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Diagnostic Value of Ascitic Tumor Markers for Gastric Cancer-associated Malignant Ascites
Yang Yaewon,Kim Hong Jun,Go Se-il,배우균,Song Eun-Kee,Byeon Seonggyu,Kim Hee Kyung,Jeong Yusook,권지현,Lee Ki Hyeong,채희복,손승명,Kim Dae Hoon,윤효영,Han Hye Sook 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.1
Background/Aims: Peritoneal carcinomatosis with malignant ascites is common in patients with advanced gastric cancer (GC). The detection of tumor cells is the gold standard for the diagnosis of malignant ascites; however, it often requires complementary tests because of its low sensitivity. Herein, we measured the levels of tumor markers in the malignant ascites of GC patients (GC-ascites) and benign ascites of liver cirrhosis patients (LC-ascites) to elucidate the diagnostic value of tumor markers in GC-ascites. Materials and Methods: The levels of CEA, cancer antigen 72-4 (CA 72-4), CA 19-9, and CA 125 were measured in 138 GC-ascites and 64 LC-ascites samples obtained from the National Biobank of Korea. We performed receiver operating characteristic curve analysis to determine the optimal cutoff value for each tumor marker. Results: CEA, CA 72-4, and CA 19-9 levels were significantly higher in GC-ascites than in LC-ascites. There was no difference in tumor marker levels between GC-ascites samples irrespective of cytology. CEA, CA 72-4, and CA 19-9 had sensitivities of 85.5%, 79.0%, and 61.6%, respectively, and specificities of 96.8%, 100.0%, and 89.1%, respectively, for distinguishing GC-ascites samples from LC-ascites samples. The diagnostic accuracy was improved by combining two or more tumor markers. The combination of CEA and CA 72-4 showed the highest sensitivity (86.2%) and specificity (100%). Conclusions: Measurement of tumor markers, such as CEA, CA 72-4, and CA 19-9, in ascites samples could help diagnose GC-ascites, and combining two or more tumor markers could further increase the diagnostic yield, even in cytology-negative patients.
Yang, Sena,Lim, Heeseon,Park, Eun Hee,Kim, Yaewon,Min, Young Hwan,Lee, Hee-Seung,Kim, Sehun,Lee, Hangil American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.49
<P>The discrepancy of geometric configuration between phenylalanine and tyrosine adsorbed on Ge(100) surfaces was investigated using scanning tunneling microscopy (STM) in conjunction with density functional theory (DFT) calculations and core-level photoemission spectroscopy (CLPES). The study focused on the role of nucleophilic group (hydroxyl group) on phenyl ring of tyrosine, and we elucidated the difference of the adsorption geometry between phenylalanine and tyrosine on Ge(100) surfaces. We first confirmed that the “O–H dissociated–N dative bonded structure” was the most favorable structure in both molecules at low coverage by results of CLPES and DFT calculations. Geometric differences for the adsorption configurations between phenylalanine and tyrosine were observed: the phenyl ring of phenylalanine was aligned axially with respect to the Ge(100) surface, whereas that of tyrosine was tilted, as determined by DFT calculations. In sequence, we found out the results of STM images to confirm DFT results. We determined the different geometric configurations are attributed to the nucleophilic hydroxyl group of tyrosine, which creates an uneven charge distribution.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-49/jp3086039/production/images/medium/jp-2012-086039_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp3086039'>ACS Electronic Supporting Info</A></P>
Confirmation of the coexistence of two tautomers of 2-mercaptothiazoline on the Ge(100) surface
Park, Youngchan,Yang, Sena,Lee, Myungjin,Lim, Heeseon,Kim, Yaewon,Kim, Sehun,Lee, Hangil The Royal Society of Chemistry 2013 Physical chemistry chemical physics Vol.15 No.39
<P>We confirmed the coverage dependent variation of tautomers of 2-mercaptothiazoline (the thiolate and thione forms) adsorbed on the Ge(100) surface under UHV conditions by using HRXPS measurements in conjunction with the DFT calculation method, which was studied before only in aqueous systems. The C 1s, S 2p, and N 1s core-level spectra obtained using HRXPS revealed the simultaneous presence of two distinct adsorption structures in different proportions at both low (0.15 ML) and high (0.65 ML) coverages. Moreover, we modelled the adsorption structures and geometric configurations of the bond states of 2-mercaptothiazoline on the Ge(100) surface by using the DFT calculation method, and found that the S dative bonded structure is the most stable adsorption structure for the thione form of 2-mercaptothiazoline and that the S–H dissociated-N dative bonded structure is the most stable adsorption structure for the thiolate form.</P> <P>Graphic Abstract</P><P>We confirmed the coverage dependent variation of tautomers of 2-mercaptothiazoline (the thiolate and thione forms) adsorbed on the Ge(100) surface under UHV conditions by using HRXPS measurements in conjunction with the DFT calculation method, which was studied before only in aqueous systems. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp52760c'> </P>
