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RISS 인기검색어
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- 저자 : Yafang Kang (검색결과 3 건)
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Yafang Kang,Pengming Sun,Xiaodan Mao,Binhua Dong,Guanyu Ruan,Lihua Chen 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3
Objective: To evaluate the polymerase chain reaction (PCR)-reverse-dot-blot (RDB) human papillomavirus (HPV) genotyping test as a feasible assay for the cervical cancer primary screening. Methods: In a hospital-based cohort, a total of 21,568 women were voluntarily enrolled from March 2009 to November 2016 for evaluating the 3 current cervical cancer screening strategies: co-test, cytology primary and high-risk HPV (HR-HPV) primary by using PCRRDB HPV genotyping and liquid-based cytology (thinprep cytologic test [TCT]). Women with HR-HPV infection and/or abnormal cytology were referred for colposcopy, and the biopsy or conization was performed according to the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines. Results: Overall, 18.20% (3,935/21,568) of the women were detected as HR-HPVpositive, 5.04% (1,088/21,568) were diagnosed with cervical intraepithelial neoplasia 2 or higher (CIN2+), and 3.43% (739/21,568) with CIN3+. The cumulative incidence rates for CIN2+/CIN3+ in patients with HPV-16/18-positive were 48.28%/37.20%, while they were 0.86%/0.38%, 0.30%/0.15% and 0.18%/0.09% in cytology-negative, HR-HPV-negative and co-test-negative population, respectively. Using CIN2+ and CIN3+ as the observed endpoints, the sensitivity and negative predictive value (NPV) of HR-HPV genotyping as a primary screening tool were 90.99%/99.49% and 91.57%/99.80%. Moreover, using HR-HPV genotyping primary screening could detect the same more CIN2+/CIN3+ cases in baselinedetection as co-testing (990/700 vs. 991/701) and far more than cytology primary screening (903/656, p<0.05). It also achieved the lowest misdiagnosis rate (8.01%/5.02%). Although HPV genotyping primary screening required an increased number of colposcopies (2.75/3.89 per CIN2+/CIN3+ case), it yielded an acceptable rate. Conclusions: The PCR-RDB HPV genotyping test is a cost-effective and beneficial cervical cancer primary screening for hospital-based opportunistic screening.
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Qiang Huang,Yongwang Kang,Jinxia Song,Shiyu Qu,Yafang Han,Xiping Guo 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.3
Nb-Si in situ composites with a nominal composition of Nb-22Ti-12Si-X (at.%, X represents Ni, Co, B, or Ge)are prepared using non-consumable arc melting technology. The effects of the alloying elements on themicrostructures and mechanical properties are investigated. The Nb-22Ti-12Si ternary alloy consists of Nbss andNb3Si. A new phase of Ti2Ni or Ti2Co is introduced into the ternary system after adding Ni or Co. The addition of6% Ge promotes the formation of Nb5Si3 and creates significantly finer microstructures. The values of the hightemperature strength and room temperature fracture toughness of Nb-22Ti-12Si-6Ge are 566.33MPa and12.81MPa·m1/2, respectively, which are approximately 88.2% and 18.5% higher than those of Nb-22Ti-12Si(300.98 MPa and 10.81 MPa·m1/2). The addition of 3% B changed the morphological features and inducedthe appearance of large fine rosettes, which is favorable for restraining the crack propagation, and it also leadsto a 22.3% increase in room temperature fracture toughness compared with the Nb-22Ti-12Si ternaryalloy.
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Pengming Sun,Yiyi Song,Guanyu Ruan,Xiaodan Mao,Yafang Kang,Binhua Dong,Fen Lin 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: To determine the clinical significance of the polymerase chain reaction (PCR)-reverse dot blot (RDB) human papillomavirus (HPV) genotyping assay in cervical cancerscreening. Methods: A total of 10,442 women attending the Fujian Provincial Maternity and Children'sHealth Hospital were evaluated using the liquid-based cytology (thinprep cytologic test[TCT]) and the PCR-RDB HPV test. Women with HPV infection and/or abnormal cytologywere referred for colposcopy and biopsy. For HPV DNA sequencing, 120 specimens wererandomly selected. Pathological diagnosis was used as the gold standard. Results: Using the PCR-RDB HPV test, overall HPV prevalence was 20.57% (2,148/10,442)and that of high-risk (HR)-HPV infection was 18.68% (1,951/10,442). There was 99.2%concordance between HPV PCR-RDB testing and sequencing. In this studied population,the most common HR-HPV types were HPV-16, -52, -58, -18, -53, -33, and -51, rank fromhigh to low. HPV-16, -18, -58, -59, and -33 were the top 5 prevalent genotypes in cervicalcancer but HPV-16, -18, -59, -45, and -33 were the top 5 highest risk factors for cancer (oddsratio [OR]=34.964, 7.278, 6.728, 6.101, and 3.658; all p<0.05, respectively). Among 10,442cases, 1,278 had abnormal cytology results, of which, the HR-HPV positivity rate was 83.02%(1,061/1,278). To screen for cervical cancer by PCR-RDB HPV testing, when using CIN2+,CIN3+, and cancer as observed endpoints, the sensitivity was 90.43%, 92.61%, and 94.78%and the negative predictive value (NPV) was 99.06%, 99.42%, and 99.78%, respectively. PCRRDBHPV and TCT co-testing achieved the highest sensitivity and NPV. Conclusion: For cervical cancer screening, the PCR-RDB HPV test can provide a reliable andsensitive clinical reference.
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