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Shouying Li,Yangchen Deng,Xu Lei,Teng Wu,Zheng Qing Chen 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.2
The underlying mechanism of the wind-induced vibration of the hangers of the suspension bridges is still not fully understood at present and hence is comprehensively examined in this study. More specifically, a series of field measurements on the No. 2 hanger of the Xihoumen Bridge was first carefully conducted. Large amplitude vibrations of the hanger were found and the oscillation amplitude of the leeward cable was obviously larger than that of the windward cables. Furthermore, the trajectory of the leeward cable was close to an ellipse, which agreed well with the major characteristics of wake-induced vibration. Then, a theoretical model for the wake-induced vibration based on a 3-D continuous cable was established. To obtain the responses of the leeward cable, the finite difference method (FDM) was adopted to numerically solve the established motion equation. Finally, numerical simulations by using the structural parameters of the No. 2 hanger of the Xihoumen Bridge were carried out within the spatial range of 4≤X≤10 and 0≤Y≤4 with a uniform interval of ΔX=ΔY=0.25. The results obtained from numerical simulations agreed well with the main features obtained from the field observations on the Xihoumen Bridge. This observation indicates that the wake-induced vibration might be one of the reasons for the hanger oscillation of the suspension bridge. In addition, the effects of damping ratio and windward cable movement on the wake-induced vibration of the leeward cable were numerically investigated.
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RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
Tang Chao,Jin Meiyuan,Ma Bingbing,Cao Bin,Lin Chao,Xu Shouying,Li Jiayong,Xu Qiang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Production of estradiol (E2) by the placenta during human pregnancy ensures successful maintenance of placental development and fetal growth by stimulating trophoblast proliferation and the differentiation of cytotrophoblasts into syncytiotrophoblasts. Decreased levels of E2 are closely associated with obstetrical diseases such as preeclampsia (PE) in the clinic. However, the mechanisms underlying the inhibition of placental E2 biosynthesis remain poorly understood. Here, we report that regulator of G-protein signaling 2 (RGS2) affects E2 levels by regulating aromatase, a rate-limiting enzyme for E2 biosynthesis, by using human trophoblast-derived JEG-3 cells and human placental villus tissues. RGS2 enhanced the protein degradation of the transcription factor heart and neural crest derivatives expressed 1 (HAND1) by suppressing ubiquitin-specific protease 14 (USP14)-mediated deubiquitination of HAND1, resulting in the restoration of HAND1-induced trans-inactivation of the aromatase gene and subsequent increases in E2 levels. However, aromatase bound to RGS2 and repressed RGS2 GTPase activating protein (GAP) activity. Moreover, we observed a positive correlation between RGS2 and aromatase expression in clinical normal and preeclamptic placental tissues. Our results uncover a hitherto uncharacterized role of the RGS2-aromatase axis in the regulation of E2 production by human placental trophoblasts, which may pinpoint the molecular pathogenesis and highlight potential biomarkers for related obstetrical diseases.
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