Synthesis and Cytotoxicity Evaluation of New 3-substituted 4-(4-methyloxy phenyl)-1H-Pyrrole Derivatives

Xiaoping Zhan,Lan Lan,Yuankui Zhang,Jian Chen,Kai Zhao,Shuai Wang,Yuxuan Xin,Zhenmin Mao 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.2

A new series of 3-substituted 4-(4-methyloxy phenyl)-1H-pyrrole derivatives were synthesized and biologically evaluated for potential anticancer activity. Fifteen targeted compounds showed high selectivity toward normal cells and cancer cells: that is, all targeted compounds had no obvious cytotoxicity toward normal human cells (HUVEC and NIH/3T3), but some compounds exhibited broad-spectrum proliferation inhibitory activity against the screened cancer cell lines. Among these pyrrole derivatives, compounds 3b and 3o showed potent anticancer activity against the MG-63 cell line, with IC50 values of 14.9 and 12.7 μM, respectively. Other pyrrole derivatives also showed promising proliferation inhibitory activity, including compound 3d against A375 (IC50 = 18.6 μM), compound 3f and 3j against MGC80-3 (IC50 = 19.9 μM), and compound 3o against MGC80-3 (IC50 = 11.9 μM). Because the developed pyrrole derivatives showed strong anticancer activity and high selectivity, this new series of pyrrole derivatives could be considered as promising lead compounds for further development of potent and safe anticancer agents.

Bartonella rochalimae, B. grahamii, B. elizabethae, and Wolbachia spp. in Fleas from Wild Rodents near the China-Kazakhstan Border

Xiaoping Yin,Shanshan Zhao,Bin Yan,Yanhe Tian,Teer Ba,Jiangguo Zhang,Yuanzhi Wang 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.5

The Alataw Pass, near the Ebinur Lake Wetland (northwest of China) and Taldykorgan (east of Kazakhstan), is a natural habitat for wild rodents. To date, little has been done on the surveillance of Bartonella spp. and Wolbachia spp. from fleas in the region. Here we molecularly detected Bartonella spp. and Wolbachia spp. in wild rodent fleas during January and October of 2016 along the Alataw Pass-Kazakhstan border. A total of 1,706 fleas belonging to 10 species were collected from 6 rodent species. Among the 10 flea species, 4 were found to be positive for Wolbachia, and 5 flea species were positive for Bartonella. Molecular analysis indicated that i) B. rochalimae was firstly identified in Xenopsylla gerbilli minax and X. conforms conforms, ii) B. grahamii was firstly identified in X. gerbilli minax, and iii) B. elizabethae was firstly detected in Coptopsylla lamellifer ardua, Paradoxopsyllus repandus, and Nosopsyllus laeviceps laeviceps. Additionally, 3 Wolbachia endosymbionts were firstly found in X. gerbilli minax, X. conforms conforms, P. repandus, and N. laeviceps laeviceps. BLASTn analysis indicated 3 Bartonella species showed genotypic variation. Phylogenetic analysis revealed 3 Wolbachia endosymbionts were clustered into the non-Siphonaptera Wolbachia group. These findings extend our knowledge of the geographical distribution and carriers of B. rochalimae, B. grahamii, B. elizabethae, and Wolbachia spp. In the future, there is a need for China-Kazakhstan cooperation to strengthen the surveillance of flea-borne pathogens in wildlife.

RECTIFIABILITY PROPERTIES OF VARIFOLDS IN l³_∞

Zhao, Peibiao,Yang, Xiaoping Korean Mathematical Society 2007 대한수학회보 Vol.44 No.1

We prove the following theorem: Given a Varifold V in $l^{3}_{\infty}$ with the property that 0 < $lim_{r}_{\rightarrow}_{o}\;\frac{{\mu}v(C_{r}(x))}{r^{2}}\;<\;{\infty}\;for\;{\mu}v\;a.e.x\;{\in}$ SptV, then V is rectifiable.

