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- 저자 : Xiaofan Fei (검색결과 3 건)
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Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.
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Self-adjusting strategy based on rotating injection for sensorless control of high-power PMSM drives
Xiaofan Wang,Xiaochun Fang,Zhi Wang,Zhihong Zhong,Yizhi Wang,Fei Lin,Zhongping Yang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
As a sensorless control method suitable for permanent magnet synchronous motor (PMSM) at lowspeed, rotating high-frequency injection method will face some special problems in high power applications. On the one hand, the low switching frequency limits the injected signal frequency, which is very close to the fundamental frequency. On the other hand, under heavy load conditions, the fundamental current amplitude is several hundred times of the negative sequence current. This will result in difficulty in signal extraction. In this paper, current spectrum is analyzed quantitatively based on the parameters of PMSM drive for rail vehicles, which illustrates the limitations of conventional bandpass filters. A method based on self-adjusting filter is proposed. The negative sequence current is successfully extracted, and the precise rotor position is obtained under the condition of variable speed and variable load. Based on a fullscale test platform the effectiveness of the proposed method is proved.
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Qian He,Xiaohua Chen,Tang Wu,Liyuan Li,Xiaofan Fei 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1
Background and Purpose There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the long-term usage of BDZs and the risk of dementia. Methods The PubMed and Embase databases were systematically searched for relevant publications up to September 2017. The literature search focused on observational studies that analyzed the relationship between the long-term use of BDZs and the risk of dementia. Pooled rate ratios (RRs) with 95% confidence interval (CI) were assessed using a random-effects model. The robustness of the results was checked by performing subgroup and sensitivity analyses. Results Ten studies were included: six case–control and four cohort studies. The pooled RR for developing dementia was 1.51 (95% CI=1.17–1.95, p=0.002) in patients taking BDZ. The risk of dementia was higher in patients taking BDZs with a longer half-life (RR=1.16, 95% CI= 0.95–1.41, p=0.150) and for a longer time (RR=1.21, 95% CI=1.04–1.40, p=0.016). Conclusions This meta-analysis that pooled ten studies has shown that BDZ significantly increases the risk of dementia in the elderly population. The risk is higher in patients taking BDZ with a longer half-life (>20 hours) and for a longer duration (>3 years).
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