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RISS 인기검색어
- 검색키워드
- 저자 : Xiaoyuan Hou (검색결과 3 건)
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NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest
Qiao Gu,Wenjie Hou,Huan Liu,Lijuan Shi,Zonghao Zhu,Wenfeng Ye,Xiaoyuan Ni 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.5
Purpose: Cervical cancer is one of the most fatal diseases among women in under-developed countries. To improve cervical cancer treatment, discovery of new targets is needed. In this study, we investigated the expression of NUP210, miR-22, and Fas in cervical cancer tissues and their functions in cell cycle regulation. Materials and Methods: We detected and compared the expression levels of NUP210, miR-22, and Fas in cervical cancer tissues with paired normal tissues using immunohistochemistry, Western blot, and real-time quantitative polymerase chain reaction. NUP210 was knocked down in HeLa cells via lentivirus, followed by cell cycle and proliferation analysis. Using a luciferase reporter assay, we explored the link between miR-22 and NUP210. We overexpressed miR-22 in HeLa cells and analyzed cell cycle and proliferation function. We then overexpressed miR-22 in NUP210 knockdown cells to explore the connection between Fas and miR-22-NUP210 signaling. Results: We found that NUP210 was overexpressed in cervical cancer patients. Knocking down NUP210 restored cell apoptosis and proliferation. We confirmed miR-22 as a regulator of NUP210 and verified that miR-22 was inhibited in cervical cancer development. We also found that restoring miR-22 expression could induce cell apoptosis. Finally, we found that miR-22-regulated expression of NUP210 could alter Fas expression and, in turn, elicit cell cycle arrest and proliferation. Conclusion: miR-22 in cervical cancer is downregulated, resulting in NUP210 overexpression and inhibition of Fas-induced cell apoptosis.
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Isophorone derivative as red dopant for organic electroluminescent devices
Huiying Fu,Huanrong Wu,Xiaoyuan Hou,Fei Xiao,Bingxian Shao 한국물리학회 2007 Current Applied Physics Vol.7 No.6
The donoracceptor functionalized molecule, bis(4-(2-(3,3-dicyanomethylene-5,5-dimethyl-1-cyclohexylidene)vinyl)phenyl)(1-naph-thyl)amine (DPN-4CN), with symmetrical structure, was investigated for its application in optoelectronic devices. Red organic light-emitting diodes (OLEDs) were fabricated by doping DPN-4CN in tris(8-hydroxyquinolino) aluminum (Alq3) as red emitters, with astructure of ITO/NPB/Alq3:DPN-4CN/BCP/Alq3/LiF/Al. The device with a doping concentration of 2.5 wt% showed pure red emissionwithkmax . 2 at a driving voltage of 12 V, a current eciencyof 2.14 cd A. 1 and an external quantum eciency of 1.07% at a current density of 20 mA cm. 2. The current eciencies and CIE coor-dinates of the device were almost constant over a current density from 1 to 200 mA cm. 2.
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Zijun Xiao,Xiankun Zhu,Lijun Xi,Xiaoyuan Hou,Li Fang,Jian R. Lu 한국미생물학회 2014 The journal of microbiology Vol.52 No.5
In the effluents of a biologically treated wastewater from aheavy oil-refining plant, C5-C8 fatty acids including pentanoicacid, hexanoic acid, heptanoic acid, octanoic acid, and2-methylbutanoic acid are often detected. As these residualfatty acids can cause further air and water pollution, a newMyroides isolate ZB35 from activated sludge was explored todegrade these C5-C8 fatty acids in this study. It was foundthat the biodegradation process involved a lag phase thatbecame prolonged with increasing acyl chain length whenthe fatty acids were individually fed to this strain. However,when fed as a mixture, the ones with longer acyl chains werefound to become more quickly assimilated. The branched 2-methylbutanoic acid was always the last one to be depletedamong the five fatty acids under both conditions. Metaboliteanalysis revealed one possible origin of short chain fatty acidsin the biologically treated wastewater. Aroma volatiles including2-methylbutyl isovalerate, isoamyl 2-methylbutanoate,isoamyl isovalerate, and 2-methylbutyl 2-methylbutanoatewere subsequently identified from ZB35 extracts, linking thesource of the fruity odor to these esters excreted by Myroidesspecies. To our best knowledge, this is the first finding of thesearoma esters in bacteria. From a biotechnological viewpoint,this study has revealed the potential of Myroides species asa promising source of aroma esters attractive for food andfragrance industries.
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