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RISS 인기검색어
- 검색키워드
- 저자 : Xiaoyu Shang (검색결과 3 건)
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Tan Xiaoyue,Sun Xiaolin,Chen Yang,Wang Fanghu,Shang Yuxiang,Zhang Qing,Yuan Hui,Jiang Lei 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.3
Objective: We previously found that the incidence of sarcopenia increased with declining glucose metabolism of muscle in patients with treatment-naïve diffuse large B-cell lymphoma (DLBCL). This study aimed to investigate the relationship between sarcopenia and muscle glucometabolism using 18F-FDG PET/CT at baseline and end-of-treatment, analyze the changes in these parameters through treatment, and assess their prognostic values. Materials and Methods: The records of 103 patients with DLBCL (median 54 years [range, 21–76]; male:female, 50:53) were retrospectively reviewed. Skeletal muscle area at the third lumbar vertebral (L3) level was measured, and skeletal muscle index (SMI) was calculated to determine sarcopenia, defined as SMI < 44.77 cm2/m2 and < 32.50 cm2/m2 for male and female, respectively. Glucometabolic parameters of the psoas major muscle, including maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean), were measured at L3 as well. Their changes across treatment were also calculated as ΔSMI, ΔSUVmax, and ΔSUVmean; Δbody mass index was also calculated. Associations between SMI and the metabolic parameters were analyzed, and their associations with progression-free survival (PFS) and overall survival (OS) were identified. Results: The incidence of sarcopenia was 29.1% and 36.9% before and after treatment, respectively. SMI (P = 0.004) was lower, and sarcopenia was more frequent (P = 0.011) at end-of-treatment than at baseline. The SUVmax and SUVmean of muscle were lower (P < 0.001) in sarcopenia than in non-sarcopenia at both baseline and end-of-treatment. ΔSMI was positively correlated with ΔSUVmax of muscle (P = 0.022). Multivariable Cox regression analysis showed that sarcopenia at end-of-treatment was independently negatively associated with PFS (adjusted hazard ratio [95% confidence interval], 2.469 [1.022–5.965]), while sarcopenia at baseline was independently negatively associated with OS (5.051 [1.453–17.562]). Conclusion: Sarcopenic patients had lower muscle glucometabolism, and the muscular and metabolic changes across treatment were positively correlated. Sarcopenia at baseline and end-of-treatment was negatively associated with the prognosis of DLBCL.
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Cyclic Behavior of Steel Frame Joints in the Offshore Atmospheric Environment
Qiang Xu,Xiaoyu Shang,Shansuo Zheng 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3
The natural deterioration of mild steel elements exposed to off shore atmospheric environments compromises the long-term safety of existing steel buildings. An experimental study was conducted to investigate the eff ect of the off shore atmospheric environment on the seismic performance of steel frame joints. An indoor accelerated corrosion test was conducted to simulate the degradation of the mechanical properties of the materials and steel frame joints in the off shore atmospheric environment. After determining the corrosion rate by weighing after rust removal, the yield strength, ultimate strength, modulus of elasticity, and elongation of three test specimen with diff erent thicknesses were obtained by regression of the tensile failure test, which demonstrated a linear decay relationship with the corrosion rate. Under four diff erent corrosion degrees and three diff erent low-cycle reciprocating loads, the failure modes of 12 steel frame joints were all plate-tearing at welded through holes. However, the diff erence is that the joints had ductile failure under equal-amplitude 90 mm loading and brittle failure under variable-amplitude loading. The eff ects of corrosion on the hysteresis behavior, deformation degradation, strength degradation, and energy dissipation capacity of steel frame joints were analyzed. The test results indicate that corrosion has signifi cant eff ects on the seismic performance of steel frame joints. With the increase in corrosion degree, the energy dissipation capacity of steel frame joints declines more signifi cantly than other performance indicators, and the yield platform of the steel frame joints is not evident.
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Li Ping,Chang Xuelian,Chen Xiaoyu,Tang Tiantian,Liu Yajing,Shang Yu,Qi Kemin 한국미생물학회 2022 The journal of microbiology Vol.60 No.8
The maturation of infant gut microbiota has lifelong implications on health, which has been proposed as the major events during the first year of life. However, little is known about their dynamic colonization and influencing elements among the first two-year infancy as well as into the adulthood. So based on the 16S rRNA sequencing data among 30 healthy breast-feeding mother-infant pairs with normal ranges of growth and development indicators from birth to two years old, the dynamic colonization of gut microbiota and its influencing factors were discussed using this birth cohort. Among these, we identified that the diversity of gut microbiota was significantly increased from six-month to two-year subgroups. The significantly dynamic trends of gut microbiota at the phylum (genus) level were that the percents of Firmicutes (Faecalibacterium, Blautia, Enterococcus, Subdoligranulum, Agathobacter, unidentified_Erysipelotrichaceae, Staphylococcus, unidentified_Ruminococcaceae, and Fusicatenibacter), Bacteroidetes and Verrucomicrobia were increased, while Actinobacteria (Bifidobacterium) and Proteobacteria (unidentified- Enterobacteriaceae and Klebsiella) were decreased with the increased ages from six months to two years old, which might simultaneously modulate the host pathways, such as the higher percents of chemoheterotrophy and fermentation, and lower percentages of nitrate_reduction, aerobic_chemoheterotrophy and so on. Furthermore, there were significant associations between maternal (milk microbiota, pre-pregnancy BMI, BMI increment during the pregnancy)/infant characteristics (BMI at birth and BMI gain), and the compositions of gut microbiota. However, no differences of gut microbiota were shown between the different sex and productive mode subgroups. Overall, the colonization of gut microbiota is significantly matured into the adulthood with the increased ages to two-years old and regulated by the above maternal/infant characteristics, which will provide a new direction for the host-gut microbiota interplay during the first two years of life.
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