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소아 알레르기비염의 경제적 부담 평가를 위한 다기관 조사
공도연 ( Do Youn Kong ),김경원 ( Kyung Won Kim ),김우경 ( Woo Kyung Kim ),민택기 ( Taek Ki Min ),박용민 ( Yong Mean Park ),안재억 ( Jae Ouk Ahn ),양현종 ( Hyeon Jong Yang ),염혜영 ( Hye Yung Yum ),윤혜선 ( Hae Sun Yoon ),전유훈 ( 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.2
목적: 알레르기비염의 유병률은 전 세계적으로 급격히 증가하고 있으며, 그에 따른 경제적 부담도 증가하고 있다. 그러나, 소아 알레르기 질환이 미치는 경제적 부담에 관한 국내 연구는 제한적이어서 소아 알레르기비염이 환자와 그 가족에게 미치는 경제적 부담을 산출하고자 본 연구를 진행하였다. 방법: 2008년 7월 1일부터 9월 31일까지 서울시 6개 2-3차 의료기관을 방문한 18세 이하 소아 알레르기비염 환자 및 보호자를 대상으로 설문 조사를 진행하였다. 설문을 통해 직접 의료비 (병·의원 진료비, 및 약제비 한방 진료비 및 약제비, 보완/대체요법비), 직접비의료비 (교통비, 환경개선비), 그리고 간접비용 (월 평균 노동 손실)을 조사하였고 그 결과를 질환의 중증도 및 유병 기간에 따라 분석하여 그 차이를 비교하였다. 결과: 모집된 262명의 대상 중 174명(66.4%)이 남자였고, 평균 연령은 6.54세였다. 대상군의 연간 평균 직접 의료비는 177만 원이었고 직접비 의료비는 57만 원이었다. 비록 통계학적 유의성은 없었지만, 알레르기비염의 중증도가 증가할수록 직접 의료비가 증가하는 경향을 보였고, (P=0.053) 유병 기간 또한 직접 의료비의 증가와 유의한 양의 상관 관계를 보였다. (R=0.195, P=0.002) 대상 환자 보호자의 약 17%가 아이의 알레르기비염으로 인해 직장에 결근 또는 조퇴를 경험한 것으로 조사되어 사회적 간접비용을 미루어 생각할 수 있었다. 결론: 알레르기비염이 미치는 경제적 부담은 질환의 중증도가 심할수록, 그리고 유병 기간이 길수록 증가하며, 이는 특히 한방 진료 및 치료비와 보완/대체요법비의 증가에 기인한 것으로 조사되었다. 따라서 알레르기비염으로 인한 경제적 부담을 줄이기 위해서는 환자와 보호자를 대상으로 근거 중심의 치료를 할 수 있도록 지속적이고 체계적인 교육이 필요할 것으로 사료된다. Purpose: The prevalence of allergic rhinitis is rapidly increasing and results in relatively high socio-economic burden on their family and community. However, studies on the economic burden of pediatric allergic rhinitis in Korea are limited. Therefore, we conducted this study to investigate the impact of pediatric allergic rhinitis on economic burden. Methods: Two hundred sixty two children with allergic rhinitis were enrolled in 6 secondary or tertiary medical centers in Seoul from July to September, 2008. We collected data of the economic burden of allergic rhinitis (direct medical costs, direct nonmedical costs, and indirect costs) by face to face questionnaire survey. We compared the economic burden according to the severity and the duration of allergic rhinitis. Results: The mean age of subjects was 6.54 years, and male were 174 (66.4%). Direct medical costs (10,000 Korean Won/yr) were 177.75, and direct nonmedical costs were 57.92. Although, there was no statistical significance, direct medical costs showed increasing trends in severe allergic rhinitis. (P=0.053) In addition, direct medical costs were positively correlated with duration of allergic rhinitis.( R=0.195, P=0.002). About 17% of the parents who care the allergic rhinitis children experienced the work absence due to their child s illness. Conclusion: The economic burdens of allergic rhinitis were positively correlated with the severity and duration of illness. Particularly costs for alternative medicine including oriental medicine` were related with severity and duration allergic rhinitis. Therefore, special efforts for education with evidence based treatment strategy are necessary to decrease the economic burden of allergic rhinitis.
Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma in Korea
Jong Man KIM,Dong Jin JOO,Shin HWANG,Nam-Joon YI,Je Ho RYU,Yang Won NA,Dong-Sik KIM,Doo Jin KIM,Young Kyoung YOO,Hee Chul YU,Myoung Soo KIM 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-
Yang, Won,Yang, Dong Jin,Choi, Sin Young,Kim, Jong Soo American Chemical Society 2011 Energy & fuels Vol.25 No.6
<P>Co-firing synthesis gas (syngas) with conventional fuels within a conventional boiler is an effective method that partially replaces the use of fossil fuels with low-grade fuels or renewable energy sources such as waste or biomass. This study investigates the characteristics of syngas cofiring and reburning in a commercial oil-firing boiler and a pilot-scale vertical combustion chamber with refractory. Syngas cofiring was tested in two separate apparatus. The first was a commercial water-tube boiler containing one heavy oil burner of 0.7 MW<SUB>th</SUB> (for 1 ton steam/h). The second was a vertical furnace with 4 heavy oil burners, for various heat replacements by syngas cofiring at various heating values. Temperature distributions and the gas composition at the exit of the combustion chamber were measured for all cases and the thermal efficiencies under various cofiring conditions were evaluated through heat and mass balance calculations. Combustion stability remained unaffected if less than 20% heat was replaced by syngas cofiring; this was true for syngas of low calorific values (3.7 MJ/Nm<SUP>3</SUP>), and especially in vertical furnaces with horizontally installed multiburners. The reburning effects induced by syngas cofiring were confirmed by testing two reburning conditions in the vertical chamber: reburning only and reburning in combination with air-staged combustion of which the total thermal input was 2 MW<SUB>th</SUB>. These conditions reduced NO<SUB><I>x</I></SUB> emission by 30–50%, indicating that high temperatures of the radical production are essential for reducing NO<SUB><I>x</I></SUB> emissions. Meanwhile, syngases containing low-calorific values yielded heat efficiency losses. Conversely, heat efficiency increased when syngases possessing higher heating values were applied to the boiler.</P>
Jong-In Chang,Tae Jun Kim,Na Young Hwang,Insuk Sohn,Yang Won Min,Hyuk Lee,Byung-Hoon Min,Jun Haeng Lee,Poong-Lyul Rhee,Jae J Kim 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.1
Background/Aims: Endoscopic submucosal dissection (ESD) of gastric tumors in the mid-to-upper stomach is a technicallychallenging procedure. This study compared the therapeutic outcomes and adverse events of ESD of tumors in the mid-to-upperstomach performed under general anesthesia (GA) or monitored anesthesia care (MAC). Methods: Between 2012 and 2018, 674 patients underwent ESD for gastric tumors in the midbody, high body, fundus, or cardia (100patients received GA; 574 received MAC). The outcomes of the propensity score (PS)-matched (1:1) patients receiving either GA orMAC were analyzed. Results: The PS matching identified 94 patients who received GA and 94 patients who received MAC. Both groups showed highrates of en bloc resection (GA, 95.7%; MAC, 97.9%; p=0.68) and complete resection (GA, 81.9%; MAC, 84.0%; p=0.14). There wereno significant differences between the rates of adverse events (GA, 16.0%; MAC, 8.5%; p=0.18) in the anesthetic groups. Logisticregression analysis indicated that the method of anesthesia did not affect the rates of complete resection or adverse events. Conclusions: ESD of tumors in the mid-to-upper stomach at our high-volume center had good outcomes, regardless of the methodof anesthesia. Our results demonstrate no differences between the efficacies and safety of ESD performed under MAC and GA.
