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- 저자 : Yerra, Rajeshwar (검색결과 4 건)
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Spermidine alleviates oxidative stress in silk glands of Bombyx mori
Aparna Yerra,Surekha Challa,Satyavathi V. Valluri,Anitha Mamillapalli 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4
Silk gland is a specialized organ for the synthesis of silk. Spermidine is a natural polyamine present in all living cells. It gained attention recently due to its role in longevity and growth promotion. Our earlier study reported enhancement in silk production after spermidine treatment during the 5th instar larval stage of Bombyx mori hybrid strain CSR2 × CSR4. Oxidative stress increases during the degeneration of silk glands in spinning stage. Spermidine plays an important role in relieving oxidative stress. Results showed that exogenous administration of natural polyamine, spermidine, significantly increased the metabolic activity and reduced the oxidative stress of the silk gland in the pre-pupal stage. Expression analysis also confirmed increase in metabolic activity of silk glands after spermidine treatment by showing enhancement inMYC gene expression. Finally, our results demonstrate that supplementation of spermidine enhanced cell viability and decreased oxidative stress of the silk glands. Thiswork also opens up the idea of feeding antioxidants to silkworms which would be beneficial to the sericulture farmers.
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A Coupled Multiscale Model of Texture Evolution and Plastic Anisotropy
J. Gawad,A. Van Bael,S. K. Yerra,G. Samaey,P. Van Houtte,D. Roose 한국소성가공학회 2010 기타자료 Vol.2010 No.6
In this paper we present a multiscale model of a plastic deformation process in which the anisotropy of plastic properties is related to the evolution of the crystallographic texture. The model spans several length scales from the macroscopic deformation of the workpiece to the microscale interactions between individual grains in a polycrystalline material. The macroscopic behaviour of the material is described by means of a Finite Element (FE) model. Plastic anisotropy is taken into account in a constitutive law, based on the concept of a plastic potential in strain rate space. The coefficients of a sixth-order Facet equation are determined using the Taylor theory, provided that the current crystallographic texture at a given FE integration point is known. Texture evolution in the FE integration points is predicted by an ALAMEL micromechanical model. Mutual interactions between coarse and fine scale are inherent in the physics of the deformation process. These dependencies are taken into account by full bidirectional coupling in the model. Therefore, the plastic deformation influences the crystallographic texture and the evolution of the texture induces anisotropy of the macroscopic deformation. The presented approach enables an adaptive texture and yield surface update scheme with respect to the local plastic deformation in the FE integration points. Additionally, the computational cost related to the updates of the constitutive law is reduced by application of parallel computing techniques. Suitability of on-demand computing for this computational problem is discussed. The parallelization strategy addresses both distributed memory and shared memory architectures. The cup drawing process has been simulated using the multiscale model outlined above. The discussion of results includes the analysis of the planar anisotropy in the cup and the influence of complex deformation path on texture development. Evolution of texture at selected material points is assessed as well.
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Novel Mononuclear Ruthenium(II) Compounds in Cancer Therapy
Anchuri, Shyam Sunder,Thota, Sreekanth,Yerra, Rajeshwar,Devarakonda, Krishna Prasad,Dhulipala, Satyavati Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
The present study was conducted to evaluate in vivo anticancer activity of two novel mononuclear ruthenium(II) compounds, namely Ru(1,10-phenanthroline)$_2$(2-nitro phenyl thiosemicarbazone)$Cl_2$(Compound $R_1$) and Ru (1,10-phenanthroline)$_2$(2-hydroxy phenyl thiosemicarbazone)$Cl_2$(Compound $R_2$) against Ehrlich ascites carcinoma (EAC) mice and in vitro cytotoxic activity against IEC-6 (small intestine) cell lines and Artemia salina nauplii using MTT [(3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide)] and BLT [brine shrimp lethality] assays respectively. The tested ruthenium compounds at the doses 2 and 4 mg/kg body weight showed promising biological activity especially in decreasing the tumor volume, viable ascites cell counts and body weights. These compounds prolonged the life span (% ILS), mean survival time (MST) of mice bearing-EAC tumor. The results for in vitro cytotoxicity against IEC-6 cells showed the ruthenium compound $R_2$ to have significant cytotoxic activity with a $IC_{50}$ value of $20.0{\mu}g/mL$ than $R_1$ ($IC_{50}=78.8{\mu}g/mL$) in the MTT assay and the $LC_{50}$ values of $R_1$ and $R_2$ compounds were found to be 38.3 and $43.8{\mu}g/mL$ respectively in the BLT assay. The biochemical and histopathological results revealed that there was no significant hepatotoxicity and nephrotoxicity associated with the ruthenium administration to mice.
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B. Murali Krishna,V. Guru Prathap Reddy,T. Tadepalli,P. Rathish Kumar,Yerra Lahir 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.6
Understanding the realistic behavior of concrete up to failure under different loading conditions within the framework of damage mechanics and plasticity would lead to an enhanced design of concrete structures. In the present investigation, QR (Quick Response) code based random speckle pattern is used as a non-contact sensor, which is an innovative approach in the field of digital image correlation (DIC). A four-point bending test was performed on RC beams of size 1800 mm x 150 mm x 200 mm. Image processing was done using an open source Ncorr algorithm for the results obtained using random speckle pattern and QR code based random speckle pattern. Load-deflection curves of RC beams were plotted for the results obtained using both contact and non-contact (DIC) sensors, and further, Moment (M)-Curvature (κ) relationship of RC beams was developed. The loading curves obtained were used as input data for material model parameters in finite element analysis. In finite element method (FEM) based software, concrete damage plasticity (CDP) constitutive model is used to predict the realistic nonlinear quasi-static flexural behavior of RC beams for monotonic loading condition. The results obtained using QR code based DIC are observed to be on par with conventional results and FEM results.
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