Chang, Hyun,Yang, Yaewon,Lee, Jong-Seok,Jheon, Sang-hoon,Kim, Yu Jung,Chung, Jin-Haeng Elsevier 2019 Clinical lung cancer Vol.20 No.1
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>The aim of the present study was to examine the prognostic role of amplification and increased expression of the epidermal growth factor receptor (<I>EGFR</I>) gene in surgically resected non-adenocarcinoma of non-small cell lung cancer (NA-NSCLC).</P> <P><B>Materials and Methods</B></P> <P>The present retrospective study included 114 consecutive NA-NSCLC patients with available tumor tissue and survival data. <I>EGFR</I> gene copy number and protein expression were evaluated using fluorescent in situ hybridization (FISH) and immunohistochemistry in tissue microarray sections, respectively.</P> <P><B>Results</B></P> <P>Among 114 patients, 99 (86.8%) had squamous cell carcinoma histologic features. <I>EGFR</I> gene amplification and high polysomy (<I>EGFR</I> FISH<SUP>+</SUP>) were observed in 7.9% and 31.6% of cases, respectively. Patients with <I>EGFR</I> FISH<SUP>+</SUP> had significantly shorter overall survival (<I>P</I> = .011). A multivariate model confirmed that patients with <I>EGFR</I> FISH<SUP>+</SUP> had a significantly greater risk of death than <I>EGFR</I> FISH<SUP>−</SUP> patients after adjusting for pathologic stage, presence of pleural invasion, venous invasion, and surgical margins (hazard ratio, 1.36; 95% CI, 1.040 to 1.782; <I>P</I> = .025). EGFR protein expression by immunohistochemistry was not associated with overall survival in the same group. Neither <I>EGFR</I> gene amplification nor EGFR immunohistochemistry expression was associated with relapse-free survival.</P> <P><B>Conclusion</B></P> <P>An increased <I>EGFR</I> gene copy number in surgically resected NA-NSCLC was associated with worse survival.</P>
Sequential spinal and intracranial dural metastases in gastric adenocarcinoma: A case report
Kim, Hongsik,Yi, Kyung Sik,Kim, Won-Dong,Son, Seung-Myoung,Yang, Yaewon,Kwon, Jihyun,Han, Hye Sook Baishideng Publishing Group Inc 2018 WORLD JOURNAL OF GASTROENTEROLOGY Vol.24 No.5
<P>Dural metastasis from primary gastric adenocarcinoma has been rarely reported, and its prognosis is very poor because it frequently leads to acute subdural hematoma. Here, we describe a case with sequential spinal and cranial dural metastases from gastric adenocarcinoma without subdural hematoma. A 43-year-old woman with gastric adenocarcinoma and well-controlled peritoneal carcinomatosis presented with back pain, right radiating leg pain, left facial palsy, and hearing loss. Magnetic resonance imaging of the spine and brain revealed dural masses at the lumbosacral junction with invasion to the L5 and S1 nerve roots and at the skull base with invasion to the internal auditory canal. She was treated with local radiotherapy, and her pain and neurologic symptoms improved after palliative radiotherapy. This is the first reported case of dural metastases of gastric adenocarcinoma of the spine and skull base but with a relatively indolent course and without subdural hematoma.</P>
Kwon, Jihyun,Han, Hye Sook,Kim, Hee Kyung,Baek, Seung-Woo,Yang, Yaewon,Lee, Ki Hyeong,Son, Seung-Myoung,Kim, Won-Dong,Kim, Dae Hoon,Yun, Hyo Yung The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.3
We report a rare case of long-term survival in a patient who received local therapy and salvage chemotherapy for recurrent metastases, along with a literature review. A 65-year-old male patient underwent subtotal gastrectomy for advanced gastric adenocarcinoma. Six months after gastrectomy, 2 metastatic intra-abdominal lymph node enlargements were detected, which were treated with radiotherapy. At 55 months after gastrectomy, an abdominal wall mass was detected, which was treated by surgical resection. The patient received 5-fluorouracil/leucovorin/irinotecan chemotherapy for 27 months before and after radiotherapy and docetaxel chemotherapy for 6 months after surgical resection of the abdominal wall metastasis. At the last visit, 7.8 years since the initial resection of the primary gastric cancer and 6.2 years since detection of the first metastases, the patient was disease-free and required no further chemotherapy. This case suggests that repeated local therapy offers potential for long-term survival in a carefully selected subset of patients with recurrent metastases.
