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Choi, E. M.,Cui, Y. H.,Kwon, S. H.,Kim, A. R.,Choi, H. S.,Lee, S. J.,Pyo, S. G. John Wiley Sons, Ltd 2014 Physica Status Solidi. Rapid Research Letters Vol.8 No.2
We report the development of a Ti-Ti bonding process at a low bonding temperature below 200 degrees C using chemically surface-activated Ti thin films and a reliable evaluation method for measuring the Ti-Ti bond strength by means of atomic force microscopy (AFM). Using Ti as an interlayer enables void-free bonding because Ti exhibits fast diffusion and oxide solubility. On the other hand, wafer bonding is an important processing step for 3D circuit integration that requires a high reliability of the process. However, the reliability of bonding-strength values obtained by employing conventional measurement devices is limited by comparably large measurement errors and restricted the availability of suitable sample material. In this study, the use of AFM to measure the bonding strength is proposed. The interfacial bonding properties depend on the Ti deposition parameters. A bonding temperature of 200 degrees C was found to be appropriate for the development of a low bonding temperature wafer-bonding process. The pretreatment methods like plasma activation and chemical activation at 200 degrees C result in a Ti bonding strength of approximately 8.22 J/m(2), sufficient for applications in 3D circuit integration. ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Cui, Y-H,Suh, Y,Lee, H-J,Yoo, K-C,Uddin, N,Jeong, Y-J,Lee, J-S,Hwang, S-G,Nam, S-Y,Kim, M-J,Lee, S-J Macmillan Publishers Limited 2015 Oncogene Vol.34 No.42
Despite ionizing radiation (IR) is being widely used as a standard treatment for lung cancer, many evidences suggest that IR paradoxically promotes cancer malignancy. However, its molecular mechanisms underlying radiation-induced cancer progression remain obscure. Here, we report that exposure to fractionated radiation (2 Gy per day for 3 days) induces the secretion of granulocyte-colony-stimulating factor (G-CSF) that has been commonly used in cancer therapies to ameliorate neutropenia. Intriguingly, radiation-induced G-CSF promoted the migratory and invasive properties by triggering the epithelial–mesenchymal cell transition (EMT) in non-small-cell lung cancer cells (NSCLCs). By irradiation, G-CSF was upregulated transcriptionally by β-catenin/TCF4 complex that binds to the promoter region of G-CSF as a transcription factor. Importantly, irradiation increased the stability of β-catenin through the activation of PI3K/AKT (phosphatidylinositol 3-kinase/AKT), thereby upregulating the expression of G-CSF. Radiation-induced G-CSF is recognized by G-CSFR and transduced its intracellular signaling JAK/STAT3 (Janus kinase/signal transducers and activators of transcription), thereby triggering EMT program in NSCLCs. Taken together, our findings suggest that the application of G-CSF in cancer therapies to ameliorate neutropenia should be reconsidered owing to its effect on cancer progression, and G-CSF could be a novel therapeutic target to mitigate the harmful effect of radiotherapy for the treatment of NSCLC.
J.L. Cui,Y.M. Yan,H. Fu,X.J. Zhang,Y.L. Gao,Y. Deng 한국물리학회 2012 Current Applied Physics Vol.12 No.1
We have performed a comparative investigation of the series compounds (InSb)nCum to assess the roles of Cu addition on the thermoelectric properties and nanostructuring in bulk InSb. Detailed temperature dependent transport properties including electrical conductivity, the Seebeck coefficient, and thermal conductivity are presented. The Seebeck coefficients of In20Sb20Cu (m:n ¼ 1:20) are increased by 13percent in magnitude if compared to those of InSb, which is responsible for the 22 percent enhancement in the highest ZT value at 687 K. Although the magnitudes of kL are larger than those of InSb over the entire temperature range, a remarkable reduction in lattice thermal conductivities (kL) was observed with measuring temperature elevation. Such changes are mainly due to the precipitation of a large number of Cu9In4 nanoparticles with the size of smaller than 5 nm, dispersed in the matrix observed using high resolution transmission electron microscopy (HRTEM) images.