Transcriptome-Wide Analyses Provide Insights into Development of the Hedychium coronarium Flower, Revealing Potential Roles of PTL

Zhao Tong,Piñeyro-Nelson Alma,Yu Qianxia,Pan Xiaoping,Hu Xiaoying,Liu Huanfang,Liao Jingping 한국식물학회 2021 Journal of Plant Biology Vol.64 No.5

The flower of Hedychium coronarium possesses highly specialized floral organs: a synsepalous calyx, petaloid staminodes and a labellum. The formation of these organs is controlled by two gene categories: floral organ identity genes and organ boundary genes, which may function individually or jointly during flower development. Although the floral organogenesis of H. coronarium has been studied at the morphological level, the underlying molecular mechanisms involved in particular organ morphologies that emerge in flower development still remain poorly understood. Here, we used comparative transcriptomics combined with Real-time quantitative PCR to investigate gene expression patterns of ABC-class genes in H. coronarium flowers, as well as the homolog of PETAL LOSS (HcPTL). Our studies found that stamen/petal identity or stamen fertility in H. coronarium was not necessarily correlated with the differential expression of HcAP3 and HcAG. We also found a novel spatio-temporal expression pattern for HcPTL mRNA, suggesting it may have evolved a lineage-specific role in the morphogenesis of the Hedychium flower. Our study provides a new transcriptome reference and a functional hypothesis regarding the role of a boundary gene in organ fusion that should be further addressed through phylogenetic analyzes of this gene, as well as functional studies.

Rectifiability properties of Varifolds in $l^{3}_{\infty}$

Peibiao Zhao,Xiaoping Yang 대한수학회 2007 대한수학회보 Vol.44 No.1

Preparation and Performance Study of Self-Cleaning TiO2/Kaolin-Finished Cotton Fabric

Qiang Zhao,Yunting Zhang,Zhenjiang Liu,Huiyan Ma,Yan Li,Xiaoping Gao 한국섬유공학회 2023 Fibers and polymers Vol.24 No.12

TiO2/kaolin was first synthesized by using ultrasound-sol–gel method and then deposited onto the surface of cotton fabrics through two dipping and two rolling process. To investigate the properties of this TiO2/kaolin-finished cotton fabric, TiO2/kaolin/cotton composites were characterized by Fourier transform infrared spectrum and energy dispersive spectrometer, while the surface morphologies of the cotton fabrics were analyzed by field emission scanning electron microscopy. The whiteness, air permeability, breaking strength and elongation of TiO2/kaolin/cotton composites were, respectively, measured and the results showed that all these parameters decreased slightly with the appearance of TiO2/kaolin. The UPF value of TiO2/kaolin/cotton composites was significantly enhanced to 100+ , even if after soaping for 30 times, which might be due to the synergistic effect of kaolin and TiO2. In addition, the performance such as hand feel attributes, softness, smoothness and stiffness were measured by PhabrOmeter, respectively. The stiffness of all finished fabrics was obviously better than that of the unfinished cotton. However, the softness and smoothness of finished fabrics were slightly decreased compared to unfinished cotton. Rhodamine B was used as a test contaminant to qualitatively assess the self-cleaning properties of the TiO2/kaolin-finished cotton fabric. The removal of Rhodamine B indicated that the TiO2/kaolin-finished fabric exhibited excellent photocatalytic properties. This study illustrates the great potential of the low-cost kaolin powder as an efficient finishing agent for the fabric finishing process, and meanwhile provides a novel suggestion for fabric modification.

Investigation on characteristics of pulverized coal dense-phase pneumatic conveying under high pressure

Chen Xiaoping,Fan Chunlei,Liang Cai,Pu Wenhao,Lu Peng,Zhao Changsui 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.3

of dense-phase pneumatic conveying of pulverized coal were carried out in a test facility witha conveying pressure up to 4 MPa. The influence of fluidization nitrogen flow rate, the flow rate of supplementarysolid mass flow rate was investigated. Test results indicate that with the increase in fluidization nitrogen flow rate, thesolid mass flow rate increases, and the solids to gas ratio increases at first and then declines. When the fluidization ofpulverized coal in the sending vessel becomes intensive, with the increase in supplementary nitrogen flow rate, thesolids to gas ratio declines and the solid mas flow rate increases. And the solid mass flow rate increases linearly withthe increase in presure diference between two hoppers. The experimental results provide a database for the design

