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XiuYu Xu,Qun Zhang,Jiangping Meng,Yiping Wang,Jie Zheng,Kaifeng Wu,Xuemei Zhang,Yibing Yin 한국미생물학회 2014 The journal of microbiology Vol.52 No.4
The 23-valent polysaccharide vaccine and the 7-valent pneumococcalconjugate vaccine are licensed vaccines that protectagainst pneumococcal infections worldwide. However,the incidence of pneumococcal diseases remains high in lowincomecountries. Whole-cell vaccines with high safety andstrong immunogenicity may be a favorable choice. We previouslyobtained a capsule-deficient Streptococcus pneumoniaemutant named SPY1 derived from strain D39. As anattenuated live pneumococcal vaccine, intranasal immunizationwith SPY1 elicits broad serotype-independent protectionagainst pneumococcal infection. In this study, forsafety consideration, we inactivated SPY1 with 70% ethanoland intranasally immunized BALB/c mice with killed SPY1plus cholera toxin adjuvant for four times. Results showedthat intranasal immunization with inactivated SPY1 inducedstrong humoral and cellular immune responses. Intranasalimmunization with inactivated SPY1 plus cholera toxin adjuvantelicited effective serotype-independent protection againstthe colonization of pneumococcal strains 19F and 4 as well aslethal infection of pneumococcal serotypes 2, 3, 14, and 6B. The protection rates provided by inactivated SPY1 againstlethal pneumococcal infection were comparable to those ofcurrently used polysaccharide vaccines. In addition, vaccinespecificB-cell and T-cell immune responses mediated theprotection elicited by SPY1. In conclusion, the 70% ethanolinactivatedpneumococcal whole-cell vaccine SPY1 is a potentiallysafe and less complex vaccine strategy that offersbroad protection against S. pneumoniae.
An Accelerated Iterative Hard Thresholding Method for Matrix Completion
Juan Geng,Xingang Yang,Xiuyu Wang,Laisheng Wang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.7
The matrix completion problem is to reconstruct an unknown matrix with low-rank or approximately low-rank constraints from its partially known samples. Most methods to solve the rank minimization problem are relaxing it to the nuclear norm regularized least squares problem. Recently, there have been some simple and fast algorithms based on hard thresholding operator. In this paper, we propose an accelerated iterative hard thresholding method for matrix completion (AIHT). Then we report numerical results for solving noiseless and noisy matrix completion problems and image reconstruction. The numerical results suggest that significant improvement can be achieved by our algorithm compared to the other reported methods, especially in terms of CPU time.
SP0454, A Putative Threonine Dehydratase, Is Required For Pneumococcal Virulence In Mice
WenJuan Yan,Hong Wang,WenChun Xu,KaiFeng Wu,Run Yao,XiuYu Xu,Jie Dong,YanQing Zhang,Wen Zhong,XueMei Zhang 한국미생물학회 2012 The journal of microbiology Vol.50 No.3
Increasing pressure in antibiotic resistance and the requirement for the design of new vaccines are the objectives of clarifying the putative virulence factors in pneumococcal infection. In this study, the putative threonine dehydratase sp0454 was inactivated by erythromycin-resistance cassette replacement in Streptococcus pneumoniae CMCC 31203 strain. The sp0454 mutant was tested for cell growth, adherence, colonization, and virulence in a murine model. The Δsp0454 mutant showed decreased ability for colonization and impaired ability to adhere to A549 cells. However, the SP0454 polypeptide or its antiserum did not affect pneumococcal CMCC 31203 adhesion to A549 cells. The sp0454 deletion mutant was less virulent in a murine intranasal infection model. Real-time RT-PCR analysis revealed significant decrease of the pneumococcal surface antigen A expression in the sp0454 mutant. These results suggest that SP0454 contributes to virulence and colonization, which could be explained in part by modulating the expression of other virulence factors, such as psaA in pneumococcal infection.
Lingfang Sun,Yida Zang,Xiuyu Zhang,Guoqiang Zhu,Cheng Zhong,Chenliang Wang 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3
An adaptive dynamic surface control (DSC) scheme using event triggering mechanism and barrier Lyapunov function (BLF) to constraint state variables and solve energy saving issues is proposed for multi-agent systems (MASs). Furthermore, invented a control algorithm that uses the event-triggered mechanism for not only decrease the number of information exchanges between agents significantly but also decreased utilization of electricityand communication expenses in the control process. DSC and full-state constraints are used to solve the “complexityexplosion” problem of the traditional back-stepping method. Simulation and semi-physical experimental platformswere constructed to verify the proposed algorithm is valid.
Zhao Le,Yu Shihui,Li Junjun,Song Zichen,Wu Muying,Wang Xiuyu,Wang Xiaohu 한국물리학회 2021 Current Applied Physics Vol.31 No.-
The high sensitivity flexible capacitive pressure sensor (FCPS) manufactured in a fast and efficient way has friendly man-machine interaction function. In this paper, a high-sensitivity FCPS is developed by using a twostep template method to reproduce biomimetic microtower polydimethylsiloxane (PDMS) from the lotus leaf surface. The capacitive sensor is composed of a PDMS dielectric layer and the Cu nanowire electrodes sandwiching in the middle, with a high sensitivity of ~1.207 kPa 1, a low detection limit of less than 0.02 kPa and a fast response time of 61.6 ms. Particularly, the sensing performance can be kept basically unchanged when bent at a 5 mm radius. Moreover, the FCPS can withstand 4000 repeated tests and maintain stable performance, and the sensitivity is almost the same in the process of loading and unloading, suggesting the high robustness. These results demonstrates the FCPSs have potential applications in electronic wearables, human health monitoring and uneven surface applications.
Chuntao Yang,Jianqiang Feng,Hongzhong Ling,Meifen Zhang,Zhanli Yang,Xiuyu Wang,Fanqin Zeng,Chuhuai Wang 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.6
Hypoxia of skin is an important physiopathological process in many diseases, such as pressure ulcer, diabetic ulcer, and varicose ulcer. Although cellular injury and inflammation have been involved in hypoxia-induced dermatic injury, the underlying mechanisms remain largely unknown. This study was conducted to investigate the effects of cobalt chloride (CoCl_2), a hypoxia-mimicking agent, on human skin keratinocytes (HaCaT cells) and to explore the possible molecular mechanisms. Exposure of HaCaT cells to CoCl_2 reduced cell viability and caused overproduction of reactive oxygen species (ROS) and oversecretion of interleukin-6 (IL-6) and interleukin-8 (IL-8). Importantly, CoCl_2 exposure elicited overexpression of cyclooxygenase-2 (COX-2) and phosphorylation of nuclear factor-kappa B (NF-κB) p65 subunit. Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl2. Inhibition of NF-κB by PDTC (a selective inhibitor of NF-κB) or genetic silencing of p65 by RNAi (Si-p65), attenuated not only the cytotoxicity and secretion of IL-6 and IL-8, but also overexpression of COX-2 in CoCl2-treated HaCaT cells. Neutralizing anti-IL-6 or anti-IL-8 antibody statistically alleviated CoCl2-induced cytotoxicity in HaCaT cells. N-acetyl-L-cysteine (NAC), a well characterized ROS scavenger, obviously suppressed CoCl_2-induced cytotoxicity in HaCaT cells, as well as secretion of IL-6 and IL-8. Additionally, NAC also repressed overexpression of COX-2 and phosphorylation of NF-κB p65 subunit induced by CoCl_2 in HaCaT cells. In conclusion, our results demonstrated that oxidative stress mediates chemical hypoxia-induced injur and inflammatory response through activation of NF-κB–COX-2 pathway in HaCaT cells.