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Practice of Design Curriculum Aimed for High Attainment Level of Creativity and Perfection
Yagi, Hidetsugu,Arimitsu, Yutaka Korean Society for Engineering Education 2010 공학교육연구 Vol.13 No.2
The practice named "Creative Design and Production" has been given to train the students'ability to find and solve problems. Students are expected to design and fabricate creative artifacts in the practice. The practices focusing on perfection and creativity of the products have been executed for the past few years. We have reviewed the relationships between these abilities and the qualities of products of the students in the practices. It seems that the products lacks of originality and creativity when focused on the perfection. And on the contrary, the perfection of the products is low when focused on the creativity. We have employed the new three trials in order to solve these problems in the practice. Among trials, the cooperation with veterans has been the most useful for students through "Creative Design and Production".
Yagi Sen,Furukawa Shinya,Shiraishi Kana,Miyake Teruki,Tange Kazuhiro,Hashimoto Yu,Kitahata Shogo,Kawamura Tomoe,Ninomiya Tomoyuki,Mori Kenichirou,Suzuki Seiyuu,Shibata Naozumi,Murakami Hidehiro,Ohashi 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.2
Purpose: The albumin-to-globulin ratio (AGR) is a recognized chronic inflammation marker. No evidence regarding the relationship between AGR level and ulcerative colitis (UC) exists. The aim of this study was to evaluate the association between AGR and clinical outcomes among Japanese subjects with UC. Methods: The study subjects consisted of 273 Japanese individuals with UC. AGR was divided into 4 categories (low, moderate, high, and very high). The definition of complete mucosal healing (MH) was based on the Mayo endoscopic subscore of 0. Clinical remission (CR) was defined as no rectal bleeding and no abnormally high stool frequency (<3 times per day). Results: The percentage of MH was 26.4%. High AGR and very high AGR were significantly positively correlated with CR (adjusted odds ratio [OR], 5.85; 95% confidence interval [CI], 2.52–14.18 and adjusted OR, 4.97; 95% CI, 2.14–12.04) and complete MH (adjusted OR, 4.03; 95% CI, 1.56–11.51 and adjusted OR, 5.22; 95% CI, 1.97–14.89), respectively after adjustment for confounding factors (P for trend=0.001). Only in the low C-reactive protein (CRP) group (≤0.1 mg/dL), very high AGR was significantly positively correlated with complete MH but not CR (adjusted OR, 4.38; 95% CI, 1.06–21.77; P for trend=0.017). In the high CRP group, no correlation between AGR and complete MH was found. Conclusion: Among Japanese patients with UC, AGR may be independently positively correlated with complete MH. In particular, among UC patients with low CRP, AGR might be a useful complementary marker for complete MH.
Yagi Kiyoshi,Goto Yuta,Kato Kenji,Suzuki Nobuyuki,Kondo Akira,Waseda Yuya,Mizutani Jun,Kawaguchi Yohei,Joyo Yuji,Waguri-Nagaya Yuko,Murakami Hideki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.6
Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.
Yagi, kashi,Fujikawa, Yoshihiro,Sawai, Tomoko,Takamura-Enya, Takeji,Ito-Harashima, Sayoko,Kawanishi, Masanobu Korean Society of ToxicologyKorea Environmental Mu 2017 Toxicological Research Vol.33 No.4
Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the $N^2$ or C8 positions of guanine or the $N^6$ position of adenine. The proportion of $N^2$ and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS). TLS is performed by translesion DNA polymerases-Pol ${\eta}$, ${\kappa}$, ${\iota}$, and ${\zeta}$ and Rev1-in an error-free or error-prone manner. Regarding the NBA adducts, namely, 2-(2'-deoxyguanosin-$N^2$-yl)-3-aminobenzanthrone (dG-$N^2$-ABA) and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-ABA), dG-$N^2$-ABA is produced more often than dG-C8-ABA, whereas dG-C8-ABA blocks DNA replication more strongly than dG-$N^2$-ABA. dG-$N^2$-ABA allows for a less error-prone bypass than dG-C8-ABA does. Pol ${\eta}$ and ${\kappa}$ are stronger contributors to TLS over dG-C8-ABA, and Pol ${\kappa}$ bypasses dG-C8-ABA in an error-prone manner. TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). Elucidation of the general mechanisms determining efficiency, error-proneness, and the polymerases involved in TLS over various adducts is the next step in the research on TLS. These TLS studies will clarify the mechanisms underlying aryl hydrocarbon mutagenesis and carcinogenesis in more detail.
Improving Flow Distribution in a Suction Channel for a Highly Efficient Centrifugal Compressor
Yagi, Manabu,Shibata, Takanori,Kobayashi, Hiromi,Tanaka, Masanori,Nishida, Hideo Korean Society for Fluid machinery 2012 International journal of fluid machinery and syste Vol.5 No.3
Design parameters for suction channels of process centrifugal compressors were investigated, and an optimization method to enhance stage efficiency by using the new design parameters was proposed. From results of computational fluid dynamics, the passage sectional area ratios $A_c/A_e$, $A_e/A_s$ and $A_c/A_s$ were found to be the dominant parameters for the pressure loss and circumferential flow distortion, where $A_c$, $A_e$ and $A_s$ are passage sectional areas for the casing upstream side, casing entrance and impeller eye, respectively. The Base suction channel was optimized using the new design parameters, and the Base and Optimized types were tested. Test results showed that the Optimized suction channel achieved 3.8% higher stage efficiency than the Base suction channel while maintaining the same operating range.
Molecular catalysts for water oxidation toward artificial photosynthesis
Yagi, Masayuki,Syouji, Akinori,Yamada, Satoshi,Komi, Manabu,Yamazaki, Hirosato,Tajima, Syouhei Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.2
Artificial photosynthesis is anticipated as one of the promising clean energy-providing systems for the future. The development of an efficient catalyst for water oxidation to evolve $O_2$ is a key task to yield a breakthrough for construction of artificial photosynthetic devices. Recently, significant progress has been reported in the development of the molecular catalysts for water oxidation based on manganese, ruthenium and iridium. The molecular aspects of the catalysts reported in the last decade were reviewed to provide hints to design an efficient catalyst, as well as to gain clues to reveal the mechanism of $O_2$ evolution at photosynthetic oxygen evolving complex in nature.