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Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People
Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2
Background/AimsEvidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian and Western populations. Thus, we aim to investigate this issue among young Japanese people. MethodsThe study subjects comprised of 8923 Japanese university students. BMI was divided into 4 categories (quartiles) on the basis of the study subjects’ distribution (lowest, low, moderate, and high [reference]). The definition of lean, normal, overweight, and obese was BMI < 18.5 kg/m2, 18.5 ≤ BMI < 25 kg/m2 (reference), 25 kg/m2 ≤ BMI < 30 kg/m2, and 30 kg/m2 ≤ BMI, respectively. The definition of FD was based on the Rome III criteria. ResultsThe prevalence of FD was 1.9% in this cohort. The lowest BMI was independently associated with FD after adjustment (adjusted odds ratio [OR], 2.88; 95% confidence interval [CI], 1.46-3.67); P for trend = 0.001). The lowest BMI was independently associated with FD in women but not in men (OR, 2.94; 95% CI, 1.59-5.77; P for trend = 0.001). Leanness was independently associated with FD in total and in women but not in men (total: adjusted OR, 2.01; 95% CI, 1.40-2.86) and women (OR, 2.19; 95% CI, 1.35-3.45). However, interaction analysis showed no significant difference for sex. ConclusionsAmong young Japanese people, BMI may be independently inversely associated with FD. Leanness may be an independent associated factor for FD in the young Japanese women.
Yasunori Yamamoto,Shinya Furukawa,Junichi Watanabe,Aki Kato,Katsunori Kusumoto,Teruki Miyake,Eiji Takeshita,Yoshio Ikeda,Naofumi Yamamoto,Katsuhiko Kohara,Syuichi Saheki,Yuka Saeki,Yoichi Hiasa 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Background/AimsFunctional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior and FD. The purpose of this cross-sectional study is to examine the association between eating behavior and prevalence of FD in a young Japanese cohort. MethodsIn this study, we enrolled 8923 Japanese university students. FD is diagnosed based on the Rome III criteria. Eating habits and frequency of meals were investigated using a self-administered questionnaire. ResultsThe FD subjects had a younger mean age, a lower body mass index, and a lower proportion of men compared to the non-FD subjects. An independent positive association between skipping breakfast and/or lunch and FD was found (adjusted ORs were 1.60 [95% CI, 1.10-2.32] for breakfast and 2.52 [95% CI, 1.04-5.18] for lunch). Skipping dinner, extra meals (snacks) or midnight snacks was not associated with FD. The prevalence of FD in subjects eating 1, 2, and 3 meals per day was 4.8%, 2.2%, and 1.7%, respectively. The frequency of meals was independently inversely associated with prevalence of FD (adjusted ORs were 1 per day: 2.72 [95% CI, 1.19-5.42], and 2 per day: 1.69 [95% CI, 1.16-2.43], P for trend = 0.001). ConclusionsIn the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD.
Yoichi Iizuka,Haku Iizuka,Tokue Mieda,Daisuke Tsunoda,Tsuyoshi Sasaki,Tsuyoshi Tajika,Atsushi Yamamoto,Kenji Takagishi 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6
Study Design: A cross-sectional study. Purpose: To clarify the prevalence of chronic nonspecific low back pain (CNSLBP) and its associated factors among middle-aged and elderly Japanese individuals using data from a musculoskeletal examination conducted in general Japanese populations. Overview of Literature: Most studies evaluating low back pain-associated factors have been conducted in Western countries, but they have not always evaluated CNSLBP. Methods: We obtained data on 213 subjects aged >50 years who responded to a survey regarding age, gender, body mass index, lifestyle-related diseases (diabetes mellitus, hypertension, and hyperlipidemia), glucocorticoid use, smoking and alcohol-drinking habits, labor intensity, and chronic low back pain (CLBP) and underwent screening for lumbar spinal stenosis, evaluation for quality of life (QOL), and evaluation for specific spinal pathology via thoracolumbar spine X-rays. We investigated the prevalence of CNSLBP and association between CNSLBP and measured variables. Results: The prevalence of CNSLBP and chronic specific low back pain (CSLBP) was 15.4% and 9.3%, respectively. Among the subjects with CLBP, 62.2% had CNSLBP. In age-adjusted logistic models, smoking habits (p =0.049, odds ratio [OR]=2.594), low back pain (p <0.001, OR=0.974), lumbar function (p =0.001, OR=0.967), and social function (p =0.023, OR=0.976) in the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were significantly associated with CNSLBP, whereas EQ-5D utility score (p =0.024, OR=0.068), low back pain (p =0.007, OR=0.981), lumbar function (p =0.001, OR=0.963), walking ability (p =0.001, OR=0.968), and social function (p =0.002, OR=0.966) in JOABPEQ were significantly associated with CSLBP. Conclusions: CNSLBP among middle-aged and elderly individuals was associated with smoking habits and decreased QOL; however, CSLBP was considered to be more multilaterally associated decreased QOL.
