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- 저자 : Yangkyo P. Salch (검색결과 1 건)
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Paul J. Park,김아름,Yangkyo P. Salch,송택선,신성재,한승정,조상래 한국미생물학회 2014 The journal of microbiology Vol.52 No.10
Mycobacterium tuberculosis-specific antigens would be ofgreat value in developing immunodiagnostic tests for tuberculosis(TB), but regional differences in molecular types ofthe organism may result in antigenic variation, which in turnaffects the outcome of the tests. For example, the Beijingstrains of M. tuberculosis are prevalent in East Asia, and inparticular, the K strain and related strains of the Beijingfamily, are most frequently isolated during school outbreaksof TB in South Korea. From comparison of genome sequencesbetween M. tuberculosis K strain and the H37Rv strain, anon-Beijing type, we identified a K strain-specific gene, InsB,which has substantial homology with the ESAT-6-like proteins. This study was, therefore, initiated to characterize theInsB protein for its immunogenicity in mice and to confirmits expression in TB patients by detecting antibodies to theprotein. The InsB gene was cloned from M. tuberculosis Kstrain and expressed in Escherichia coli. The recombinantInsB protein was used for immunization of mice. All miceshowed strong antibody responses to the InsB protein, andsplenocytes stimulated with InsB showed strong IFN-γ andIL-17 responses and a weak IL-2 response, all of which havebeen implicated in disease expression and used for the immunodiagnosisof TB. Serum samples from TB patients alsoshowed significant antibody responses to the InsB protein ascompared to healthy control samples. These results indicatethat the InsB protein is an M. tuberculosis K-strain-specificantigen that could further improve the current immunodiagnosticmethods, especially for the South Korean population.
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