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Low Power and High Speed Network on Chip Architecture for BP Neural Network
Yiping Dong,Yinghe Li,Yang Wang,Takahiro Watanabe 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
Back Propagation Artificial Neural Network (BP-ANN), one of widely used neural networks, has been used in a lot of areas. Hardware architecture of BP-ANN was proposed by using an NoC (Network on Chip) and implemented on FPGA. In this paper, new NoC architecture which has a torus topology and IXY (Intelligent XY) routing algorithm is developed for BP-ANN to make it low power and high performance. This system is implemented by FPGA to estimate system performance and power consumption. NIRGAM NoC simulator is also used to evaluate latency and throughput of this system. Experimental results show that our proposed architecture can increase Connection Per Second (CPS) about 2 times than existing digital hardware ANN; it can reduce communication load which total packet size can reduce about 3.2 times compared with traditional packet transmit method of BP-ANN. It can reduce latency by 23.7% and dynamic power consumption by 7.2% compare with the former NoC architecture BP-ANN. It is reconfigurable and expandable to meet various ANN applications. Furthermore other type ANNs can also be implemented in the system by adjusting a routing algorithm of NoCs.
Curcumin Induces Apoptosis and Inhibits Growth of Human Burkitt’s Lymphoma in Xenograft Mouse Model
Zai-xin Li,Ke-qing Ouyang,Xv Jiang,Dong Wang,Yinghe Hu 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.3
Curcumin, a natural compound extracted from rhizomes of curcuma Curcuma species, has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative properties. However, the mechanism of action of the compound remains poorly understood. In this report, we have analyzed the effects of curcumin on the cell proliferation of Burkitt’s lymphoma Raji cells. The results demonstrated that curcumin could effectively inhibit the growth of Raji cells in a dose- and time-dependent manner. Further studies indicated that curcumin treatment resulted in apoptosis of cells. Biochemical analysis showed that the expression of Bax, Bid and cytochrome C were up-regulated, while the expression of oncogene c-Myc was down regulated after curcumin treatment. Furthermore, poly (ADP-ribose) polymerase (PARP) cleavage was induced by the compound. Interestingly, the anti-apoptotic Bcl-2 expression was not significantly changed in Raji cells after curcumin treatment. These results suggested that the mechanism of action of curcumin was to induce mitochondrial damage and therefore led to Raji cell apoptosis. We further investigated the in vivo effects of curcumin on the growth of xenograft tumors in nude mice. The results showed that curcumin could effectively inhibit tumor growth in the xenograft mouse model. The overall results showed that curcumin could suppress the growth of Burkitt’s lymphoma cells in both in vitro and in vivo systems.