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- 저자 : Yasmeen Junejo (검색결과 2 건)
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Efficient degradation of organic dyes by heterogeneous cefdinir derived silver nanocatalyst
Muhammad Safdar,Yasmeen Junejo,Aamna Balouch 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.31 No.-
Cefdinir derived silver nanocatalyst (Cef-Ag (0) NPs) was successfully synthesized in aqueous solution byefficient one-pot method and effectively employed for the ultrafast catalytic degradation of Rose Bengaland Eosin Gelblich dyes. The improvement was achieved in percent degradation of toxic dyes by varyingand optimizing reaction time, and amount of catalyst reducing agent concentration. The catalytic studyrevealed that complete reduction 99.9% of dye was accomplished in short period of reaction time (60 s)by efficient cefdinir derived silver nanoparticles. The calculated K (rate constant) value for RB and EGcatalytic degradation was achieved 7 10 2 and 10 10 2 s 1, respectively by plotting lnC vs time (s)and result show that reaction is following first order kinetics.
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Hashmat Zoya,Channa Iffat Saeed,Safdar Muhammad,Ozaslan Mehmet,Saeed Muhammad,Siddique Faisal,Junejo Yasmeen 한국독성학회 2022 Toxicological Research Vol.38 No.3
Drug induced liver injury (DILI) is a global issue and acetaminophen (APAP) is considered as the main cause of this. Due to increasing incidents of DILI, current study attempted to investigate an alternative but better role of terazosin (alpha-adrenergic blocker) in APAP-induced acute liver injury in an animal model using New Zealand rabbits. APAP (1 g/kg of body weight) was given to New Zealand rabbits either with or without terazosin (0.5 mg/kg) and serum was collected after 4 h. Serum alanine transaminase (ALT), alkaline phosphatase (ALP) and ferritin level were determined to analyze the liver functioning of treated rabbits. Furthermore, total cholesterol (TC), total lipids (TL), high-density lipoproteins (HDL), low-density lipoprotein (LDL) and triglycerides (TG) levels were estimated to find any change in lipid profile of the treated animals. Moreover, the urea and creatinine levels assayed the actual renal functionality. To identify any modification in gene expression, qPCR of cytochrome P2E1 (CYP2E1) was performed. Terazosin in combination with APAP enhanced liver functioning by reducing the levels of liver injury markers viz. ALP and ALT, while lipid profile was also lowered by down regulation of TC, TL, LDL and TG with enhanced HDL levels. It caused significant down regulation of expression level of CYP2E1. It is concluded that terazosin has better effects induced on the recovery of normal liver functioning, by improving the liver profile, lipid profile and renal functioning both at tissue and molecular levels.
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