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      • KCI등재

        Multi-objective Fuzzy-optimization of Crowbar Resistances for the Low-Voltage Ride-through of Doubly Fed Induction Wind Turbine Generation Systems

        Wenjuan Zhang,Haomiao Ma,Junli Zhang,Lingling Chen,Yang Qu 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.4

        This study investigates the multi-objective fuzzy optimization of crowbar resistance for the doubly fed induction generator (DFIG) low-voltage ride-through (LVRT). By integrating the crowbar resistance of the crowbar circuit as a decision variable, a multi-objective model for crowbar resistance value optimization has been established to minimize rotor overcurrent and to simultaneously reduce the DFIG reactive power absorbed from the grid during the process of LVRT. A multi-objective genetic algorithm (MOGA) is applied to solve this optimization problem. In the proposed GA, the value of the crowbar resistance is represented by floating-point numbers in the GA population. The MOGA emphasizes the non-dominated solutions and simultaneously maintains diversity in the non-dominated solutions. A fuzzy-set-theory-based is employed to obtain the best solution. The proposed approach has been evaluated on a 3 MW DFIG LVRT. Simulation results show the effectiveness of the proposed approach for solving the crowbar resistance multi-objective optimization problem in the DFIG LVRT.

      • KCI등재

        Identification of S-Nitrosylation of Proteins of Helicobacter pylori in Response to Nitric Oxide Stress

        Wei Qu,Yabin Zhou,Yundong Sun,Ming Fang,Han Yu,Wenjuan Li,Zhifang Liu,Jiping Zeng,Chunyan Chen,Chengjiang Gao,Jihui Jia 한국미생물학회 2011 The journal of microbiology Vol.49 No.2

        Innate and adaptive immune responses are activated in humans when Helicobacter pylori invades the gastric mucosa. Nitric oxide (NO) and reactive nitrogen species are important immune effectors, which can exert their functions through oxidation and S-nitrosylation of proteins. S-nitrosoglutathione and sodium nitroprusside were used as NO donors and H. pylori cells were incubated with these compounds to analyze the inhibitory effect of NO. The suppressing effect of NO on H. pylori has been shown in vitro. Furthermore,the proteins modified by S-nitrosylation in H. pylori were identified through the biotin switch method in association with matrix-assisted laser desorption ionization/time-of-flight tandem mass spectrometry (MALDITOF-MS/MS). Five S-nitrosylated proteins identified were a chaperone and heat-shock protein (GroEL),alkyl hydroperoxide reductase (TsaA), urease alpha subunit (UreA), HP0721, and HP0129. Importantly,S-nitrosylation of TsaA and UreA were confirmed using purified recombinant proteins. Considering the importance of these enzymes in antioxidant defenses, adherence, and colonization, NO may exert its antibacterial actions by targeting enzymes through S-nitrosylation. Identification of protein S-nitrosylation may contribute to an understanding of the antibacterial actions of NO. Our findings provide an insight into potential targets for the development of novel therapeutic agents against H. pylori infection.

      • SCIESCOPUSKCI등재

        Multi-objective Fuzzy-optimization of Crowbar Resistances for the Low-Voltage Ride-through of Doubly Fed Induction Wind Turbine Generation Systems

        Zhang, Wenjuan,Ma, Haomiao,Zhang, Junli,Chen, Lingling,Qu, Yang The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.4

        This study investigates the multi-objective fuzzy optimization of crowbar resistance for the doubly fed induction generator (DFIG) low-voltage ride-through (LVRT). By integrating the crowbar resistance of the crowbar circuit as a decision variable, a multi-objective model for crowbar resistance value optimization has been established to minimize rotor overcurrent and to simultaneously reduce the DFIG reactive power absorbed from the grid during the process of LVRT. A multi-objective genetic algorithm (MOGA) is applied to solve this optimization problem. In the proposed GA, the value of the crowbar resistance is represented by floating-point numbers in the GA population. The MOGA emphasizes the non-dominated solutions and simultaneously maintains diversity in the non-dominated solutions. A fuzzy-set-theory-based is employed to obtain the best solution. The proposed approach has been evaluated on a 3 MW DFIG LVRT. Simulation results show the effectiveness of the proposed approach for solving the crowbar resistance multi-objective optimization problem in the DFIG LVRT.

      • KCI등재

        Optimization of Process Conditions for Production of Angiotensin IConverting Enzyme (ACE) Inhibitory Peptides from Vital Wheat Gluten using Response Surface Methodology

        Rosemond Godbless Dadzie,Haile Ma,Ernest Ekow Abano,Wenjuan Qu,Shuyun Mao 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.6

        The degree of hydrolysis (DH) and angiotensinI-converting enzyme (ACE)-inhibitory activity of vitalwheat gluten (VWG) hydrolyzed using Alcalase wereinvestigated using Box-Behnken response surfacemethodology (RSM). The mean responses were fitted to asecond order polynomial to obtain regression equations. The enzyme-substrate ratio and the hydrolysis time increasedthe DH significantly (p<0.05). The substrate concentrationwas the only significant linear term leading to an increasein ACE-inhibitory activity. The optimized conditions of asubstrate concentration of 5.04%, an enzyme-substrateratio 5.94%, and a hydrolysis time 30.79 min gave a pointprediction of a 12.74% DH and 82.28% ACE-inhibitoryactivity. Analytical results from confirmatory experimentwere a 12.22%±0.5 DH and a 78.93%±1.07 ACEinhibitoryactivity. The optimized conditions of the studyprovide useful information to the functional food andbeverage industries to enhance the anti-hypertensiveactivities of peptides from VWG.

      • KCI등재

        Probiotics-loaded microcapsules from gas-assisted microfluidics for inflammatory bowel disease treatment

        Xiaowei Yang,Cuihong Li,Hai Yu,Jinping Tang,Qinfang Wu,Wenjuan Qu 한국고분자학회 2023 Macromolecular Research Vol.31 No.8

        Inflammatory bowel disease (IBD) is a kind of chronic inflammatory disease that is difficult to cure completely and may cause cancer. Modulating the intestinal flora is believed to be a feasible approach for IBD treatment. However, the traditional probiotics delivery systems often suffer from the inactivation caused by gastric acid. Herein, we proposed a novel probiotics-loaded microcapsule generated from a gas-assisted microfluidic platform. The microcapsules were composed of alginate shells and probiotics-containing cores, and exhibited good sphericity and biocompatibility, and had an average size of about 325 μm and a coefficient of variation of 2.57%. When the probiotics-loaded microcapsules were used for the IBD treatment of mice, they displayed good therapeutic effects in modulating oxidative stress and inflammation as well as protecting the intestinal barrier. These features indicate that the prepared probiotics-loaded microcapsules could be used as new materials for IBD treatment.

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