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Choi, Mun Ju,Chandra, Girish,Lee, Hyuk Woo,Hou, Xiyan,Choi, Won Jun,Phan, Khai,Jacobson, Kenneth A.,Jeong, Lak Shin Royal Society of Chemistry 2011 Organic & biomolecular chemistry Vol.9 No.20
<P>The stereoselective synthesis of truncated 3′-aminocarbanucleosides 4a–d<I>via</I> a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A<SUB>3</SUB> adenosine receptor are described.</P> <P>Graphic Abstract</P><P>The stereoselective synthesis of truncated 3′-aminocarbanucleosides <I>via</I> a stereo- and regioselective conversion of a diol to bromoacetate and their binding affinity towards the human A<SUB>3</SUB> adenosine receptor are described. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1ob05853c'> </P>
Steady and Dynamic Shear Rheological Properties of Buckwheat Starch-galactomannan Mixtures
Choi, Dong-Won,Chang, Yoon-Hyuk The Korean Society of Food Science and Nutrition 2012 Preventive Nutrition and Food Science Vol.17 No.3
This study investigated the effects of galacomannans (guar gum, tara gum, and locust bean gum) on the rheological properties of buckwheat starch pastes under steady and dynamic shear conditions. The power law and Casson models were applied to describe the flow behavior of the buckwheat starch and galactomannan mixtures. The values of the apparent viscosity (${\eta}_{a,100}$), consistency index (K), and yield stress (${\sigma}_{oc}$) for buckwheat starch-galactomannan mixtures were significantly greater than those for the control, indicating that there was a high synergism of the starch with galactomannans. The magnitudes of storage modulus (G') and loss modulus (G") for the starch-galactomannan mixtures increased with increasing frequency (${\omega}$). The dynamic moduli (G', G"), and complex viscosity (${\eta}^*$) for the buckwheat starch-galactomannan mixtures were significantly higher than those for the control.
Reduction of Off-State Currents in Silicon on Glass Thin Film Transistor by Off-State Bias Stress
Choi, Jae Won,Cheon, Jun Hyuk,Oh, Jae Hwan,Jang, Jin,Kim, Sung-Chul,Ahn, Ji-Su,Williams, C. A. Kosik,Couillard, J. G. The Electrochemical Society 2010 Electrochemical and solid-state letters Vol.13 No.7
Prevalence and Clinical Characteristics of the Metabolic Syndrome in Middle-Aged Korean Adults
( Hyuk Sang Kwon ),( Yong Moon Park ),( Hye Jung Lee ),( Jin Hee Lee ),( Yoon Hee Choi ),( Seung Hyun Ko ),( Jung Min Lee ),( Sung Rae Kim ),( So Young Kang ),( Won Chul Lee ),( Myung Sook Ahn ),( Jae 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.4
Background : The aim of this study was to analyze the prevalence and clinical characteristic of the metabolic syndrome of adults, over 40 years old, living in Korea. Methods : This study was carried out for 2 years, 2003-2004, on total 5,330 individuals (2,197 men and 3,133 women) selected by the stratified random cluster sampling among adults over 40 years old. Metabolic syndrome was defined based on both the NCEP-ATP III criteria and Modified ATP III criteria applying the WHO-APR (Asian Pacific Region)`s abdominal obesity criteria (waist circumference > 90 cm in men, 80 cm in women) instead of NCEP-ATP III criteria. Results : Using NCEP-ATP III criteria, the age-adjusted overall prevalence of metabolic syndrome was 24.8% (17.6% in men, 30.0% in women). Age-adjusted overall prevalence of metabolic syndrome as defined by modified-ATP III criteria was 34.3% (26.3% in men, 40.1% in women). The prevalence of metabolic syndrome for each age group (40-49, 50-59, 60-69, ≥ 70) in men was as follows: 18.8%, 17.4%, 18.3%, 14.5%. In women: 22.3%, 32.7%, 39.9%, 39.3%. The prevalence of hypertriglyceridemia (triglycerides ≥ 1.7 mmol/l) was well correlated with the changing pattern of the prevalence of metabolic syndrome both in men and women. Conclusions : The peak age of metabolic syndrome in men was age 40 through 49, and the prevalence decreased with aging. Therefore, early intervention for risk factors of metabolic syndrome might be required in men. On the other hand, prevention for cardiovascular disease will be needed for perimenopausal women due to considerably increased prevalence in the age 50 through 59.
