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Cytotoxic Constituents of Psoralea corylifolia
Mar, Woong-chon,Je, Kang-Hun,Seo, Eun-Kyoung The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.3
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L (Leguminosae) with the IC_{50}$ values of 0.3 and 0.4 ug/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralene (3) from the plant. The isolates 1-3 were not active against the A54l(lung) and HepG2 (liver hepatoma) cancer cell lines.
( Woong Chon Mar ),( Ki Bong Oh ),( Sung Jin Lee ),( Jong Heon Shin ),( Kung Woo Nam ),( Kyeong Ho Kim ),( Ahrom Ham ),( Uk Koo ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1
Free radical scavenging and antioxidants have attracted attention as a way to prevent the progression of Parkinson`s disease (PD). This study was carried out to investigate the effects of n-hexane fraction from Laurus nobilis L. (Lauraceae) leaves (HFL) on dopamine (DA)-induced intracellular reactive oxygen species (ROS) production and apoptosis in human neuroblastoma SH-SY5Y cells. Compared with apomorphine (APO, IC50=18.1 uM) as a positive control, the HFL IC50 value for DA-induced apoptosis was 3.0 ug/ml, and two major compounds from HFL, costunolide and dehydrocostus lactone, were 7.3 uM and 3.6 uM, respectively. HFL and these major compounds significantly inhibited ROS generation in DA-induced SH-SY5Y cells. A rodent 6-hydroxydopamine (6-OHDA) model of PD was employed to investigate the potential neuroprotective effects of HFL in vivo. 6-OHDA was injected into the substantia nigra of young adult rats and an immunohistochemical analysis was conducted to quantitate the tyrosine hydroxylase (TH)-positive neurons. HFL significantly inhibited 6-OHDA-induced TH-positive cell loss in the substantia nigra and also reduced DA induced a-synuclein (SYN) formation in SH-SY5Y cells. These results indicate that HFL may have neuroprotective effects against DA-induced in vitro and in vivo models of PD.
Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice
( Woong Chon Mar ),( Ki Bong Oh ),( Sung Jin Lee ),( Jong Heon Shin ),( Kung Woo Nam ),( Jae Kyu Noh ),( Su Kwan Kim ),( Kyeong Ho Kim ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1
We examined the effects of essential oil from Thujopsis dolobrata Sieb. et Zucc. var. hondai Makino (EOTD) (Cupressaceae) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Treatment with EOTD twice daily for two weeks ameliorate AD-like skin lesions induced by DNCB (2,4 dinitrochlorobenzene), and clinical scores were reduced to 7.29, 7.07, and 4.5 points in the groups treated with 1.5%, 3.0%, and 6.0% extract (p<0.01) respectively, from the 15.0 score obtained using vehicle. EOTD inhibited the infiltration of mast cells into the AD-like skin lesion in NC/Nga mice (p<0.01) and also reduced serum histamine and IgE levels (p<0.05). Furthermore, it dose-dependently inhibited the release of beta-hexosaminidase from rat basophilic leukemia RBL 2H3 cells. These results indicate that EOTD reduces AD-like skin lesions by inhibiting the production of IgE and histamine, and, thus, IgE-mediated degranulation.
Woong-Chon Mar,Il-Moo Chang 한국생약학회 1987 생약학회지 Vol.18 No.1
Iridoids represent a group of natural constituents, having chemically monoterpenoid moiety with a cyclo(c)pyran ring system. They are usually found as glycosides. Several hundred iridoidal compounds have beets isolated from plants and insects and their chemical structures determined, but relatively few pharmacological works have been reported. Previously we reported that Aucubin, an iridoid glucoiside exhibited significant protective activities against carbon tetrachloride-induced hepatic damage and alphaamanitin-induced hepatic damage in mice. To further investigate this observation in relation with other iridoidal analogs, three iridoid glycosides, namely, catalpol, swertiamarin and gardenoside, isolated from traditional Chinese herbal drugs, were examined as to potential liver-protective activities against carbon tetrachlorideinduced hepatic damage in mice. As a measure of the liver protection, the following criteria were examined; effect on the duration of hypnosis produced by hexobarbital after carton tetrachloride intoxication, effects on the levels of serum transaminases like glutamic - oxalacetic transaminase(EC.2.6.1.1.) and glutamic pyruvic transaminase(EC.2.6.1.2.) and chemistry(blood urea nitrogen) and histopathological examination of mouse liver biopsy samples. Results indicate that the order of protection appears to be aucubin, swertiamarin, catalpol and gardenoside. This work was supported by a grant #RR318 from International Foundation for Science, Sweden, Stockholm,
Biodegradation of Hydrocarbons by an Organic Solvent-Tolerant Fungus, Cladosporium resinae NK-1
Oh, Ki Bong,Mar, Woong Chon,Chang, Il Moo 한국미생물 · 생명공학회 2001 Journal of microbiology and biotechnology Vol.11 No.1
A kerosene fungus of Cladosporium resinae NK-1 was examined for its ability to degrade individual n-alkanes and aromatic hydrocarbons by gas chromatography-mass spectrometry, and its organic solvent-tolerance was investigated by making use of the water-organic solvent suspension culture method. It grew on a wide range of solvents of varying hydrophobicities and it was found to have tolerance to various kinds of toxic organic solvents (10%, v/v) such as n-alkanes, cyclohexane, xylene, styrene, and toluene. A hydrocarbon degradation experiment indicated that NK-1 had a greater n-alkane degrading ability compared to that of the other selected strains. C. resinae NK-1, which could utilize 8-16 carbon chain-length n-alkanes of medium chain-length as a carbon source, could not assimilate the shorter chain-length n-alkanes and aromatic hydrocarbons tested so far. The n-alkane degrading enzyme activity was found in the mycelial extract of the organism.
