Assessment of swallowing and masticatory performance in obturator wearers: a clinical study

Vero, Nungotso,Mishra, Niraj,Singh, Balendra Pratap,Singh, Kamleshwar,Jurel, Sunit Kumar,Kumar, Vijay The Korean Academy of Prosthodonitics 2015 The Journal of Advanced Prosthodontics Vol.7 No.1

PURPOSE. To assess function by identifying changes in swallowing and masticatory performance in maxillary obturator prosthesis wearers. MATERIALS AND METHODS. Sixty subjects were recruited for the study, of which 20 were obturator wearers, 20 were completely dentulous and 20 had removable partial/complete dentures with similar Eichner's Index. Swallowing ability was evaluated with and without obturator using the "Water Drinking Test"; Masticatory performance was evaluated with the Sieve test; and maximum occlusal force was recorded with the help of a digital bite sensor. The data was analyzed using the Statistical Package for Social Science version 15.0 with a confidence level at 95%. RESULTS. Profile, behavior of drinking and time taken to drink were significantly improved (P<.001) in subjects after wearing obturator. Masticatory performance was not significantly different (P=.252) in obturator wearer when compared with dentulous or removable partial/complete denture wearer, but significantly (P<.001) high inter group difference in maximum occlusal force existed. Correlation between masticatory performance and maximum occlusal force was not significant (P=.124). CONCLUSION. Swallowing ability was significantly improved after wearing obturator but masticatory performance was not significantly different from those having similar occlusal support zone in their dentition.

Influence of deposition conditions on the growth of micron-thick highly c-axis textured superconducting GdBa₂Cu₃O_7-δ films on SrTiO₃ (100)

De Vero, Jeffrey C.,Lee, Doopyo,Shin, Hyeonseop,Namuco, Shielo B.,Hwang, Inwoong,Sarmago, Rolang V.,Song, Jong Hyun American Vacuum Society 2018 Journal of vacuum science & technology. an officia Vol.36 No.3

Growth and Magnetotransport Characteristics of AIrO₃ (A=Ca, Ba, Sr) Incorporated Bi₂Sr₂ CaCu₂O <tex> \(_{{\textbf {8}\boldsymbol {+\delta }}}\)</tex> Superconducting Films

Centeno de Vero, Jeffrey,Inwoong Hwang,Santiago, Alvin L.,Doopyo Lee,Jungwon Chang,Jinhee Kim,Sarmago, Roland V.,Jong Hyun Song IEEE 2014 IEEE transactions on magnetics Vol.50 No.11

<P>We successfully grew AIrO<SUB>3</SUB> (A = Ca, Ba Sr) incorporated Bi<SUB>2</SUB> Sr<SUB>2</SUB> CaCu<SUB>2</SUB>O<SUB>8+δ</SUB> (BSCCO) films using pulsed laser deposition technique with post-growth ex situ treatment. The incorporation was accomplished by initially growing AIrO<SUB>3</SUB> iridate nanoparticles on top of a single crystal MgO (100) substrate followed by a BSCCO layer. The composite film was then partial melted at 890 °C for 15 min and annealed at 850 °C for 5 h in ambient air. In this way, we controlled the type of iridate nanoparticles, which were embedded inside the superconducting BSCCO matrix. We observed that the superconducting transition temperature T<SUB>c-zero</SUB>, activation energy U<SUB>o</SUB>, and magnetoresistance can be tuned depending on the type of iridate incorporation.</P>

Capacities, Processes, and Feedbacks: The Complex Dynamics of Development

Gabriel Yoguel,Verónica Robert 서울대학교 경제연구소 2010 Seoul journal of economics Vol.23 No.2

The theory of complex systems applied to the evolutionary economics allows innovation to be considered not only the result of the intentional action of individual agent, but as an endogenous property of system dynamics. In this sense, innovation constitutes an emergent property of the system because it is not entirely determined on micro or macro levels, but is a result of continuous interaction between the two. At micro level the paper assumes that economic agents are endowed with intentionality in their adaptive or creative reactions that explains specific patterns of capacities and connectivity development. At macro level, processes of creative destruction, appropriation and structural change describe the evolution of the whole system. These dynamics tend to consolidate institutional frameworks that could be adverse or beneficial to innovation and that would reinforce divergent development paths. The feedbacks between micro and macro levels explain why the initial differences in development levels tend to increase between developed and developing countries.

