Image Restoration Based on Quadtree Data Structures

Yanhua Ma 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.8

This paper investigates the problem of image restoration when the image is corrupted by Pepper-and-salt noise and proposes a new restoration algorithm based on quadtree data structures. The crucial parts of the algorithm are picking noise and fuzzy estimation, so that unlike some other usual denoising methods, it avoids blurring and averaging edges and non-noise pixels. This paper describes, analyzes and compares several methods and results of removing noise from image. Experimental results indicate that the new algorithm proposed by this paper is superior.

SHAPE OPTIMIZATION OF THIN-WALLED CROSS SECTION FOR AUTOMOBILE BODY CONSIDERING STAMPING COST, MANUFACTURABILITY AND STRUCTURAL STIFFNESS

Yanhua Ma,Rui Chen,Jiantao Bai,Wenjie Zuo 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.2

At the conceptual design stage, the cross-sectional shapes of thin-walled beams (TWBs) need to be optimized to improve the performance of automobile structure. Therefore, this paper innovatively proposes a cross-sectional shape optimization method to acquire a low cost, high stiffness, manufacturable and lightweight TWB. Meanwhile, the stamping cost of thin-walled beams is analytically derived. The cross-sectional area is taken as the objective function to establish an optimization formulation with multiple constraints such as cross-sectional stiffness, manufacturability and cost of TWBs. The single-objective genetic algorithm based on non-dominant principle is introduced to solve the problem. The effectiveness of the proposed method is verified by an example of double cell cross-sectional shape.

ANALYTICAL SENSITIVITY ANALYSIS METHOD OF CROSSSECTIONAL SHAPE FOR THIN-WALLED AUTOMOBILE FRAME CONSIDERING GLOBAL PERFORMANCES

Yanhua Ma,Xinchen Wang,Wenjie Zuo 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.5

At the conceptual design stage, thin-walled beams (TWBs) with the complex cross-sectional shapes are extensively used to compose the automobile frame. Thus, the performances of automobile frame are determined by crosssectional shapes of TWBs. Currently, the modifications of complex cross-sectional shapes depend on the experience of engineers, which often causes the design risk. Meanwhile, to our knowledge, the previous studies mainly focused on the regular cross sections and paid little attention for the complex cross-sectional shape for the automobile frame. Therefore, this paper proposes an analytical sensitivity analysis method to modify the complex cross-sectional shapes. This method regards the coordinates of points and the thicknesses of sheets as design variables to describe the cross-sectional shapes. The bending stiffness, torsional stiffness and frequency are used to evaluate the performances of automobile frame. Finally, an example of the RAV4 automobile frame verifies that the analytical sensitivity analysis method can effectively guide the modification of the cross-sectional shape and achieve the lightweight automobile frame.

Comparison of Survival Rates between Chinese and Thai Patients with Breast Cancer

Che, Yanhua,You, Jing,Zhou, Shaojiang,Li, Li,Wang, Yeying,Yang, Yue,Guo, Xuejun,Ma, Sijia,Sriplung, Hutcha Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

The burden and severity of a cancer can be reflected by patterns of survival. Breast cancer prognosis between two countries with a different socioeconomic status and cultural beliefs may exhibit wide variation. This study aimed to describe survival in patients with breast cancer in China and Thailand in relation to demographic and clinical prognostic information. Materials and Methods: We compared the survival of 1,504 Chinese women in Yunnan province and 929 Thai women in Songkhla with breast cancer from 2006 to 2010. Descriptive prognostic comparisons between the Chinese and Thai women were performed by relative survival analysis. A Cox regression model was used to calculate the hazard ratios of death, taking into account the age, disease stage, period of diagnosis and country. Results: The overall 5-year survival proportion for patients diagnosed with breast cancer for Yunnan province (0.72) appeared slightly better than Songkhla (0.70) without statistical significance. Thai women diagnosed with distant and regional breast cancer had poorer survival than Chinese women. Disease stage was the most important determinant of survival from the results of Cox regression model. Conclusions: Breast cancer patients in Kunming had slightly greater five-year survival rate than patients in Songkhla. Both Chinese and Thai women need improvement in prognosis, which could conceivably be attained through increased public education and awareness regarding early detection and compliance to treatment protocols.

