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Amplitude dependency of damping of tall structures by the random decrement technique
An Xu,Zhuangning Xie,Ming Gu,Jiurong Wu 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.2
This study focuses on the amplitude dependency of damping of tall structures by the random decrement technique (RDT). Many researchers have adopted RDT to establish the amplitude dependency of damping ratios in super-tall buildings under strong wind loads. In this study, a series of simulated examples were analyzed to examine the reliability of this method. Results show that damping ratios increase as vibration amplitudes increase in several cases; however, the damping ratios in the simulated signals were preset as constants. This finding reveals that this method and the derived amplitude-dependent damping ratio characteristics are unreliable. Moreover, this method would obviously yield misleading results if the simulated signals contain Gaussian white noise. Full-scale measurements on a super-tall building were conducted during four typhoons, and the recorded data were analyzed to observe the amplitude dependency of damping ratio. Relatively wide scatter is observed in the resulting damping ratios, and the damping ratios do not appear to have an obvious nonlinear relationship with vibration amplitude. Numerical simulation and field measurement results indicate that the widely-used method for establishing the amplitude-dependent damping characteristics of super-tall buildings and the conclusions derived from it might be questionable at the least. More field-measured data must be collected under strong wind loads, and the damping characteristics of super-tall buildings should be investigated further.
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Wavelet-transform-based damping identification of a super-tall building under strong wind loads
An Xu,Jiurong Wu,Ruohong Zhao 한국풍공학회 2014 Wind and Structures, An International Journal (WAS Vol.19 No.4
A new method is proposed in this study for estimating the damping ratio of a super tall building under strong wind loads with short-time measured acceleration signals. This method incorporates two main steps. Firstly, the power spectral density of wind-induced acceleration response is obtained by the wavelet transform, then the dynamic characteristics including the natural frequency and damping ratio for the first vibration mode are estimated by a nonlinear regression analysis on the power spectral density. A numerical simulation illustrated that the damping ratios identified by the wavelet spectrum are superior in precision and stability to those values obtained from Welch’s periodogram spectrum. To verify the efficiency of the proposed method, wind-induced acceleration responses of the Guangzhou West Tower (GZWT) measured in the field during Typhoon Usagi, which affected this building on September 22, 2013, were used. The damping ratios identified varied from 0.38% to 0.61% in direction 1 and from 0.22% to 0.59% in direction 2. This information is expected to be of considerable interest and practical use for engineers and researchers involved in the wind-resistant design of super-tall buildings.
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Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4
Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.
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임서무 ( Xu Wu Lin ) 東亞大學校附設 石堂傳統文化硏究院 2011 石堂論叢 Vol.0 No.51
항전시기 오정창은 귀주성 정부 주석직을 7년간 맡아 보면서 다양한 정책을 통해 귀주의 발전을 촉진하였다. 위생 보건, 금연, 군사훈련, 그리고 체육 등의 분야에 많은 노력을 기울였으며, 인구의 증가와 의식 수준의 향상을 위해 노력하였다. 농업과 임업 목축업과 양잠업, 전기 및 광공업, 교통과 운수 등의 사업을 통해 귀주기업주식회사를 설하여 공업화의 길을 모색하였다. 현장(縣長)의 선발 과정과 조직 정비, 현 정부와 향진 간의 권리와 책임을 구분하여 기층의 민주 정치를 발전시켰다. 이러한 시책은 남경 국민정부의 통치를 옹호하는 것이었으며, 또한 귀주의 현대화를 추진함으로써 후방을 튼튼히 하여 항전의 승리에 일정 정도 공헌함으로써 새로운 정치학 체계의 정치적 주장과 역사적 가치를 잘 보여주고 있다. Wu Ding-chang had been undertaken the government chairman in Guizhou province for seven years during the Anti-Japanese War. He took some policies of sanitation, anti-smoking, military training and physical education to increase the population. At the same time, he also used methods of school education and administration training to enhance population`s quality. And he initiated a new path of industrialization by developing agriculture, forestry, animal husbandry, raising silk worms, electricity, industry, mining and transportation and setting up Guizhou enterprise stock corporation. Moreover, he improved the methods of choosing the head of a county and ranks building, divided the rights and responsibilities between county and small towns and developed skeleton democratic politics. These policies impelled the economic and social modernization in Guizhou and made great contributions for consolidating Kuomintang-controlled areas and supporting the victory during the Anti-Japanese War.
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Wu, Hongzhi,Sun, Hao,Ma, Chengzhan,Lian, Lina,Lu, Lei,Xu, Liangmei,Xu, Li Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.11
Objective: The effects of maternal dietary energy levels on breast muscle fibre development in offspring of broiler breeders were investigated. Methods: A total of 480 20-week-old Arbor Acres (AA) healthy female broiler breeders, with an average body weight of 2.33±0.01 kg, were randomly divided into 4 treatment groups with 6 replicates and 20 broiler breeders for each replicate and fed a corn and soybean meal diet with 100%, 80%, 70%, and 50% energy levels, respectively. Approximately 300 eggs per treatment were collected for incubation for 6 days. Then, 120 0-day-old female broilers at each energy level were randomly selected and divided into 6 replicates with 20 broilers for each replicate, with this experimental phase with the offspring lasting for 49 days. Results: Compared with the 100% energy group, the breast muscle fibre diameter at embryonic day 21 in the 80% energy group was significantly reduced (p<0.05). In the 80% energy group, the muscle fibre density of the breast increased significantly (p<0.05) at embryonic days 15 and 21. The breast muscle fibre diameter of the offspring in each group was significantly decreased (p<0.05) on the 1st day. The breast muscle sarcomere length of the embryos in the 80% energy group was significantly higher (p<0.05) than those in the 70% and 50% energy groups. Compared with the 100% energy group, the expression of the myostatin gene in the offspring was significantly decreased (p<0.05). Conclusion: In conclusion, the effects of a maternal dietary energy level of 80% in this study were found to be optimal for breast muscle fibre development in offspring, which indicated that the metabolic energy level of AA broilers of 9.36 MJ/kg for the mid-term diet for laying eggs has a more practical significance.
