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Rongliang Wang APEC국제교육협력원 2005 Asia-Pacific Cybereducation Journal Vol.1 No.2
China has been moving rapidly to improve the use of information technology in elementary and secondary schools, progressing in stages from offering basic computer programming courses to creating networked schools with information technology integrated into the whole curriculum. By 2003, in the developed regions of the country, 70 percent of teachers applied information technology to their classes often. In the Tenth Five Year Plan (2001 - 2005), the Chinese government gave priority to the construction of information technology infrastructure. By 2003 the ratio of elementary school students to computers was 12:1 in the most developed regions and 373:1 in the least developed. At the high school level the range was from 8:1 to 18:1. One goal is to equalize educational opportunities across the geographic regions, which now vary greatly As part of this education improvement initiative, the central government will undertake a number of programs, including an ICT development project in village schools, aimed at improving staff development, school management, and instructional quality and efficiency. According to the new teacher training plan, normal universities will make full use of face-to-face education and distance education to lay the groundwork for improved instructional resources and form an instructional network for village and city teachers. Those regions which have been well equipped with computers and school networks will develop network training and TV training. The purpose of these efforts is to effect modernization in education, meaning the improvement of educational efficiency and effectiveness and the promotion of more learner-centered instruction.
An Xueying,Wang Rongliang,Lv Zhongyang,Wu Wenshu,Sun Ziying,Wu Rui,Yan Wenjin,Jiang Qing,Xu Xingquan 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes. Mechanistically, the m6A modification and relative downstream targets in osteoarthritic cartilage were assessed by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing, which indicated that the expression of frizzled-related protein (FRZB), a secreted Wnt antagonist, was abnormally decreased and accompanied by high m6A modification in osteoarthritic cartilage. In vitro dysregulated WTAP had positive effects on β-catenin expression by targeting FRZB, which finally contributed to the cartilage injury phenotype in chondrocytes. Intra-articular injection of adeno-associated virus-WTAP alleviated OA progression in a mouse model, while this protective effect could be reversed by the application of a Wnt/β-catenin activator. In summary, this study revealed that WTAP-dependent RNA m6A modification contributed to Wnt/β-catenin pathway activation and OA progression through post-transcriptional regulation of FRZB mRNA, thus providing a potentially effective therapeutic strategy for OA treatment.