Cui, H.S.,Joo, S.Y.,Lee, D.H.,Yu, J.H.,Jeong, J.H.,Kim, J.B.,Seo, C.H. Academic Press 2017 Archives of biochemistry and biophysics Vol.630 No.-
Numerous studies on the application of low temperature plasma (LTP) have produced impressive results, including antimicrobial, antitumor, and wound healing effects. Although LTP research has branched out to include medical applications, the detailed effects and working mechanisms of LTP on wound healing have not been fully investigated. Here, we investigated the potential effect of inducing growth factor after exposure to LTP and demonstrated the increased expression of angiogenic growth factor mediated by LTP-induced HIF1α expression in primary cultured human dermal fibroblasts. In cell viability assays, fibroblast viability was reduced 6 h and 24 h after LTP treatment for only 5 min, and pre-treating with NAC, a ROS scavenger, prevented cell loss. Fibroblast migration significantly increased at 6 h and 24 h in scratch wound healing assays, the expression of cytokines significantly changed, and regulatory growth factors were induced at 6 h and 24 h after exposure to LTP in RT-PCR or ELISAs. Specifically, LTP treatment significantly induced the expression of HIF1α, an upstream regulator of angiogenesis. Pre-treatment with the inhibitor CAY10585 abolished HIF1α expression and prevented LTP-induced angiogenic growth factor production according to immunoblotting, immunocytochemistry, and ELISA results. Taken together, our results provide information on the molecular mechanism by which LTP application may promote angiogenesis and will aid in developing methods to improve wound healing.
TWO-LAYER DISTRIBUTED EQUALIZATION MANAGEMENT SYSTEM FOR ELECTRIC VEHICLE POWER BATTERY
J. Y. CUI,X. W. ZHANG 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.6
The battery inconsistency affects the lifetime of the battery, and the equalization management system can improve the battery inconsistency, but the present equalization management schemes cannot solve the battery inconsistency problem well. A two-layer distributed electric vehicle power battery equalization management system is proposed in this paper, and the equalization circuit is designed and the related control strategy is given. On the aspect of equalization circuit design, the two-layer distributed topology with top and bottom layers is designed. The coaxial multi-winding DC-DC converter is used to achieve energy transfer between the top-layer modules. The capacity and resistance equalizations are used to charge when the voltage between the cells in the bottom-layer modules is low, and discharge when the voltage is high. For the equalization control strategy design, the cell voltage, battery SOC and battery voltage dispersion are used to control the equalization process, and different equalization standards are selected according to different battery work states. Specially, during the discharge period, the electric vehicle running status is considered, and the voltage difference between the cells in the module is used to calculate the equalization step, and the equalization operation is conducted layer-by-layer and step-bystep. Finally, the resistance equalization system, the capacity equalization system and the two-layer distributed equalization system were tested on a battery with 12 cells. Before the equalization, the maximum voltage deviation among the cells was 90 mV. After two hours’ equalization operation, the maximum voltage deviation was reduced to 25 mV for the two-layer distributed equalization system, to 36 mV for the capacity equalization system and to 37 mV for the resistance equalization system. The test results indicate that the proposed equalization system has the highest equalization speed and efficiency.
Cui, M.H.,Yoo, K.S.,Hyoung, S.,Nguyen, H.T.K.,Kim, Y.Y.,Kim, H.J.,Ok, S.H.,Yoo, S.D.,Shin, J.S. North-Holland Pub ; Elsevier Science Ltd 2013 FEBS letters Vol.587 No.12
We have characterized the function of a plant R2R3-MYB transcription factor, Arabidopsis thaliana MYB20 (AtMYB20). Transgenic plants overexpressing AtMYB20 (AtMYB20-OX) enhanced salt stress tolerance while repression lines (AtMYB20-SRDX) were more vulnerable to NaCl than wild-type plants. Following NaCl treatment, the expressions of ABI1, ABI2 and AtPP2CA, which encode type 2C serine/threonine protein phosphatases (PP2Cs) that act as negative regulators in abscisic acid (ABA) signaling, were suppressed in AtMYB20-OX but induced in AtMYB20-SRDX. The electrophoretic mobility shift assay results revealed that AtMYB20 binds to the promoter regions containing the MYB recognition sequence (TAACTG) and an ACGT core element of ABI1 and AtPP2CA. These findings suggest that AtMYB20 down-regulates the expression of PP2Cs, the negative regulator of ABA signaling, and enhances salt tolerance.