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Legumain Protein as a Potential Predictive Biomarker for Asian Patients with Breast Carcinoma
Wu, Mei,Shao, Guang-Rui,Zhang, Fei-Xue,Wu, Wen-Xiu,Xu, Ping,Ruan, Zheng-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: Treatment for breast cancer is mainly performed by surgical resection of primary tumors and chemotherapy. However, after tumor invasion and metastases, breast cancer is hard to control. Clarification of the pathogenic mechanisms would be helpful to the prognosis or therapy for the breast cancer. The aim of this study is to investigate the clinical and prognostic implications of legumain protein Materials and Methods: In this study, we examined mastectomy specimens from 114 breast cancer and matching, 26 adjacent non-cancerous tissues using immunohistochemistry. Results: The results indicated that positive expression of legumain protein in breast cancer was 51.8 % (59/114) and the positive expression of legumain protein in adjacent non-cancerous tissue was 11.5% (3/26). It appeared to be related with lymph node metastasis of breast cancer (p=0.02) and correlation analysis indicated that legumain expression was correlated positively with the estrogen receptor (ER) and mutant-type p53 expression (both p<0.05). Positive legumain expression was significantly associated with shorter overall survival time in breast cancer patients (log-rank p<0.01). Multivariate survival analysis suggested that the positive legumain expression was an independent predictor of poorer overall survival in patients with breast cancer (HR=0.24; 95%CI 0.11-0.65, p=0.03). Conclusions: Legumain might be a new potential biomarker for breast cancer, which may reflect the prognosis and overall survival.
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Xu, Lu-Wei,Qian, Ming,Jia, Rui-Peng,Xu, Zheng,Wu, Jian-Ping,Li, Wen-Cheng,Huang, Wen-Bin,Chen, Xing-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
The aim of this study was to investigate the expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer (PCa). Immunohistochemistry was performed on paraffin-embedded sections with rabbit polyclonal against mPGES-1 and Beclin-1 in 40 PCa, 40 benign prostatic hyperplasia (BPH) and 10 normal prostate specimens for this purpose. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for mRNA expression of mPGES-1 and Beclin-1, while MTT assays were used to ascertain the best working concentration of the mPGES-1 inhibitor (CAY10526). The effect of CAY10526 treatment on expression of Beclin-1 in DU-145 cells was studied using Western blot analysis. Localization of Beclin-1 and mPGES-1 was in endochylema. Significant differences in expression was noted among PCa, BPH and normal issues (P<0.05). Beclin-1 expression inversely correlated with mPGES-1 expression in PCa tissue (P<0.05). CAY10526 could significantly block mPGES-1 expression and the proliferation of DU-145 cells (P<0.05), while increasing Beclin-1 levels (P<0.05). Overexpression of mPGES-1 could decrease the autophagic PCa cell death. Inhibiting the expression of mPGES-1 may lead to DU-145 cell death and up-regulation of Beclin-1. The results suggest that inhibition of mPGES-1 may have therapeutic potential for PCa in the future.
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Luciferase Assay to Screen Tumour-specific Promoters in Lung Cancer
Xu, Rong,Guo, Long-Jiang,Xin, Jun,Li, Wen-Mao,Gao, Yan,Zheng, You-Xian,Guo, You-Hong,Lin, Yang-Jun,Xie, Yong-Hua,Wu, Ya-Qing,Xu, Rui-An Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Objective: Specific promoters could improve efficiency and ensure the safety of gene therapy. The aim of our study was to screen examples for lung cancer. Methods: The firefly luciferase gene was used as a reporter, and promoters based on serum markers of lung cancer were cloned. The activity and specificity of seven promoters, comprising CEACAM5 (carcinoembryonic antigen, CEA), GRP (Gastrin-Releasing Peptide), KRT19 (cytokeratin 19, KRT), SFTPB (surfactant protein B, SP-B), SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA), SELP (Selectin P, Granule Membrane Protein 140kDa, Antigen CD62, GMP) and DKK1 (Dickkopf-1) promoters were compared in lung cancer cells to obtain cancer-specific examples with strong activity. Results: The CEACAM5, DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB promoters were cloned. Furthermore, we successfully constructed recombinant vector pGL-CEACAM5 (DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB) contained the target gene. After cells were transfectedwith recombinant plasmids, we found that the order of promoter activity from high to low was SERPINB3, DKK1, SFTPB, KRT19, CEACAM5, SELP and GRP and the order for promoters regarding specificity and high potential were SERPINB3, DKK1, SELP, SFTPB, CEACAM5, KRT19 and GRP. Conclusion: The approach adopted is feasible to screen for new tumour specific promoters with biomarkers. In addition, the screened lung-specific promoters might have potential for use in lung cancer targeted gene therapy research.
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