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Wang Jianle,Xia Dongdong,Lin Yan,Xu Wenbin,Wu Yaosen,Chen Jiaoxiang,Chu Junjie,Shen Panyang,Weng Sheji,Wang Xiangyang,Shen Lifeng,Fan Shunwu,Shen Shuying 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Low back pain, triggered by intervertebral disc degeneration (IVDD), is one of the most common causes of disability and financial expenditure worldwide. However, except for surgical interventions, effective medical treatment to prevent the progression of IVDD is lacking. This study aimed to investigate the effects of circKIF18A, a novel circRNA, on IVDD progression and to explore its underlying mechanism in IVDD. In this study, we found that oxidative stress was positively correlated with nucleus pulposus cell (NPC) senescence in IVDD and that circKIF18A was downregulated in IVDD and attenuated senescent phenotypes such as cell cycle arrest and extracellular matrix degradation in NPCs. Mechanistically, circKIF18A competitively suppressed ubiquitin-mediated proteasomal degradation of MCM7, and the protective effects of circKIF18A on NPCs were partially mediated by MCM7 under oxidative stress. Intradiscal injection of adenoviral circKIF18A ameliorated IVDD in a rat model. This study revealed that circKIF18A regulates NPC degeneration by stabilizing MCM7 and identified a novel signaling pathway, the circKIF18A-MCM7 axis, for anti-senescence molecular therapy in IVDD.
Effect of Short-Time Carburizing Treatment on Microstructure and Mechanical Properties of M50 Steel
Yinghua Wei,Xingfu Yu,Shuai Wang,Xiangyang Shen,Wenzeng Zhao,Yong Su,Yu Yang,Xiaochuan Feng 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.6
By using scanning electron microscope (SEM), transmission electron microscope (TEM), X-Ray diffraction (XRD), and hardnessand rotational bending fatigue tests, the effect of short-time carburizing treatment on the microstructure and mechanicalproperties of bearing steel was studied. The results show that when the M50 steel is not carburized, the hardness is 750 HV,the rotational bending fatigue limit is 1100 MPa, and the impact absorption energy is 15.46 J. After short-time carburizationwith the carbon potential of 0.6%, the maximum hardness in the carburized area, the rotational bending fatigue limitand the impact absorption energy are all increased to be 807.7 HV, 1210 MPa and 16.72 J respectively. When the carbonpotential is further enhanced to be 0.8%, the maximum hardness of the carburized area of the steel is further enhanced to be813.4 HV, but the rotational bending fatigue strength and the impact absorption energy are both decreased to be 1125 MPaand 13.65 J respectively, which has close relations with the increasement of undissolved carbides and the precipitation ofacicular carbides.