Won, Ki-Bum,Han, Donghee,Lee, Ji Hyun,Lee, Sang-Eun,Sung, Ji Min,Choi, Su-Yeon,Chun, Eun Ju,Park, Sung Hak,Han, Hae-Won,Sung, Jidong,Jung, Hae Ok,Chang, Hyuk-Jae Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.266 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited.</P> <P><B>Methods</B></P> <P>We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3.0 (2.0–4.4) years. The change in CAC was compared base on OGC status. OGC was defined as a follow-up hemoglobin A1C (HbA1C) of <7.0%, and CAC progression was defined by a square root (√) transformed difference between the baseline and follow-up CAC scores (Δ √transformed CAC) of ≥2.5.</P> <P><B>Results</B></P> <P>Despite no significant difference in the baseline CAC scores, the incidence of CAC progression was lower in the OGC group than in the non-OGC group (45.4% vs. 51.7%; <I>p</I> < 0.013). The two groups differed in the Δ √transformed (OGC, 3.8 ± 6.4; non-OGC, 4.7 ± 6.9; <I>p</I> = 0.016) and annualized Δ √transformed CAC (OGC, 1.1 ± 2.4; non-OGC, 1.4 ± 2.6; <I>p</I> = 0.010) scores. Subgroup analysis showed that OGC significantly reduced the risk of CAC progression in patients aged <65 years and in: smokers, and patients with a body mass index of <25 kg/m<SUP>2</SUP>, dyslipidemia, and baseline CAC scores between 1–100 and >400. In multivariate regression analysis, OGC was independently associated with a reduced risk of CAC progression (odds ratio, 0.745, 95% confidence interval, 0.601–0.924; <I>p</I> = 0.007).</P> <P><B>Conclusion</B></P> <P>OGC attenuated the progression of coronary artery calcification in asymptomatic patients with diabetes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In clinical practice, the significance of optimal glycemic control (OGC) is emphasized in patients with diabetes. </LI> <LI> Data on the impact of OGC on coronary artery calcification (CAC) progression in patients with diabetes has been limited. </LI> <LI> This study identified that OGC was independently associated with a reduced risk of CAC progression in asymptomatic patients with diabetes. </LI> </UL> </P>
Choi, So Young,Park, Si Jae,Kim, Won Jun,Yang, Jung Eun,Lee, Hyuk,Shin, Jihoon,Lee, Sang Yup Nature Publishing Group, a division of Macmillan P 2016 Nature biotechnology Vol.34 No.4
<P>Poly(lactate-co-glycolate) (PLGA) is a widely used biodegradable and biocompatible synthetic polymer. Here we report one-step fermentative production of PLGA in engineered Escherichia coli harboring an evolved polyhydroxyalkanoate (PHA) synthase that polymerizes D-lactyl-CoA and glycolyl-CoA into PLGA. Introduction of the Dahms pathway enables production of glycolate from xylose. Deletion of ptsG enables simultaneous utilization of glucose and xylose. An evolved propionyl-CoA transferase converts D-lactate and glycolate to D-lactyl-CoA and glycolyl-CoA, respectively. Deletion of adhE, frdB, pflB and poxB prevents by-product formation. We also demonstrate modulation of the monomer fractions in PLGA by overexpressing ldhA and deleting dld to increase the proportion of D-lactate or by deleting aceB, glcB, glcD, glcE, glcF and glcG to increase the proportion of glycolate. Incorporation of 2-hydroxybutyrate is prevented by deleting ilvA or feeding strains with l-isoleucine. The utility of our approach for generating diverse forms of PLGA is shown by the production of copolymers containing 3-hydroxybutyrate, 4-hydroxybutyrate or 2-hydroxyisovalerate.</P>
Won Ho Cho,Hyuk Jin Choi,Kyoung Hyup Nam,Jae Il Lee 대한뇌혈관외과학회 2015 Journal of Cerebrovascular and Endovascular Neuros Vol.17 No.4
Contrast extravasation on computed tomography angiography (CTA) is rare but becoming more common, with increasing use of CTA for various cerebral vascular diseases. We report on two cases of spontaneous subarachnoid hemorrhage (SAH) in which the CTA showed an upper basilar trunk saccular lesion suggesting ruptured aneurysm. However, immediate subsequent digital subtraction angiography (DSA) failed to show a vascular lesion. In one case, repeated follow up DSA was also negative. The patient was treated conservatively and discharged without any neurologic deficit. In the other case, the patient showed sudden mental deterioration on the third hospital day and her brain CT showed rebleeding. The immediate follow up DSA showed contrast stagnation in the vicinity of the upper basilar artery, suggestive of pseudoaneurysm. Double stents deployment at the disease segment was performed. Due to the frequent use of CTA, contrast extravasation is an increasingly common observation. Physicians should be aware that basilar artery extravasation can mimic the appearance of an aneurysm.
Modeling and Analysis of PMSMs under Inter Turn Short Faults
Choi, Jun-Hyuk,Gu, Bon-Gwan,Won, Chung-Yuen The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.5
A model of a permanent magnet synchronous motor (PMSM) with an inter turn short fault is proposed using a deformed flux model. The deformed flux model includes not only the fault winding flux information but also the inductance variation of the healthy winding considering the configuration of the winding distribution. With the deformed flux model and the positive sequence current assumption, the proposed model is derived in the positive and negative sequence synchronous reference frame (SRF). The finite elements method (FEM) simulation is applied to validate the proposed PMSM model with inter turn short fault.
Choi, Rihwa,Lee, Jeongho,Park, Hyung-Doo,Park, Jong Eun,Kim, Yong Hyuk,Ki, Chang-Seok,Lee, Soo-Youn,Song, Junghan,Kim, Jong-Won,Lee, Dong Hwan De Gruyter 2017 Journal of pediatric endocrinology & metabolism Vol.30 No.11
<P>Background: The accurate interpretation of sequence variation is critical for successful molecular diagnoses. It is also fundamental to the accurate diagnosis and treatment of phenylketonuria (PKU). This study aims to evaluate the significance of the c.158G > A (p.Arg53His) variant in the PAH gene, which was previously reported to be a pathogenic mutation that results in decreased phenylalanine hydroxylase enzyme activity in hyperphenylalaninemia (HPA) patients. Methods: Seven unrelated Korean patients with HPA genotyped with the c.158G > A variant were included in this study. The variant c.158G > A was classified by the standards and guidelines for the interpretation of sequence variants by the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Results: By both directly collecting genetic data and comprehensively reviewing the existing literature, we found that this variant is more appropriately classified as 'Likely benign' rather than pathogenic. The allele's frequency is 2.57% in the general Korean population, which was greater than expected for phenylketonuria. This variant was observed to be homozygous in healthy subjects and was also observed in cis with other pathogenic variants. It is common in East Asian populations (especially in Koreans) compared to Western populations. There is a possibility that it causes decreased enzyme activity without leading to the full pathology of phenylketonuria. Conclusions: This study expands our understanding of the consequences of variation in PAH and its relationship to HPA.</P>