Yang, Kyung Min,Pyo, Jong Ok,Kim, Gyu-Yeol,Yu, Rina,Han, In Seob,Ju, Seong A.,Kim, Won Ho,Kim, Byung-Sam SP Versita 2009 Cellular & molecular biology letters Vol.14 No.3
<P>Although genetic factors are a well-known cause of colorectal cancer, environmental factors contribute more to its development. Despite advances in the fields of surgery, radiotherapy and chemotherapy, the cure rates for colon cancer have not substantially improved over the past few decades. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the principal pungent ingredient of hot chili pepper, has exhibited an anti-tumor effect in many cell types. However, the mechanisms responsible for the anti-tumor effect of capsaicin are not yet completely understood. In this study, we investigated whether capsaicin induces apoptosis in colon cancer cell lines. Capsaicin decreased cell viability in a dose-dependent manner in Colo320DM and LoVo cells. In addition, capsaicin produced cell morphology changes and DNA fragmentation, decreased the DNA contents, and induced phosphatidylserine translocation, which is a hallmark of apoptotic cell death. We showed that capsaicin-induced apoptosis is associated with an increase in ROS generation and a disruption of the mitochondrial transmenbrane potential. A possible mechanism of capsaicin-induced apoptosis is the activation of caspase 3, a major apoptosis-executing enzyme. Treatment with capsaicin induced a dramatic increase in caspase 3 activity, as assessed by the cleavage of Ac-DEVD-AMC, a fluorogenic substrate. In conclusion, our results clearly showed that capsaicin induced apoptosis in colon cancer cells. Although the actual mechanisms of capsaicin-induced apoptosis remain uncertain, it may be a beneficial agent for colon cancer treatment and chemoprevention.</P>
Jong-Ho Choi,Sang-Uk Han,Han-Kwang Yang,Young-Woo Kim,Keun Won Ryu,Joong-Min Park,Ji Yeong An,Min-Chan Kim,Sungsoo Park,Kyo Young Song,Sung Jin Oh,Seong-Ho Kong,Byoung Jo Suh,Dae Hyun Yang,Tae Kyung H 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.5
Purpose: Quality of life (QOL) has become important in the trend of emphasizing patient satisfaction. This study aimed to evaluate the QOL in patients who underwent laparoscopic or robotic gastrectomy for gastric cancer. Methods: A prospective trial was performed involving patients who underwent laparoscopic or robotic gastrectomy for primary gastric cancer at 11 hospitals in Korea. Within this comparative trial, QOL, postoperative pain, and long-term complications were exanimated. The quality-of-life questionnaire (QLQ)-C30 and QLQ-STO22 developed by the European Organization for Research and Treatment of Cancer were used for the QOL survey. We compared the data after dividing it into several types of characteristics as follows; device (robotic or laparoscopic), operation type, pathological stage, and sex. Biased components were extracted by logistic regression analysis. Propensity score matching was applied to the data set with the biased components. Results: In total, 434 patients (211 for laparoscopic surgery and 223 for robotic surgery) were enrolled, out of which 321 patients who responded to both preoperative and postoperative surveys were selected for analysis. Robotic gastrectomy was not different from laparoscopic gastrectomy with respect to postoperative QOL. Distal gastrectomy showed better scores than total gastrectomy in terms of role functioning, social functioning, fatigue, nausea/vomiting, pain, dyspnea, constipation, financial difficulties, dysphagia, eating restrictions, anxiety, taste, and body image. Male patients showed better scores on the 19 scales compared to female patients. Conclusion: Robotic and laparoscopic approaches for gastric cancer surgery did not differ from each other with respect to QOL. Distal gastrectomy resulted in better QOL than total gastrectomy.
Jong-Min Park,Min-Sun Jang,Bonuk Koo,Hea-Ran Kim,Young-Tae Kwon,Sangsun Yang,Jung Woo Lee,Jae Won Jeong 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Soft magnetic composite (SMC) has the advantages of excellent magnetic properties and the three dimensions shape core manufacturing with insulation coated Fe powder. In addition, SMC is attractive because it can overcome the output density limit of the currently produced electric motors made with two dimensions shape electrical steel plate. In the case of SMCs, comprising Fe@PO₄ powders, which is currently widely used, heat treatment above 650 °C damage of insulation properties. In order to solve this problem, this study focused on manufacturing SMC with low core loss characteristics, excellent magnetic properties, and maintaining insulation at heat treatment above 650 °C. Herein, SiO₂ coating was performed on the surface of Fe powder to reduce eddy current loss. Fe powder was coated with tetraethyl orthosilicate by sol-gel method, and core was prepared by pressing and heat treatment for 1 hour at 600 °C, 700 °C, and 800 °C in the argon atmosphere. The phase identification was carried out by X-ray diffractometer (XRD) and the insulation coating layer was measured by scanning electron microscope and energy dispersive X-ray spectroscopy. Also, magnetic characteristics were figured out through vibrating sample magnetometer (VSM) as well as the core loss value were compared for each frequency band; 0.05 kHz, 0.4 kHz, and 1 kHz using AC BH analyzer (AC) and DC BH loop tracer (DC). XRD patterns were observed the α-Fe peak, VSM results suggested that the saturation magnetization value was reduced, which confirmed the existence of coating layers. The results of AC and DC measurements on the cores heat-treated at 600 °C, 700 °C, and 800 °C have presented that core loss increase rate is higher for the Fe@PO₄ than that for the Fe@SiO₂ because SiO₂ has superior ability to retain the coating layer at high temperature. Therefore, SiO₂ coated Fe powder has potential in high temperature atmosphere applications.