Takanori Kitagawa,Yoichi Iizuka,Hiroki Kobayashi,Tokue Mieda,Daisuke Tsunoda,Atsushi Yamamoto,Tsuyoshi Tajika,Haku Iizuka,Kenji Takagishi 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6
Study Design: Cross-sectional study. Purpose: The purpose of this study was to evaluate the correlation between pelvic tilt (PT) and the sacro-femoral-pubic (SFP) angle, which is easier to identify than PT, in middle-aged and elderly Asian subjects from the general population. Overview of Literature: Measuring PT is important in the diagnosis and treatment of adult spinal deformity. However, identifying femoral heads, which are necessary to determine PT, using sagittal radiographs is often difficult. Methods: Standing coronal and sagittal pelvic radiographs of individuals aged more than 50 years were taken during a local medical examination. The subjects were divided into female, male, and total groups at the time of evaluation. Linear regression analysis was performed to investigate the relationship between PT and the SFP angle, which were obtained from the X-rays. Results: The present study included 291 subjects. There were no statistically significant differences between the left and right SFP angles, and there was gender difference regarding the SFP angle. However, a gender difference was observed regarding PT. The correlation between PT and the SFP angle was substantiated in each group. Pearson’s correlation coefficients between PT and the SFP angle in the total, female, and male groups were 0.696, 0.853, and 0.619, respectively. In the linear regression analysis, PT was calculated as follows: PT=60.1−0.77×(SFP angle) in the total group, PT=62.8−0.80×(SFP angle) in the female group, and PT=51.5−0.64×(SFP angle) in the male group. Conclusions: A significant correlation between PT and the SFP angle was observed in middle-aged and elderly Asian subjects from the general population.
( Rintaro Moroi ),( Katsuya Endo ),( Katsutoshi Yamamoto ),( Takeo Naito ),( Motoyuki Onodera ),( Masatake Kuroha ),( Yoshitake Kanazawa ),( Tomoya Kimura ),( Yoichi Kakuta ),( Atsushi Masamune ),( Yo 대한장연구학회 2019 Intestinal Research Vol.17 No.1
Background/Aims: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn’s disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments. Methods: This was a retrospective, observational, single-center cohort study. Japanese CD patients treated with either infliximab or adalimumab as a first-line therapy were analyzed. The cumulative retention rates of the biologics, relapse-free survival, and surgery-free survival were analyzed using Kaplan-Meier methods. The clinical factors associated with the long-term outcomes were estimated by both the log-rank test and Cox proportional hazard model. Results: The cumulative retention rate was significantly higher in the group with a concomitant elemental diet of ≥900 kcal/day, baseline C-reactive protein (CRP) levels <2.6 mg/dL, and baseline serum albumin levels ≥3.5 g/dL, respectively. The baseline serum albumin levels were also associated with both relapse-free and surgery-free survival. The lack of concomitant use of an elemental diet ≥900 kcal/day was identified as the only independent risk factor for the withdrawal of the biologics. Conclusions: Baseline CRP levels and serum albumin levels could affect the long-term outcomes in CD patients. Concomitant elemental diet of ≥900 kcal/day could have a positive influence on clinical treatment course. (Intest Res 2019;17:94-106)
Acute Median Arcuate Ligament Syndrome after Pancreaticoduodenectomy
( Masaya Kotsuka ),( Sohei Satoi ),( Hiroaki Yanagimoto ),( Tomohisa Yamamoto ),( Hisashi Kosaka ),( Satoshi Hirookaori ),( So Yamaki ),( Yoichi Matsui ),( Masanori Kon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Here we report a case of median arcuate ligament syndrome (MALS) which suddenly developed soon after pancreaticoduodenectomy. Methods: 40-year-old male underwent PD by a diagnosis of pancreatic cancer. Results: Intraoperative exploration showed normal anatomy of the celiac trunk, mesenteric vessels, and related branches. Clamp testing of the GDA showed normal hepatic artery pulsation. Before closing the abdomen, we noted that pulsation of the common hepatic artery became weak, but blood regurgitation was of adequate strength after reopening the cut stump of the right gastric artery. On postoperative day 1, within 12 hours of PD, the liver enzymes, INR, WBC, and CRP were abnormal and rapidly worsened over the next 12 hours. Although the preoperative CT had shown normal CA anatomy and no evidence of MALS, a postoperative scan that included a lateral projection of the CA showed an acute extrinsic stenosis caused by newly developed compression caused by the median arcuate ligament. Widespread liver ischemia was also apparent. The patient underwent urgent reoperation for acute onset MALS causing severe hepatic cytolysis. After division of the median arcuate ligament, the patient’s liver enzymes, INR, and WBC gradually normalized. Eleven days after reoperation, CT showed regular flow into the celiac trunk; the area of liver ischemia was reduced. He was eventually discharged 43 days after the original PD. MALS can have an acute postoperative onset after PD even if all preoperative and intraoperative evaluations are normal particularly in young patients. We hypothesize that a very tight median arcuate ligament presented in this young patient in addition to lymph node clearance around the celiac trunk might induce the stenosis. Conclusions: Patients who acutely deteriorate despite medical treatment should undergo surgical exploration to rule out other conditions and division of the median arcuate ligament if MALS is indeed present.