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An alternative spliced mouse presenilin-2 mRNA encodes a novel γ-secretase inhibitor
Suzuki, Y.,Ohta, K.,Itoh, M.,Sakoh-Sumitomo, Y.,Mitsuda, T.,Ueda, M.,Hayakawa-Yano, Y.,Li, S.,Hida, Y.,Inuzuka, T.,Jung, Y.K.,Nakagawa, T. North-Holland Pub ; Elsevier Science Ltd 2009 FEBS letters Vol.583 No.9
The γ-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical for the development of Alzheimer's disease (AD). PSs are autoproteolytically cleaved, producing an N-terminal fragment (NTF) and a hydrophilic loop domain-containing C-terminal fragment. However, the role of the loop domain in the γ-secretase complex assembly remains unknown. Here, we report a novel PS2 isoform generated by alternative splicing, named PS2β, which is composed of an NTF with a hydrophilic loop domain. PS2β disturbed the interaction between NCT and APH-1, resulting in the inhibition of amyloid-β production. We concluded that PS2β may inhibit γ-secretase activity by affecting the γ-secretase complex assembly. Structured summary: MINT-7025654: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with PEN2 (uniprotkb:Q9NZ42), PS2 beta (uniprotkb:Q61144-2) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007) MINT-7025631: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with NCT (uniprotkb:Q92542), PEN2 (uniprotkb:Q9NZ42) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007)
Mesonic and nonmesonic weak decay widths of medium-heavy <tex> $ \Lambda $</tex> hypernuclei
Sato, Y.,Ajimura, S.,Aoki, K.,Bhang, H.,Hasegawa, T.,Hashimoto, O.,Hotchi, H.,Kim, Y. D.,Kishimoto, T.,Maeda, K.,Noumi, H.,Ohta, Y.,Omata, K.,Outa, H.,Park, H.,Sekimoto, M.,Shibata, T.,Takahashi, T.,Y American Physical Society 2005 PHYSICAL REVIEW C - Vol.71 No.2
DEVELOPMENT OF INVERTER AND POWER CAPACITORS FOR MILD HYBRID VEHICLE(MHV)-TOYOTA"CROWN"
Y. SHIDA,M. KANDA,K. OHTA,S. FURUTA,J. ISHII 한국자동차공학회 2003 International journal of automotive technology Vol.4 No.1
The 42V Mild Hybrid System has been released into market by Toyota for the first time in the world in 2001. The set-up employs an inverter unit to control the motor/generator (MG) electronically. The driving system called such as Toyota Mild Hybrid System (TMHS) has additional new functions to conventional internal combustion engines. When stopping vehicle, the engine stops promptly. When starting vehicle. by releasing the brake pedal MG starts the vehicle at the same time (EV-driving mode). When stepping on the accelerator pedal. or after a given period of time the engine firing occurs and the engine-driving mode starts. When running by motor. the power is supplied to the motor from 36V battery through the inverter. High outputs and instant responses are required for Inverter. At the same time. the compact volume is required to fit into the limited space of the engine room. The compact size and high output are also required to Power Capacitor used for this inverter. The power capacitors has been newly developed. shaped in "flat" type. suitably for the inverter. The points of developments on inverter and power capacitor are described in this paper<br/>
TP53, MSH4, and LATS1 Germline Mutations in a Family with Clustering of Nervous System Tumors
Kim, Y.H.,Ohta, T.,Oh, J.E.,Le Calvez-Kelm, F.,McKay, J.,Voegele, C.,Durand, G.,Mittelbronn, M.,Kleihues, P.,Paulus, W.,Ohgaki, H. American Association of Pathologists and Bacteriol 2014 The American journal of pathology Vol.184 No.9
Exome DNA sequencing of blood samples from a Li-Fraumeni family with a TP53 germline mutation (codon 236 deletion) and multiple nervous system tumors revealed additional germline mutations. Missense mutations in the MSH4 DNA repair gene (c.2480T>A; p.I827N) were detected in three patients with gliomas (two anaplastic astrocytomas, two glioblastomas). Two family members without a TP53 germline mutation who developed peripheral schwannomas also carried the MSH4 germline mutation, and in addition, a germline mutation of the LATS1 gene (c.286C>T; p.R96W). LATS1 is a downstream mediator of the NF2, but has not previously been found to be related to schwannomas. We therefore screened the entire coding sequence of the LATS1 gene in 65 sporadic schwannomas, 12 neurofibroma/schwannoma hybrid tumors, and 4 cases of schwannomatosis. We only found a single base deletion at codon 827 (exon 5) in a spinal schwannoma, leading to a stop at codon 835 (c.2480delG; p.*R827Kfs*8). Mutational loss of LATS1 function may thus play a role in some inherited schwannomas, but only exceptionally in sporadic schwannomas. This is the first study reporting a germline MSH4 mutation. Since it was present in all patients, it may have contributed to the subsequent acquisition of TP53 and LATS1 germline mutations.
DEVELOPMENT OF INVERTER AND POWER CAPACITORS FOR MILD HYBRID VEHICLE (MHV) - TOYOTA "CROWN"
Shida, Y.,Kanda, M.,Ohta, K.,Furuta, S.,Ishii, J. The Korean Society of Automotive Engineers 2003 International journal of automotive technology Vol.4 No.1
The 42V Mild Hybrid System has been released into market by Toyota for the first time in the world in 2001. The set-up employs an inverter unit to control the motor/generator (MG) electronically. The driving system called such as Toyota Mild Hybrid System (TMHS) has additional new functions to conventional internal combustion engines. When stopping vehicle, the engine stops promptly. When starting vehicle, by releasing the brake pedal MG starts the vehicle at the same time (EV-driving mode). When stepping on the accelerator pedal, or after a given period of time the engine firing occurs and the engine-driving mode starts. When running by motor, the power is supplied to the motor from 36V battery through the inverter. High outputs and instant responses are required for Inverter. At the same time, the compact volume is required to fit into the limited space of the engine room. The compact size and high output are also required to Power Capacitor used for this inverter. The power capacitors has been newly developed, shaped in "flat" type, suitably for the inverter. The points of developments on inverter and power capacitor are described in this paper.his paper.