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Maxillary space closure using a digital manufactured Mesialslider in a single appointment workflow
Wilhelmy Lynn,Willmann Jan H.,Tarraf Nour Eldin,Wilmes Benedict,Drescher Dieter 대한치과교정학회 2022 대한치과교정학회지 Vol.52 No.3
New digital technologies, many involving three-dimensional printing, bring benefits for clinical applications. This article reports on the clinical procedure and fabrication of a skeletally anchored mesialization appliance (Mesialslider) using computer-aided design/computer-aided manufacturing (CAD/CAM) for space closure of a congenitally missing lateral incisor in a 12-year-old female patient. The insertion of the mini-implants and appliance was performed in a single appointment. Bodily movement of the molars was achieved using the Mesialslider. Anchorage loss, such as deviation of the anterior midline or palatal tilting of the anterior teeth, was completely avoided. CAD/CAM facilitates safe and precise insertion of mini-implants. Further, mini-implants can improve patient comfort by reducing the number of office visits and eliminating the need for orthodontic bands and physical impressions.
Clinical photoacoustic imaging of cancer
Keerthi S. Valluru,Juergen K. Willmann 대한초음파의학회 2016 ULTRASONOGRAPHY Vol.35 No.4
Photoacoustic imaging is a hybrid technique that shines laser light on tissue and measures optically induced ultrasound signal. There is growing interest in the clinical community over this new technique and its possible clinical applications. One of the most prominent features of photoacoustic imaging is its ability to characterize tissue, leveraging differences in the optical absorption of underlying tissue components such as hemoglobin, lipids, melanin, collagen and water among many others. In this review, the state-of-the-art photoacoustic imaging techniques and some of the key outcomes pertaining to different cancer applications in the clinic are presented.
Ultrasound-guided drug delivery in cancer
Sayan Mullick Chowdhury,이태화,Jürgen K. Willmann 대한초음파의학회 2017 ULTRASONOGRAPHY Vol.36 No.3
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.
β-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice
Lehwald, Nadja,Tao, Guo–,Zhong,Jang, Kyu Yun,Papandreou, Ioanna,Liu, Bowen,Liu, Bo,Pysz, Marybeth A.,Willmann, Jü,rgen K.,Knoefel, Wolfram T.,Denko, Nicholas C.,Sylvester, Karl G. Elsevier 2012 Gastroenterology Vol.143 No.3
<P><B>Background & Aims</B></P> <P>Wnt signaling regulates hepatic function and nutrient homeostasis. However, little is known about the roles of β-catenin in cellular respiration or mitochondria of hepatocytes.</P> <P><B>Methods</B></P> <P>We investigated β-catenin's role in the metabolic function of hepatocytes under homeostatic conditions and in response to metabolic stress using mice with hepatocyte-specific deletion of β-catenin and their wild-type littermates, given either saline (sham) or ethanol (as a model of binge drinking and acute ethanol intoxication).</P> <P><B>Results</B></P> <P>Under homeostatic conditions, β-catenin-deficient hepatocytes demonstrated mitochondrial dysfunctions that included impairments to the tricarboxylic acid cycle and oxidative phosphorylation (OXPHOS) and decreased production of adenosine triphosphate (ATP). There was no evidence for redox imbalance or oxidative cellular injury in the absence of metabolic stress. In mice with β-catenin-deficient hepatocytes, ethanol intoxication led to significant redox imbalance in the hepatocytes and further deterioration in mitochondrial function that included reduced OXPHOS, fatty acid oxidation (FAO), and ATP production. Ethanol feeding significantly increased liver steatosis and oxidative damage, compared with wild-type mice, and disrupted the ratio of nicotinamide adenine dinucleotide. β-catenin-deficient hepatocytes also had showed disrupted signaling of Sirt1/peroxisome proliferator-activated receptor-α signaling.</P> <P><B>Conclusions</B></P> <P>β-catenin has an important role in the maintenance of mitochondrial homeostasis, regulating ATP production via the tricarboxylic acid cycle, OXPHOS, and fatty acid oxidation; β-catenin function in these systems is compromised under conditions of nutrient oxidative stress. Reagents that alter Wnt-β-catenin signaling might be developed as a useful new therapeutic strategy for treatment of liver disease.</P>
( Tae Kyoung Kim ),( Seung Yeon Noh ),( Stephanie R Wilson ),( Yuko Kono ),( Fabio Piscaglia ),( Hyun-jung Jang ),( Andrej Lyshchik ),( Christoph F. Dietrich ),( Juergen K. Willmann ),( Alexander Veze 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.4
Medical imaging plays an important role in the diagnosis and management of hepatocellular carcinoma (HCC). The Liver Imaging Reporting and Data System (LI-RADS) was initially created to standardize the reporting and data collection of CT and MR imaging for patients at risk for HCC. As contrast-enhanced ultrasound (CEUS) has been widely used in clinical practice, it has recently been added to the LI-RADS. While CEUS LI-RADS shares fundamental concepts with CT/MRI LI-RADS, there are key differences between the modalities reflecting dissimilarities in the underlying methods of image acquisition and types of contrast material. This review introduces a recent update of CEUS LI-RADS and explains the key differences from CT/MRI LI-RADS. (Clin Mol Hepatol 2017;23:280-289)