Chloride Diffusivity of High-Performance Concrete due to Early-Age Shrinkage Cracking

Li-Na Ma,Yanhua Zhao,Jinxin Gong 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.12

Due to the addition of mineral admixtures, early-age shrinkage cracking is a common feature in high-performance concrete (HPC). Chloride diffusivity of HPC due to early-age shrinkage cracking was investigated through rapid chloride migration (RCM) method. Restrained/unrestrained slabs made of HPC containing fly ash (FA) and ground granulated blast-furnace slag (GGBS) were left outdoors for early-age shrinkage cracking, and then cylindrical samples were drilled from slabs for RCM test to quantify the chloride diffusion coefficient, wherein a crack influence factor was introduced to account for the contribution of cracking in the chloride diffusivity progress. Test results from unrestrained HPC reveal that the addition of mineral admixtures could densify the pore structure of HPC thus improved the chloride diffusion coefficient, though FA had a delayed effect. The RCM tests from restrained HPC indicate that the crack indeed had an effect on the chloride ion transportation, but pore structure still dominated the chloride ingress. For a fixed cement replacement, the more the GGBS in the mix, the higher the contribution of cracking to chloride ion penetration.

Study of the relationship between variants near CCNL1/LEKR1 and in ADCY5 with low birth weight in a Chinese population

Xuejin Fan,Qi Peng,Yanhua Chen,Zeke Ma,Xiaoguang He,Biying Deng,Hui Huang,Juan Zeng,Chuyun Cheng,Shaoji Liu,Xiaomei Lu 한국유전학회 2015 Genes & Genomics Vol.37 No.12

The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.

BMB : Reports ; An inhibitory role of NEK6 in TGFβ/Smad signaling pathway

( Jie Zuo ),( Haijie Ma ),( Hao Cai ),( Yanhua Wu ),( Wei Jiang ),( Long Yu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.8

The NEK6 (NIMA-related kinases 6) is reported to play po-tential roles in tumorigenesis. Although it is suggested to function in several cellular pathways, the underlying mechanism in tumorigenesis is still largely unknown. In the present study, we discovered interaction of NEK6 with Smad4, a key member of transforming growth factor beta (TGFβ) pathway. Over-expression of NEK6 in hepatocellular carcinoma (HCC) cell lines suppresses TGFβ- mediated transcription activity in a kinase activity-dependent manner. In addition, NEK6 suppresses the cell growth arrest induced by TGFβ. Mechanically, NEK6 blocks nuclear translocation of Smad4, which is essential for TGF β function. Moreover, we identified that NEK6 could be regulated by TGFβ and hypoxia. Our study sheds new light on the roles of NEK6 in canonical TGFβ/Smad pathway and tum-origenesis. [BMB Reports 2015; 48(8): 473-478]

Efficacy and Safety of Pulse Magnetic Therapy System in Insomnia Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Liao Jiwu,Wang Sisi,Zhou Borong,Liang Wei,Ma Ping,Lin Min,Lin Weisen,Li Congrui,Zhang Xiaotao,Li Hongyao,Cui Yin,Hu Jiajia,Qin Yuanyi,Deng Yanhua,Fu Aibing,Zhu Tianhua,Zhang Shanlian,Qu Yunhong,Xing L 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.6

Objective This study’s objective is to assess the efficacy and safety of Pulsed Magnetic Therapy System (PMTS) in improving insomnia disorder.Methods Participants with insomnia disorder were randomly assigned to receive either PMTS or sham treatment for four weeks (n= 153; PMTS: 76, sham: 77). Primary outcomes are the Insomnia Severity Index (ISI) scores at week 0 (baseline), 1, 2, 3, 4 (treatment), and 5 (follow-up). Secondary outcomes are the Pittsburgh Sleep Quality Index at baseline and week 4, and weekly sleep diary-derived values for sleep latency, sleep efficiency, real sleep time, waking after sleep onset, and sleep duration.Results The ISI scores of the PMTS group and the sham group were 7.13±0.50, 11.07±0.51 at week 4, respectively. There was a significant group×time interaction for ISI (F3.214, 485.271=24.25, p<0.001, ηp 2=0.138). Only the PMTS group experienced continuous improvement throughout the study; in contrast, the sham group only experienced a modest improvement after the first week of therapy. At the end of the treatment and one week after it, the response of the PMTS group were 69.7% (95% confidence interval [CI]: 58.6%–79.0%), 75.0% (95% CI: 64.1%–83.4%), respectively, which were higher than the response of the sham group (p<0.001). For each of the secondary outcomes, similar group×time interactions were discovered. The effects of the treatment persisted for at least a week.Conclusion PMTS is safe and effective in improving insomnia disorders.