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RISS 인기검색어
- 검색키워드
- 저자 : Weijie Su (검색결과 4 건)
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Prognostic Significance of p53, Ki-67 and COX-2 in Gastric Cancer
Su Hyun Kim,Won Cheol Park,Min Sung Kim,Sung Soo Kim,Weijie He,Young Don Min 조선대학교 의학연구원 2017 The Medical Journal of Chosun University Vol.42 No.2
The clinical importance of biologic markers remains elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of p53, Ki-67, and COX-2 in gastric cancer. This retrospective study examined based on medical records of postoperative immunohistochemical test of 176 patients who demonstrated high expression of all three biological markers being tested (p53, Ki-67, and COX-2), among 357 gastric cancer patients who underwent surgical resection consecutively. This study demonstrates the correlation with biologic marker between clinical relationship and recurrence free survival (RFS). A positive correlation was observed between the expression of Ki-67 and p53, and a positive correlation was also observed between the expression of Ki-67 and COX-2 Expression of p53 did not correlate with any of the clinicopathological variables examined. Both Ki-67 and COX-2 expression significantly correlated with tumor depth, classified as early gastric cancer and advanced gastric cancer. The expression of COX-2 significantly correlated with tumor differentiation, with more tumors being of the undifferentiated type than of the differentiated type in the COX-2 positive group. A significant difference between p53 and RFS, also COX-2 expression and RFS was observed. This study showed that only p53 and COX-2 have significantly correlated with the RFS of gastric cancer.
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Han, Bo,Yoon, Soonseek,Su, Jingliang,Han, H.R.,Wang, Mei,Qu, Weijie,Zhong, Daibin Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.12
The antioxidant enzymes, lipid peroxidation and free radicals assessment were made of the effects of selenium, copper and magnesium on bovine endemic fluorosis under high fluoride, low selenium and low copper productive conditions. Thirty-two beef cattle were selected from high fluoride area, and randomly divided into four groups with eight cattle each as follows: (1) high fluoride control group (HFC); (2) supplemented group with 0.25 mg/kg selenium (HFSe); (3) supplemented group with 15 mg/kg copper (HFCu) and (4) supplemented group with 0.25 mg/kg selenium+15 mg/kg copper+1 mg/kg magnesium (HFSeCuMg) per day for 83 days. Moreover, eight beef cattle were selected from non-high fluoride area as normal control group. Blood samples were collected from cattle on 0 d, 30 d and 83 d respectively, to analyze the enzyme activities and concentration of GSH-px, CAT, SOD, MDA and free radicals. The results showed that the contents of free radicals and MDA in HFC group were significantly higher, and the whole blood GSH-px, CAT, erythrocyte SOD activities were lower than the normal control group. Free radicals, metabolic imbalance and antioxidant disorder therefore, play an important role in fluorosis. However, GSH-px, CAT and SOD activities in HFSe group and HFSeCuMg group at 30 d and 83 d were markedly higher than the same groups at the 0 d and the HFC group at the same time. Likewise, there was a corresponding reduction in the contents of free radicals and MDA. These findings indicated that supplementation with selenium, copper and magnesium elevated high fluoride bovine antioxidant enzymes, and decreased MDA and free radicals contents. But, the activities of supplementation selenium group did not increase until day 83. These results demonstrated that fluorosis was associated with lower serum Se and Cu levels than in the control, and it was therefore concluded that fluorosis is associated with decreased serum levels of these minerals. Long-term high fluoride intake under productive condition enhances oxidative stress in the blood, thereby disturbing the antioxidant defense of cattle. Increased oxidative stress could be one of the mediating factors in the pathogenesis of toxic manifestations of fluoride. It is benefical for high fluoride cattle supplemented with proper selenium, copper and magnesium to increase fluoride excretion and obtain the protective impact of the activity of oxidative enzymes, and to decrease lipid peroxidation and free radicals contents.
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Recent Developments in the Use of Intralesional Injections Keloid Treatment
Perdanasari, Aurelia Trisliana,Lazzeri, Davide,Su, Weijie,Xi, Wenjing,Zheng, Zhang,Ke, Li,Min, Peiru,Feng, Shaoqing,Zhang, Yixin,Persichetti, Paolo Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6
Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars. Through a PubMed search, we explored most of the literature that is available about the intralesional injection treatment of hypertrophic scars and keloids and highlights both current (corticosteroid, 5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments (interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were also analysed. Information was gathered about the mechanism of each injection treatment, its benefits and associated adverse reactions, and possible strategies to address adverse reactions to provide reliable guidelines for determining the optimal treatment for particular types of keloid scars. This article will benefit practitioners by outlining evidence-based treatment strategies using intralesional injections for patients with hypertrophic scars and keloids.
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Recent Developments in the Use of Intralesional Injections Keloid Treatment
Aurelia Trisliana Perdanasari,Davide Lazzeri,Weijie Su,Wenjing Xi,Zhang Zheng,Li Ke,Peiru Min,Shaoqing Feng,Yixin Zhang,Paolo Persichetti 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.6
Keloid scars are often considered aesthetically unattractive and frustrating problems thatoccur following injuries. They cause functional and cosmetic deformities, displeasure, itching,pain, and psychological stress and possibly affect joint movement. The combination of thesefactors ultimately results in a compromised quality of life and diminished functionalperformance. Various methods have been implemented to improve keloid scars using bothsurgical and non-surgical approaches. However, it has proven to be a challenge to identify auniversal treatment that can deliver optimal results for all types of scars. Through a PubMedsearch, we explored most of the literature that is available about the intralesional injectiontreatment of hypertrophic scars and keloids and highlights both current (corticosteroid,5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments(interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were alsoanalysed. Information was gathered about the mechanism of each injection treatment, itsbenefits and associated adverse reactions, and possible strategies to address adverse reactionsto provide reliable guidelines for determining the optimal treatment for particular types ofkeloid scars. This article will benefit practitioners by outlining evidence-based treatmentstrategies using intralesional injections for patients with hypertrophic scars and keloids.
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