술류에 관한 연구(Ⅱ) : 한국산 창술과 백술의 사염화탄소 간독성에 대한 보간효과 비교
장일무(Il-Moo Chang),마응천(Woong-Chon Mar),김제훈(Jae Hoon Kim),염정록(Jeong Rok Youm),Michio TakidoMichio Takido 한국생약학회 1989 생약학회지 Vol.20 No.2
Traditional herbal drugs of Korea, namely, Atractylodes Rhizome(蒼朮) and Atractylodes Rhizome White(白朮) which are derived from an old-grown rhizome and a newly-grown rhizome of Atractylodes japonica Koidz. (Compositae), respectively, were investigated their potential liver-protective activities against hepatoto xicity induced by CCl₄ intoxication in mice. Each herbal drug was extracted separately with chloroform, methanol and butanol. No extract of Atractylodes Rhizome showed a singnificant reduction of the duration of hypnosis produced by hexobarbital after CCl₄ intoxication in mice. In addition, the the treatments of Atractlyodes Rhizome extracts produced no decrease of aspartate aminotransferase(EC 2.6.1.1) activity in serum. However, the methanol extract of Atractylodes Rhizome White exhibited a marked protection from hepatotoxicity induced by CCl₄ intoxication in mice. It produced significant reductions of the duration of hypnosis and serum enzyme activity, but no other exract showed liver-protectivie activity against CCl₄-induced hepatotoxicity.
Lee, Sung-Jin,Lee, Ik-Soo,Mar, Woong-Chon The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.10
Activated macrophages express inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2), and produce excessive amounts of nitric oxide (NO) and prostaglandin E$_2$ (PGE$_2$), which play key roles in the processes of inflammation and carcinogenesis. The root of Paeonia lactiflora Pall., and the root cortex of Paeonia suffruticosa Andr., are important Chinese crude drugs used in many traditional prescriptions. 1,2,3,4,6-penta-O-galloyl-$\beta$-D-glucose (PGG) is a major bioactive constituent of both crude drugs. PGG has been shown to possess potent anti-oxidant, anti-mutagenic, anti-proliferative and anti-invasive effects. In this study, we examined the inhibitory effects of 1,2,3,4,6-penta-O-galloyl-$\beta$-D-glucose (PGG) isolated from the root of Paeonia lactiflora Pall. on the COX-2 and iNOS activity in LPS-activated Raw 264.7 cells, COX-1 in HEL cells. To investigate the structure-activity relationships of gallate and gallic acid for the inhibition of iNOS and COX-2 activity, we also examined (-)-epigallocatechin gallate (EGCG), gallic acid, and gallacetophenone. The results of the present study indicated that PGG, EGCG, and gallacetophenone treatment except gallic acid significantly inhibited LPS-induced NO production in LPS-activated macrophages. All of the four compounds significantly inhibited COX-2 activity in LPS-activated macrophages. Among the four compounds examined, PGG revealed the most potent in both iNOS ($IC_{50}$ = 18 $\mu\textrm{g}/mL$) and COX-2 inhibitory activity (PGE$_2$: $IC_{50}$ = 8 $\mu\textrm{g}/mL$ and PGD$_2$: $IC_{50}$ = 12 $\mu\textrm{g}/mL$), respectively. Although further studies are needed to elucidate the molecular mechanisms and structure-activity relationship by which PGG exerts its inhibitory actions, our results suggest that PGG might be a candidate for developing anti-inflammatory and cancer chemopreventive agents.
Kim, Young-Mi,Chang, Il-Moo,Mar, Woong-Chon The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
NAD(P)H:quinone reductase (QR) is one of the protective phase II enzymes against toxicity that accomplishes the capacity of detoxification by modulating the effects of mutagens and carcinogens. The detoxification mechanism is that quinone reductase promotes the 2-electron reduction of quinones to hydroquinones which are less reactive. This study is to search new inducers of quinone reductase from natural products, which can be used as cancer chemopreventive agents. Plant extracts were evaluated by using quinone reductase generating system With Hepa 1c1c7 murine hepatoma cell lines for enzyme inducing properties and crystal violet staining method for the measurement of cytotoxicity provoked. We have tested approximately 106 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from 100% methanol extracts of natural products. The ethyl acetate fractions of Vitex rotundifolia $(fruits,\;2FC:\;12.7\;{\mu}g/ml)$, Cnidium officinale $(aerial\;parts,\;2FC:\;10.5\;{\mu}g/ml)$, Chrysanthemum sinese $(flowers,\;2FC:\;17.4{\mu}g/ml)$ and the hexane fractions of Angelica gigas $(roots,\;2FC:\;13.2\;{\mu}g/ml)$, Smilax china $(roots,\;2FC:\;l1.9\;{\mu}g/ml)$, Sophora flavescens $(roots,\;2FC:\;16.3\;{\mu}g/ml)$ revealed the significant induction of quinone reductase in a murine hepatic Hepa 1c1c7 cell culture system.
Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
( Sung Jin Lee ),( Hyun Jin Ahn ),( Kung Woo Nam ),( Kyeong Ho Kim ),( Woong Chon Mar ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.5
The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mM H2O2, as assessed by 4`,6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.