http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
국소 전립선암에서 예측 모형으로서의 전립선특이항원속도의 역할
함원식(Won Sik Ham) 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.3
It has been reported that prostate-specific antigen (PSA) velocity (PSAV) is statistically associated with many prostate cancer outcomes, including those related to early detection. However, the clinical use of a marker should depend on clinical and statistical significance. Before PSAV is used to inform decisions such as whether to perform a biopsy, evidence should be clear that doing so would improve clinical outcome. Therefore, the use of PSAV as a marker in localized prostate cancer has sometimes been described as controversial. The purpose of this review is to introduce the conflicting opinions on the role of PSAV as a prognostic tool in localized prostate cancer and the usefulness of PSAV in real clinical practice.
전립선암의 호르몬 불응성과 PTEN, CD44 발현양상의 연관성 분석
함원식(Won Sik Ham),박재원(Jae Won Park),조강수(Kang Su Cho),이창기(Chang Kee Lee),최영득(Young Deuk Choi),홍성준(Sung Joon Hong) 대한비뇨기종양학회 2012 대한비뇨기종양학회지 Vol.10 No.1
Purpose: Most prostate cancers (PCs) ultimately progress to castration resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). Because cancer stem cells survive ADT, which can lead to tumor recurrence and understanding the molecular changes that occur after ADT would helpful for finding novel therapies targeting CRPC, we analyzed the expression of CD44, a stem cell marker in radical prostatectomy samples after ADT. Materials and Methods: PTEN and CD44 expression profiles were determined by microarray or real-time PCR in 107 radical prostatectomy specimens from patients given neoadjuvant ADT. Pathological regressive changes and the correlation of postoperative biochemical failure with PTEN and CD44 expression were analyzed. Results: As the PC tissues had minimal regression effects after ADT, they showed significantly advanced pathological stage (p=0.001), PTEN inactivation (p<0.001), and high CD44 expression (p<0.001). The PTEN inactivation group showed a significantly higher probability of positive CD44 expression compared to the non-PTEN inactivation group (OR 10.5, 95% CI 4.0 to 27.6, p<0.001). Cox regression analysis revealed that seminal vesicle invasion, biopsy Gleason score, and CD44 expression were significantly associated with the time to biochemical recurrence. Conclusions: PC tissues refractory to ADT showed PTEN inactivation with high CD44 expression. The PTEN inactivation group showed a significantly high probability of positive CD44 expression. Our results support that the PTEN/PI3K/Akt pathways are necessary for prostate cancer stem cell maintenance.
Nephrometry 점수 체계의 임상적 유용성에 대한 고찰
함원식(Won Sik Ham) 대한비뇨기종양학회 2014 대한비뇨기종양학회지 Vol.12 No.3
As a result of the expanding indications for partial nephrectomy and the need for standardized reporting of outcome, several groups have attempted to generate methods of preoperative scoring to quantify renal tumor size, location, and depth based on preoperative imaging findings. Identifying predictive characteristics of renal tumors that can be used to identify risk of prolonged warm ischemia time or surgical complications was the objective of these scoring systems. It has been reported that these nephrometry scoring systems are statistically associated with partial nephrectomy outcomes, including not only early surgical complications but also pathological outcomes. However, the clinical use of these nephrometry scoring systems should depend on clinical and statistical significance, and the use of nephrometry score as a prediction tool in outcome of partial nephrectomy has sometimes been described as controversial. The purpose of this review is to introduce the conflicting opinions on the usefulness of nephrometry scoring systems in real clinical practice.
Jee Soo Park(박지수),Won Sik Jang(장원식),Sung Joon Hong(홍성준),Young Deuk Choi(최영득),Koon Ho Rha(나군호),Won Sik Ham(함원식) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.1
Purpose: To report an association between prostate cancer and vitamin D levels among different races in a single population in the United States. Materials and Methods: We investigated whether there was an association between vitamin D level and prostate cancer in different races in the United States. We used data collected from 1,363 men during the National Health and Nutrition Examination Survey 2007–2008. Multivariate logistic regression analysis was used to evaluate the independent associations between vitamin D levels (not only 25-hydroxyvitamin D [25(OH)D], but also 25(OH)D2 and D3) and prostate cancer. Association between vitamin D levels and prostate specific antigen level was also analyzed in non-Hispanic white males without prostate cancer. Results: Older age was significantly associated with prostate cancer in all races (p<0.05), whereas vitamin D (p=0.024), especially 25(OH)D2 (p=0.027) was significantly higher only in non-Hispanic white males. There was no difference in vitamin D levels between non-Hispanic white males with a prostate specific antigen concentration >3 ng/mL and ≤3 ng/mL. Conclusions: This study revealed a positive association between vitamin D, especially 25(OH)D2, and prostate cancer only in non-Hispanic white males. And vitamin D was not associated with prostate specific antigen level causing detection bias.
근치적 전립선절제술 후 요실금 발생 환자에서의 항콜린제 처방에 대한 비뇨기과 의사의 실태조사
방우진(Woo Jin Bang),주관중(Kwan Joong Joo),조진선(Jin Seon Cho),전성수(Seong Soo Jeon),백성현(Sung Hyun Paick),성도환(Do Hwan Seong),김홍섭(Hong Sup Kim),함원식(Won Sik Ham),홍성준(Sung Joon Hong) 대한비뇨기종양학회 2012 대한비뇨기종양학회지 Vol.10 No.2
Purpose: We surveyed the actual use of anticholinergics for urinary incontinence after radical prostatectomy among the practicing urologists. Materials and Methods: 142 urologist members of the Korean Urological Oncology Society were given surveys through conventional mail and e-mail with 76 members returning responses. Answering for the number of radical prostatectomy performed each year, 21 urologists responded more than 50 cases, 37 responded 10 to 50 cases, 11 responded 5 to 10 cases, and 7 said 1 to 5 cases. Concerning primary approach, retropubic approach surgery, laparoscopic surgery, robotic surgery and perineal approach surgery each had 39, 19, 17, and 1, respectively. Results: Among 76 participants, 64 (84%) acknowledged prescribing anticholinergics after prostatectomy depending on symptoms. For post-op indication of anticholinergics, 43 members responded significant incontinence symptoms, while 19 answered frequent urination. Concerning the initiation of medication, 52 answered when symptoms arise after catheter removal. For duration of anticholinergics, less than 30 days, 31-60 days, 61-90 days, more than 90 days each received 8, 17, 24, and 15 votes from participants, respectively. Finally, 57 members thought the use of anticholinergics were beneficial in treating urinary incontinence after radical prostatectomy. Conclusions: Over 80% of survey participants acknowledged prescribing anticholinergics to urinary incontinence patients according to symptoms, and 75% concurred with their usefulness. But, there is no specified protocol of anticholinergics use for urinary incontinence after radical prostatectomy.