwon),이화성(Hwa Sung Lee),김영훈(Young Hoon Kim) 대한정형외과학회 2006 대한정형외과학회지 Vol.41 No.4
목적: 조직 재형성 과정은 손상된 조직의 자연 치유에 필수적이다. 세포외 기질 분해에 관여하는 기질 금속단백 분해효소(matrix metalloproteinase, MMP)가 이 과정에서 중요한 역할을 하는데, 본 연구는 전방십자인대의 손상에 따른 MMP-2의 발현을 알아보고자 하였다. 재료 및 방법: MMP-2의 지속적인 발현 여부를 파악하기 위해 쥐에서 대퇴골-전방십자인대-경골 복합체를 얻어 신연 손상을 가한 후 1주일간 관찰하였다. 그 후 인대 복합체를 세 군으로 나누어, 제1군은 5 N 및 12 N으로 10, 30, 60분 동안, 제2군은 5와 15 N의 힘으로 5, 10, 30, 60 및 120분 동안, 제3군에서는 5, 8, 10, 12 및 15 N 하에 각각 30 및 60분 동안 손상을 주었다. MMP-2의 발현은 0.05% gelatine zymography를 이용하여 검사하였다. 결과: 인대 손상 후 MMP-2의 지속적인 분비를 관찰할 수 있었으며, 발현 강도는 손상 받은 시간이나 가해진 힘의 크기에 비례하여 증가하였다. 인대 조직 자체의 검사에서는 배양액의 결과보다 전구형의 발현 강도는 미약했으나, 활성형은 더욱 뚜렷이 나타났으며, 손상 시간 및 크기에 따라 발현 정도는 역시 증가하였다. 결론: MMP-2는 인대 손상 후에 즉각적으로 발현되었으며, 강도는 손상 시간이나 가해진 힘에 비례하여 증가하였다. MMP-2의 발현이 인대 손상 후 진행되는 조직 재형성기 과정에서 중요한 역할을 할 것으로 생각된다. Purpose : Tissue remodeling is essential for the natural healing of damaged tissue. The matrix metalloproteinases (MMPs) that degrade the extracellular matrix to play a central role in this process. This study was designed to examine the basic relationship between MMP-2 and anterior cruciate ligament (ACL) injury. Materials and Methods : After the femur-ACL-tibia complex was harvested from rats, the continuous release of MMP-2 in the stretch group was evaluated. The complexes were divided into three groups. To stretch the complexes, in group I, 5 and 12 N weights were used for 10, 30, and 60 minutes. In group Ⅱ, 5 and 15 N weights were used for 5, 10, 30, 60, and 120 minutes. And in group Ⅲ, 5, 8, 10, 12, and 15 N weights were used for 30 and 60 minutes. MMP-2 activity was evaluated using 0.05% gelatin zymography. Results : MMP-2 was expressed and the signal intensity was increased according to the stretch duration and magnitude. In the tissue analysis, active MMP-2 was markedly present and the expression was increased in response to the stretch in the supernatant samples. Conclusion : MMP-2 was released immediately after ligament injury and its activity was increased in proportion to the stretch duration and magnitude. It is believed that MMP-2 expression plays an important role in the remodeling process after an ACL injury.
김용식 ( Yong Sik Kim ),권순용 ( Soon Yong Kwon ),김기원 ( Ki Won Kim ),정진화 ( Jin Hwa Chung ),우영균 ( Young Kyun Woo ) 대한고관절학회 1995 Hip and Pelvis Vol.7 No.2
This study was designed to demonstrate the presence of bone particles at the surface of the bone mineral particle impregnated bone cement, to determine the amount of the bone particle content, if they do exist, and to explore underlying relationships between the contact area of the bone particles and the interfacial shear strength before and after decalcification. For this purpose, specimens with a thickness of 2mm were harvested from canine femur after total hip arthroplasty using bone mineral particles. A confocal laser scanning microscope was used to analyze the surface of the specimen. Push-out test with an MTS machine were performed to determine the interficial shear strength. The following results were obtained: (1) The contact area of the bone particIes at the surface of the bone mineral impregnated bone,cement increased in relation to the weight percent content. (2) The interfacial shear strength of the bone mineral impregnated bone cement was less then that of the bone cement during the period from immediatly after surgery to 12 weeks postoperatively. (3) Temporal increase in interfacial shear strength was not observed in both bone cement and bone mineral impregnated bone cement. In conclusion, this study demonstrated a contradicting fact from the published results in which an increase in interficial shear strength was reported with bone mineral impregnated bone cement. Therefore, we would like to remain cautious to about using the mineral impregnated bone cement until its effectivness is demonstrated.
부탄가스 흡입으로 유발된 대퇴 골두 무혈성 괴사증 -2예보고 및 동물실험-
김용식 ( Yong Sik Kim ),강창석 ( Chang Suk Kang ),김기원 ( Ki Won Kim ),이화성 ( Hwa Sung Lee ),김정호 ( Jung Ho Kim ),우영균 ( Young Kyun Woo ) 대한고관절학회 1998 Hip and Pelvis Vol.10 No.1
We firstly report two cases of osteonecrosis of the femoral head associated with butane gas inhalation and investigated its pathogenesis with in vivo experimental study. In both patients, the blood level of cholesterol was in normal range while triglyceride level was increased. The characteristic findings of histopathologic change of the proximal head was severe congestion of intraosseous vessels. For in vivo experimental study, the butane gas was inhalated to fifteen rabbits using a specially designed box. Blood chemistry including triglyceride and lipoprotein electrophoresis was measured and the changes of blood vessel and marrow of the proximal femur was observed with histopathologic study. The levels of triglyceride and total cholesterol were increased after butane gas inhalation. Disruption of basement membrane of veins with thrombosis and thrombus of the small to medium sized arteries were observed in and around femoral head. The severe congestion of intraosseous blood vessels was also observed within the femoral head of rabbits. The current study demonstrated that butane gas inhalation may damage to basement membrane of vein around tbe hip joint and elevate the level of triglyceride. In conclusion, butane gas inhalation should be considered as a new etiology for the development of osteonecrosis of the femoral head.