Low‐Voltage Pulsed Electric Field Sterilization on a Microfluidic Chip

Liu, Linlin,Zhao, Liping,Yang, Jun,Wan, Xiaoping,Hu, Ning,Yeh, Li‐,Hsien,Joo, Sang W.,Qian, Shizhi WILEY‐VCH Verlag 2013 Electroanalysis Vol.25 No.5

<P><B>Abstract</B></P><P>A polyimide substrate based microfluidic chip with thousands of comb‐shaped microelectrodes has been designed, fabricated, and tested for sterilization of bacteria by using pulsed electric field. The performance of bacteria sterilization as functions of the electric field strength, pulse number and width, treatment buffer, bacteria growth status, and bacteria enrichment by positive dielectrophoresis has been experimentally investigated on the microfluidic chip. Experimental results show that only 100 V are sufficient to obtain good sterilization of <I>Escherichia coli</I>. Higher electric field strength, bacteria enrichment by positive dielectrophoresis, longer pulse time, buffer with fewer components and nutritions, and suitable bacteria growth status also improve the sterilization of bacteria. In addition, configuration of the microelectrode array affects bacteria sterilization. This microfluidic device allows one to preconcentrate bacteria to a region with high electric field strength by using positive dielectrophoresis, and subsequently kill the enriched bacteria by applying a pulsed electric field through the same microelectrode array.</P>

Grain Morphology and Orientation Effect on the High‑Temperature Tensile Behavior of Directionally Solidified Magnesium Alloy

Qin Tang,Xiaoping Lin,Shengshi Zhao,Yi Niu,Heng Sun,Yun Dong 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.4

Columnar-structured Mg97.27Zn2.54Y0.19alloy with the preferred growth direction of ⟨22̄45⟩ and ⟨12̄33⟩, andMg98.01Zn1.84Y0.13Zr0.03alloy with the preferred growth direction of ⟨11̄20⟩ were prepared using the directional solidificationtechnique and then tensile tested at 250–300 °C. The results showed that the Mg97.27Zn2.54Y0.19alloy with columnar dendriticstructure experienced a significant deformation strengthening period when stretched at 250 °C, and a typical dynamicrecrystallization stage at 300 °C, which were mainly accounted for its well-developed secondary dendrites, a large numberof branch-shaped second phases distributed in the longitudinal grain boundary, and less granular second phases existingin the crystal. While in the whole test temperature range (250–300 °C), the stress–strain curves of Mg98.01Zn1.84Y0.13Zr0.03alloys with cellular dendritic crystals showed a steady deformation state because of the second phases with strip distributingin the longitudinal grain boundary, which was induced by a balance between the deformation strengthening and the dynamicrecrystallization. Especially at 300 °C, this steady deformation state existed in the strain of 5.6%–36%. The good uniformplastic deformation was closely related to the small misorientations between columnar grains, the associated movement ofgrains by grain boundary slipping, and the less percentage of dynamically recrystallized grains which could do harm to theorientation continuity of the columnar crystals.

Research on Influence of Matrix Component on the Mechanical Behavior of Multiaxial Warp-knitted Composites

Jiawei Chen,Xiaoping Gao,Ke Zhao,Wei Wu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11

The mass ratio of curing agent to epoxy resin is one of the important factors affecting the behavior of matrix andcomposites. In this paper, the solution of curing agent to epoxy resin with different mass ratio (0.25, 0.30, 0.35 and 0.40) wasselected as matrix, quadriaxial warp-knitted fabric was selected as reinforcement, and the composites were manufactured byapplying vacuum assisted film infusion. Then the tensile and bending behavior of the composites was experimentallyinvestigated, and the curing degree and failure mechanism of the composites were analyzed with respect to thethermodynamic properties and the microscopic failure morphologies. The optimal mass ratio was obtained by applyingnonlinear fitting and verified by experiment, and a mathematical model was derived to predict the relationship between thestrength and the mass ratio. The results showed that the thermal stability, curing degree, tensile and bending strength of thespecimens increase firstly and then decrease with increase of the mass ratio. According to the tensile and bending strengthresults, the optimum mass ratio were obtained as 0.31 and 0.33 by applying nonlinear fitting to the experiment data. Theresults could lay a theoretical foundation for optimizing the mass ratio of matrix components, and improve the strength ofcomposites.