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RISS 인기검색어
- 검색키워드
- 저자 : Xudong Pan (검색결과 4 건)
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Pan Ming,Jun Lu,Xin Cai,Miaoyan Liu,Xudong Chen 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.7
In this study, the crack evolution process of crumb rubber concrete (CRC) in a four-point bending tensile test was monitored using the acoustic emission (AE) technique. The peak frequency, distribution characteristics of the AE source, and the damage process based on the AE ring count during the crack evolution were analyzed. The test results revealed that the addition of rubber particles decreased the brittleness of cracks and improved the ductility of the concrete during the macro-cracking process. The AE positioning method could effectively monitor the evolution process of micro-cracks inside the concrete. Additionally, based on the statistical results of the AE source events and energy distribution, the position of macroscopic cracks could be predicted, and the random distribution of micro-cracks could be characterized. By introducing the Weibull distribution to describe the random growth process of micro-cracks, the damage inside the concrete could be qualitatively predicted. As the rubber particle content increased, the inherent micro-cracks inside the concrete also increased. The damage inside the concrete was biased toward the crack nucleation stage.
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Yi Hu,Shinong Pan,Xudong Zhao,Wenli Guo,Ming He,Qiyong Guo 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.3
Objective: To evaluate orthopedic metal artifact reduction algorithm (O-MAR) in CT orthopedic metal artifact reduction at different tube voltages, identify an appropriate low tube voltage for clinical practice, and investigate its clinical application. Materials and Methods: The institutional ethical committee approved all the animal procedures. A stainless-steel plate and four screws were implanted into the femurs of three Japanese white rabbits. Preoperative CT was performed at 120 kVp without O-MAR reconstruction, and postoperative CT was performed at 80–140 kVp with O-MAR. Muscular CT attenuation, artifact index (AI) and signal-to-noise ratio (SNR) were compared between preoperative and postoperative images (unpaired t test), between paired O-MAR and non-O-MAR images (paired Student t test) and among different kVp settings (repeated measures ANOVA). Artifacts’ severity, muscular homogeneity, visibility of inter-muscular space and definition of bony structures were subjectively evaluated and compared (Wilcoxon rank-sum test). In the clinical study, 20 patients undertook CT scan at low kVp with O-MAR with informed consent. The diagnostic satisfaction of clinical images was subjectively assessed. Results: Animal experiments showed that the use of O-MAR resulted in accurate CT attenuation, lower AI, better SNR, and higher subjective scores (p < 0.010) at all tube voltages. O-MAR images at 100 kVp had almost the same AI and SNR as non-O-MAR images at 140 kVp. All O-MAR images were scored ≥ 3. In addition, 95% of clinical CT images performed at 100 kVp were considered satisfactory. Conclusion: O-MAR can effectively reduce orthopedic metal artifacts at different tube voltages, and facilitates low-tube-voltage CT for patients with orthopedic metal implants.
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Zhenyu Wu,Yong Shen,Zhongxiang Pan,Xudong Hu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7
This study aims to investigate the radial gradient structural effect on energy absorption and failure behavior ofbraided composite tubes. Two-layer tubular braided fabrics were fabricated using over-braiding technology with three typesof radial gradient configurations in terms of uninform, descending and ascending pattern. The structure of surface layertouching with indenter roll was found to have a significant role on the bending behavior and failure mode. The compositetube possessing the small angle surface layer tends to fail in top-surface mode characterized by compression damage incontact area between indenter roll and tube. With the increasing of the braiding angle in surface layer, the bottom-surfacefailure mode characterized by penetrating crack in circumferential direction was observed, which accompanies abruptlyloading drop and loss of energy absorption capacity. In addition, the tube in descending gradient pattern contributes to higherflexural modulus and peak load due to high fiber volume fraction, while keeps top-surface failure mode because of loadspreading ability provided by surface layer with small braiding angle. The results show that a proper selection of stackingsequence and braiding angle in multi-layer braided tube is capable of effectively enhancing the energy absorption of tubalstructures under bending load.
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Xia Wang,Hongqin Zhao,Shaonan Yang,Xiaojun Shao,Shumin Nie,Xudong Pan 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3
Backgrounds: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is an lncRNA that has been suggested as a key regulator in the onset of atherosclerosis (AS). This study described the role of MALAT1 in oxidized low density lipoprotein (ox-LDL)-induced endothelial cells death. Methods: Human umbilical vein endothelial cells (HUVECs) were subjected to ox-LDL, before which the expression of MALAT1 was overexpressed by transfection. CCK-8 assay, flow cytometer detection, and western blot were carried out to evaluate cell viability, apoptosis and autophagy. qRT-PCR and western blot analyses were performed to investigate the regulatory relationship between MALAT1, Matrix Gla protein (MGP) and mTOR signaling to decode the underlying mechanism. Results: Up-regulation of MALAT1 attenuated ox-LDLinduced HUVECs lose, as evidenced by the promoted cell viability, and the decreased apoptosis rate. This finding was coupled with the down-regulated p53, Bax, active-caspase-3, Beclin-1 and LC3-II, as well as the up-regulated Bcl-2 and p62. Meanwhile, MALAT1 upregulation promoted the phosphorylation of p70S6K and mTOR, and the expression of MGP. MGP up-regulation exhibited MALAT1-like propoties in preventing ox-LDL-induced cell death and mTOR deactivation. Of contrast, MGP silence affected HUVECs survival and mTOR signaling resulted in contrary impacts. Conclusion: The present work described that MALAT1 up-regulation prevented ox-LDL-mediated apoptosis and autophagy in HUVECs. The protective effects of MALAT1 might be partially via up-regulating MGP, which led to the activation of mTOR signaling.
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