http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
양재식(Jaesik Yang),염기태(Kitae Yeom),배충식(Choongsik Bae),김현옥(Hyunok Kim) 한국자동차공학회 2007 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This research presents a simulation for the fuel economy of parallel diesel hybrid vehicle. Diesel engines compared to gasoline engines have the advantages of higher fuel economy and lower CO₂ emission. One of the most ways to meet future fuel economy and emissions regulation is to combine diesel engine technology with a hybrid electric vehicle. The simulation of HEV is growing need for rapid analysis of the many configurations and component options. WAVE, a one-dimensional engine analysis tool, was used to a 2.7L diesel engine. ADVISOR, designed for rapid analysis of the performance and fuel economy of vehicle models, was used to conventional and hybrid electric vehicle by the use of output file from WAVE as the input engine data file for ADVISOR. A parallel diesel HEV is at least 19.7~36% higher fuel economy and improved acceleration ability compared to a conventional diesel vehicle. The energy loss of the parallel diesel HEV is 23~38% less than the conventional vehicle using regeneration.
Ji Young Kim,Youngran Yang,Hyunok Kim,Seok Hee Jeong,Ju-Hee Nho 한국성인간호학회 2021 성인간호학회 학술대회 Vol.2021 No.8
Aim(s): The present study aimed to assess the risk of incidence of metabolic syndrome depending on the body size phenotype of Korean adults. Method(s): The longitudinal study included 5,068 metabolically healthy subjects from the Korean Genome and Epidemiology Study (KoGES), which was tracked every two years from 2001 to 2016. After removing individuals with metabolic syndrome from the baseline and missing data, the sample size for analysis was n = 2,216. Analysis was performed using the log-rank test, life table method, Cox proportional hazards regression model, and time-dependent Cox proportional hazards regression model. IBM SPSS Statistics version 26 was used for the analysis. Result(s): The incidence of metabolic syndrome was 41.5% among males and 43.3% among females when followed for 14 years. The incidence of metabolic syndrome depending on the body size phenotype significantly differed in males (F = 92.83, p < .001) and females (F = 81.48, p < .001). Compared with the metabolically healthy normal weight (MHNW) group, the hazard ratio (HR) for the risk of incidence of metabolic syndrome was 1.96 (95% CI = 1.67–2.30, p < .001) in the metabolically healthy overweight (MHOW) group and 3.11 (95% CI = 2.67–3.63, p < .001) in the metabolically healthy obese (MHO) group in males, while it was 1.89 (95% CI = 1.58–2.28, p < .001) in the MHOW group and 2.70 (95% CI = 2.28–3.21, p < .001) in the MHO group in females. In the time-dependent model, compared with the MHNW group, the HR was 1.92 (95% CI = 1.54–2.40, p < .001) in the MHOW group and 2.88 (95% CI = 2.32–3.58, p < .001) in the MHO group in males, while it was 1.89 (95% CI = 1.51–2.37, p < .001) in the MHOW group and 2.34 (95% CI = 1.88–2.90, p < .001) in the MHO group in females. Conclusion(s): The results of the present study are expected to aid the development of interventions and policies for the prevention of metabolic syndrome and for obesity management in Korea in the future.
Lee, Daekee,Yu, Ming,Lee, Eunjung,Kim, Hyunok,Yang, Yanan,Kim, Kyoungmi,Pannicia, Christina,Kurie, Jonathan M.,Threadgill, David W. American Society for Clinical Investigation 2009 The Journal of clinical investigation Vol.119 No.9
<P>Pharmacologic blockade of EGFR or the closely related receptor ERBB2 has modest efficacy against colorectal cancers in the clinic. Although the upregulation of ERBB3, a pseudo-kinase member of the EGFR/ERBB family, is known to contribute to EGFR inhibitor resistance in other cancers, its functions in normal and malignant intestinal epithelium have not been defined. We have shown here that the intestinal epithelium of mice with intestine-specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of expression of ERBB4 and sensitivity to intestinal damage. By contrast, intestine-specific Erbb3 ablation resulted in almost complete absence of intestinal tumors in the ApcMin mouse model of colon cancer. Unlike nontransformed epithelium lacking ERBB3, intestinal tumors lacking ERBB3 had reduced PI3K/AKT signaling, which led to attenuation of tumorigenesis via a tumor-specific increase in caspase-3-mediated apoptosis. Consistent with the mouse data, which suggest that ERBB3-ERBB4 heterodimers contribute to colon cancer survival, experimentally induced loss of ERBB3 in a KRAS mutant human colon cancer cell line was associated with loss of ERBB4 expression, and siRNA knockdown of either ERBB3 or ERBB4 resulted in elevated levels of apoptosis. These results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ERBB3 may be a promising target for the treatment of colorectal cancers.</P>