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Small-conductance Ca2+-activated K+ channels: insights into their roles in cardiovascular disease
Mingxia Gu,Yanrong Zhu,Xiaorong Yin,Dai-Min Zhang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocytes. Action potential formation results from the opening and closing of ion channels. Recent studies have indicated that small-conductance calcium-activated potassium (SK) channels play a critical role in cardiac repolarization in pathophysiological but not normal physiological conditions. The aim of this review is to describe the role of SK channels in healthy and diseased hearts, to suggest cardiovascular pathophysiologic targets for intervention, and to discuss studies of agents that target SK channels for the treatment of cardiovascular diseases.
Effect of Ni2Si Precipitates on Microstructure and Mechanical Properties of Cu–Zn Brasses
Wei Chen,Kai You,Jufang Yin,Ming Chen,Xiaolan Tao,Jiarui Hu,Xiaorong Chen,Qian Lei 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.10
Novel ultrahigh strength Ni2Sistrengthened brasses were fabricated, and microstructure and properties were investigatedusing scanning electron microscopy, optical microscopy, transmission electron microscopy, X-ray diffraction analysis, hardnessmeasurement, and electrical conductivity test. After optimal treatments (solid solution treated at 900 ℃ for 2 h, hotrolledby 80%, cold-rolled by 80%, and ageing treated at 300 ℃ for 8 h), the Cu-20Zn-3Ni-0.68Si alloy’s hardness, tensilestrength, yield strength, and electrical conductivity is 270.6 HV, 964 MPa, 933 MPa, 21.6%IACS, and 3.4%, respectively. δ-Ni2Si precipitates formed during the annealing process, which had a crystal orientation relationship with the matrix: (001)m// (001) δ, and [110]m// [100]δ. Quasi-cleavage fracture surfaces with shallow dimples were presented in both the Cu-20Zn-1.5Ni-0.34Si and the Cu-20Zn-3Ni-0.68Si alloy. These findings give a new method to develop new high strength low-costbrass copper materials.