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        Microflame diffusion properties of AP/HTPB propellant under binder width effects

        Kaixuan Chen,Xiaochun Xue,Yonggang Yu,Zhenwei Ye 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.2

        The present study proposes a method to estimate the microflame properties of ammonium perchlorate/hydroxyl-terminated polybutadiene (AP/HTPB) propellant at different binder widths. A 3D random particle packing is generated by the Monte Carlo method. A transformation from Miller packing to sandwich model is used by the dual slicing technique. The gassolid coupling model and the two-step BDP flame model in the combustion field are established to study the influence of kinetic chemical and fluid diffusion process on the micrflame properties. Finally, the mathematical relationships of the burning rate br and the final flame height H 3on the HTPB thickness D are obtained by analyzing and fitting combustion processes of multiple AP/HTPB propellants, namely, b+1.22D 2 -13.07D+67.73.

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        Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring

        Ting Jin,Ranran Wang,Shiqiao Peng,Xin Liu,Hanyi Zhang,Xue He,Weiping Teng,Xiaochun Teng 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.2

        Background: Developmental hypothyroidism impairs learning and memory in offspring, which depend on extensive neuronal circuits in the entorhinal cortex, together with the hippocampus and neocortex. The entorhinal-dentate gyrus pathway is the main entrance of memory circuits. We investigated whether developmental hypothyroidism impaired the morphological development of theentorhinal-dentate gyrus pathway. Methods: We examined the structure and function of the entorhinal-dentate gyrus pathway in response to developmental hypothyroidism induced using 2-mercapto-1-methylimidazole. Results: 1,1´-Dioctadecyl-3,3,3´,3´-tetramethylindocarbocyanine perchlorate tract tracing indicated that entorhinal axons showeddelayed growth in reaching the outer molecular layer of the dentate gyrus at postnatal days 2 and 4 in hypothyroid conditions. Theproportion of fibers in the outer molecular layer was significantly smaller in the hypothyroid group than in the euthyroid group atpostnatal day 4. At postnatal day 10, the pathway showed a layer-specific distribution in the outer molecular layer, similar to the euthyroid group. However, the projected area of entorhinal axons was smaller in the hypothyroid group than in the euthyroid group. Anelectrophysiological examination showed that hypothyroidism impaired the long-term potentiation of the perforant and the cornuammonis 3–cornu ammonis 1 pathways. Many repulsive axon guidance molecules were involved in the formation of the entorhinaldentate gyrus pathway. The hypothyroid group had higher levels of erythropoietin-producing hepatocyte ligand A3 and semaphorin3A than the euthyroid group. Conclusion: We demonstrated that developmental hypothyroidism might influence the development of the entorhinal-dentate gyruspathway, contributing to impaired long-term potentiation. These findings improve our understanding of neural mechanisms formemory function.

      • KCI등재

        The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study

        Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2

        This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.

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