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Yin, Q.Q.,Chang, J.,Zuo, R.Y.,Chen, L.Y.,Chen, Q.X.,Wei, X.Y.,Guan, Q.F.,Sun, J.W.,Zheng, Q.H.,Yang, X.,Ren, G.Z. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.2
In order to improve the availability of phytase and probiotics together, a phytase gene from Aspergillus ficuum has been expressed in Lactobacillus. In this study, the transformed Lactobacillus with phytase gene was fed to pigs to determine its effect on pig production, feed conversion and gut microbes. Forty eight, 60-day-old, castrated pigs (Duroc${\times}$Landrace${\times}$Pietrain) were assigned to 6 groups, 8 pigs for each group. Group 1 was the control, group 2 was added with chlortetracycline (500 mg/kg), group 3 was added with the transformed Lactobacillus (500 mg/kg) with 20% (w/w) of calcium monohydrogen phosphate (CMP, $CaHPO_{4}$) removed, group 4 was added with the natural Lactobacillus (500 mg/kg) with 20% (w/w) of CMP removed, group 5 was added with the transformed Lactobacillus (500 mg/kg) with 40% (w/w) of CMP removed, group 6 was added with phytase (500 mg/kg) with 40% (w/w) of CMP removed. The results showed: i) the average daily gain (ADG) was improved in groups 2, 3 and 4 (p<0.05); ii) the diarrhea rates in the groups added with Lactobacillus were lower than in the other groups (p<0.05), in which the transformed Lactobacillus had more effect on reducing digestive disease; iii) the transformed Lactobacillus was most effective in improving the digestibilities of crude protein (CP), calcium (Ca), phosphorus (P), compared with the other groups (p<0.05); iv) Lactobacillus could increase lactic acid bacterium number and ammonia concentrations, and decrease pH values and E. coli number in pig feces (p<0.05); v) the phytase activity in the feces of pigs fed with the transformed Lactobacillus was 133.32 U/g, which was higher than in group 4 (9.58 U/g, p<0.05), and was almost the same as group 6 (135.94 U/g); vi) the transformed Lactobacillus could increase serum concentrations of IgA, triglyceride, and glutamic oxaloacetic transaminase activity (p<0.05), and had no significant effect on other serum indexes (p>0.05).
Loss-Separation Study on Silica-insulated Gas-atomized Fe-Si-Al Soft Magnetic Composites
T. T. Xu,B. W. Zhang,Z. Shi,W. W. Guan,K. Wan,X. Y. Shi,W. Liu,H. L. Su,Z. Q. Zou,Y. W. Du 한국자기학회 2020 Journal of Magnetics Vol.25 No.2
Fe-Si-Al soft magnetic composites were composed of gas-atomized Fe-9.6wt.%Si-5.4wt.%Al alloy powders insulated with silica nanoparticles. The influence of silica insulation content on the core’s magnetic properties was studied. It was found that increasing the silica mass ratio deteriorated the effective permeability and core loss in the frequency range of 40-120 kHz, while improved the quality factor at 100 kHz and DC-bias performance. The effective demagnetizing field reflected by density and the core’s volume resistivity may cause the variations of these magnetic parameters. Loss separation fitting was performed using the Bertotti formula, indicating that silica insulation increased the hysteresis loss and reduced the eddy-current loss. The hysteresis loss took over at the frequency lower than 120 kHz in this work. With increasing the frequency, the eddy-current loss grew more quickly than the hysteresis loss. Therefore, different methods should be adopted to reduce the core loss according to the core’s application frequency.
Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP
Hong, Audrey W,Meng, Zhipeng,Yuan, Hai‐,Xin,Plouffe, Steven W,Moon, Sungho,Kim, Wantae,Jho, Eek‐,hoon,Guan, Kun‐,Liang EMBO 2017 EMBO reports Vol.18 No.1
<P>YAP is the major downstream effector of the Hippo pathway, which controls cell growth, tissue homeostasis, and organ size. Aberrant YAP activation, resulting from dysregulation of the Hippo pathway, is frequently observed in human cancers. YAP is a transcription co-activator, and the key mechanism of YAP regulation is its nuclear and cytoplasmic translocation. The Hippo pathway component, LATS, inhibits YAP by phosphorylating YAP at Ser127, leading to 14-3-3 binding and cytoplasmic retention of YAP. Here, we report that osmotic stress stimulates transient YAP nuclear localization and increases YAP activity even when YAP Ser127 is phosphorylated. Osmotic stress acts via the NLK kinase to induce YAP Ser128 phosphorylation. Phosphorylation of YAP at Ser128 interferes with its ability to bind to 14-3-3, resulting in YAP nuclear accumulation and induction of downstream target gene expression. This osmotic stress-induced YAP activation enhances cellular stress adaptation. Our findings reveal a critical role for NLK-mediated Ser128 phosphorylation in YAP regulation and a crosstalk between osmotic stress and the Hippo pathway.</P>
Guan, X.Y.,Leem, J.W.,Lee, S.H.,Jang, H.J.,Kim, J.H.,Hann, S.,Yu, J.S. Elsevier 2016 CURRENT APPLIED PHYSICS Vol.16 No.2
<P>The device performance improvement of ridge waveguide (RWG) laser diodes (LDs), operating at a wavelength (lambda) of similar to 960 nm, with a metal-dielectric high-reflection (HR) mirror consisting of Au/Ti-SiO2 layers on the back facet was demonstrated. To determine the optimum thickness of each layer, optical reflection calculations were performed using a rigorous coupled-wave analysis method, which leads to the resultant Au (80 nm)/Ti (5 nm)-SiO2 (164 nm) layers. The layers exhibited a broad high reflection band of >91% over a wavelength range of 920-1000 nm, indicating the reflectivity of similar to 91.2% at lambda similar to 960 nm. For 2 mm-cavity RWG LDs with the Au/Ti-SiO2 HR mirror, an enhanced maximum output power (P-max) of 499.3 mW at an injection current of 3000 mA and a decreased threshold current (Ith) of 516 mA (i.e., P-max = 259.4 mW and Ith = 650 mA for the uncoated LDs) were obtained, showing an increased slope efficiency percentage of 82%. The external differential quantum efficiency was also increased from similar to 17.1 to similar to 31.1%. Also, the full widths at half maximum values of beam divergences of the device were 38 degrees (vertical direction) and 4 degrees (horizontal direction). (C) 2015 Elsevier B.V. All rights reserved.</P>
Shang-Guan, Keke,Wang, Min,Htwe, Nang Myint Phyu Sin,Li, Ping,Li, Yaoshen,Qi, Fan,Zhang, Dawei,Cao, Min,Kim, Chanhong,Weng, Haiyong,Cen, Haiyan,Black, Ian M.,Azadi, Parastoo,Carlson, Russell W.,Stacey American Society of Plant Biologists 2018 Plant Physiology Vol.176 No.3
<P>Lipopolysaccharides induce a long-lasting burst of reactive oxygen species that is largely associated with chloroplasts.</P><P>Lipopolysaccharides (LPS) are major components of the outer membrane of gram-negative bacteria and are an important microbe-associated molecular pattern (MAMP) that triggers immune responses in plants and animals. A previous genetic screen in Arabidopsis (<I>Arabidopsis thaliana</I>) identified LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION (LORE), a B-type lectin <I>S</I>-domain receptor kinase, as a sensor of LPS. However, the LPS-activated LORE signaling pathway and associated immune responses remain largely unknown. In this study, we found that LPS trigger biphasic production of reactive oxygen species (ROS) in Arabidopsis. The first transient ROS burst was similar to that induced by another MAMP, flagellin, whereas the second long-lasting burst was induced only by LPS. The LPS-triggered second ROS burst was found to be conserved in a variety of plant species. Microscopic observation of the generation of ROS revealed that the LPS-triggered second ROS burst was largely associated with chloroplasts, and functional chloroplasts were indispensable for this response. The lipid A moiety, the most conserved portion of LPS, appears to be responsible for the second ROS burst. Surprisingly, the LPS- and lipid A-triggered second ROS burst was only partially dependent on LORE. Together, our findings provide insight on the LPS-triggered ROS production and the associated signaling pathway.</P>