Min, Ahrum,Im, Seock-Ah,Jang, Hyemin,Kim, Seongyeong,Lee, Miso,Kim, Debora Keunyoung,Yang, Yaewon,Kim, Hee-Jun,Lee, Kyung-Hun,Kim, Jin Won,Kim, Tae-Yong,Oh, Do-Youn,Brown, Jeff,Lau, Alan,O'Connor, Mar American Association for Cancer Research 2017 Molecular Cancer Therapeutics Vol.16 No.4
<P>These findings suggest synthetic lethality between ATR inhibition and ATM deficiency in gastric cancer cells. Further clinical studies on the interaction between AZD 6738 and ATM deficiency are warranted to develop novel treatment strategies for gastric cancer. (C)2017 AACR.</P>
Min, Ahrum,Jang, Hyemin,Kim, Seongyeong,Lee, Kyung-Hun,Kim, Debora Keunyoung,Suh, Koung Jin,Yang, Yaewon,Elvin, Paul,O'Connor, Mark J.,Im, Seock-Ah American Association for Cancer Research 2018 Molecular cancer therapeutics Vol.17 No.12
<P>The androgen receptor (AR) is expressed in 60%–70% of breast cancers regardless of estrogen receptor status, and has been proposed as a therapeutic target in breast cancers that retain AR. In this study, the authors aimed to investigate a new treatment strategy using a novel AR inhibitor AZD3514 in breast cancer. AZD3514 alone had a minimal antiproliferative effect on most breast cancer cell lines irrespective of AR expression level, but it downregulated the expressions of DNA damage response (DDR) molecules, including ATM and chk2, which resulted in the accumulation of damaged DNA in some breast cancer cells. Furthermore, AZD3514 enhanced cellular sensitivity to a PARP inhibitor olaparib by blocking the DDR pathway in breast cancer cells. Furthermore, the downregulation of NKX3.1 expression in MDA-MB-468 cells by AZD3514 occurred in parallel with the suppression of ATM–chk2 axis activation, and the suppression of NKX3.1 by AZD3514 was found to result from AZD3514-induced TOPORS upregulation and a resultant increase in NKX3.1 degradation. The study shows posttranslational regulation of NKX3.1 via TOPORS upregulation by AZD3514-induced ATM inactivation–increased olaparib sensitivity in AR-positive and TOPORS-expressing breast cancer cells, and suggests the antitumor effect of AZD3514/olaparib cotreatment is caused by compromised DDR activity in breast cancer cell lines and in a xenograft model. These results provide a rationale for future clinical trials of olaparib/AR inhibitor combination treatment in breast cancer.</P>
Prognostic effects of abnormal DNA damage response protein expression in breast cancer
Suh, Koung Jin,Ryu, Han Suk,Lee, Kyung-Hun,Kim, Hyojin,Min, Ahrum,Kim, Tae-Yong,Yang, Yaewon,Lee, Han-Byoel,Moon, Hyeong-Gon,Han, Sae-Won,Oh, Do-Youn,Han, Wonshik,Park, In Ae,Noh, Dong-Young,Im, Seock Springer-Verlag 2019 Breast cancer research and treatment Vol.175 No.1