Safety Assessment and Botanical Standardization of an Edible Species from South America

Giseli Karenina Traesel,Camila Dias Machado,Cleide Adriane Signor Tirloni,Jacqueline Vergutz Menetrier,Francislaine Aparecida dos Reis Lı´vero,Emerson Luiz Botelho Lourenco,Silvia Aparecida Oesterreic 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.5

Tropaeolum majus L. (Tropaeolaceae), commonly known as nasturtium, is an important edible plant native to the Andean States and widely disseminated throughout South America. Despite the use of this species is quite widespread, there are no minimum quality control standards or data on its genotoxicity. So, the aim of this study was to present a detailed anatomical and histochemical study for Tropaeolum majus and provide genotoxicity parameters of a preparation routinely used in South American countries. First, three different Tropaeolum majus aqueous extracts (TMAEs) at concentrations of 1.5%, 7%, and 15% were prepared according to the popular use. Then, genetic toxicity of TMAE was evaluated on bacterial reverse mutation, genomic lesions, and micronucleus formation in male rats. Furthermore, a detailed anatomical and histochemical study of the leaves and stems of Tropaeolum majus were performed. No revertant colonies were found in any bacterial cultures examined. In the comet assay, TMAE showed no significant DNA damage in all tested doses. Micronucleus assay showed no significant increases in the frequency of inducing micronuclei in any dose examined. Light and electron microscope images of cross-section of leaves and stems from Tropaeolum majus revealed useful diagnostic features. The presented data showed significant safety parameters for the use of TMAE and provided important data for the quality control of this plant species.

Assessment of swallowing and masticatory performance in obturator wearers: a clinical study

Kamleshwar Singh,Sunit Kumar Jurel,Vijay Kumar,Balendra Pratap Singh,Niraj Mishra,Nungotso Vero 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.1

PURPOSE To assess function by identifying changes in swallowing and masticatory performance in maxillary obturator prosthesis wearers. MATERIALS AND METHODS Sixty subjects were recruited for the study, of which 20 were obturator wearers, 20 were completely dentulous and 20 had removable partial/complete dentures with similar Eichner's Index. Swallowing ability was evaluated with and without obturator using the "Water Drinking Test"; Masticatory performance was evaluated with the Sieve test; and maximum occlusal force was recorded with the help of a digital bite sensor. The data was analyzed using the Statistical Package for Social Science version 15.0 with a confidence level at 95%. RESULTS Profile, behavior of drinking and time taken to drink were significantly improved (P<.001) in subjects after wearing obturator. Masticatory performance was not significantly different (P=.252) in obturator wearer when compared with dentulous or removable partial/complete denture wearer, but significantly (P<.001) high inter group difference in maximum occlusal force existed. Correlation between masticatory performance and maximum occlusal force was not significant (P=.124). CONCLUSION Swallowing ability was significantly improved after wearing obturator but masticatory performance was not significantly different from those having similar occlusal support zone in their dentition.

Natural Products as Modulators of Mitochondrial Dysfunctions Associated with Cardiovascular Diseases: Advances and Opportunities

Thaise Boeing,Francislaine Aparecida dos Reis Lívero,Priscila de Souza,Danielle Ayr Tavares de Almeida,Guilherme Donadel,Emerson Luiz Botelho Lourenço,Arquimedes Gasparotto Junior 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.5

The mitochondria have an important role in modulating cell cycle progression, cell survival, and apoptosis. In the adult heart, the cardiac mitochondria have a unique spatial arrangement and occupy nearly one-third the volume of a cardiomyocyte, being highly efficient for converting the products of glucose or fatty acid metabolism into adenosine triphosphate (ATP). In cardiomyocytes, the decline of mitochondrial function reduces ATP generation and increases the production of reactive oxygen species, which generates impaired heart function. This is because mitochondria play a key role in maintaining cytosolic calcium concentration and modulation of muscle contraction, as ATP is required to dissociate actin from myosin. Beyond that, mitochondria have a significant role in cardiomyocyte apoptosis because it is evident that patients who have cardiovascular diseases (CVDs) have increased mitochondrial DNA damage to the heart and aorta. Many studies have shown that natural products have mitochondria-modulating effects in cardiac diseases, determining them as potential candidates for new medicines. This review outlines the leading plant secondary metabolites and natural compounds derived from microorganisms as modulators of mitochondrial dysfunctions associated with CVDs.

Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19

da Silva da Costa Felipe Allan,Soares Murilo Racy,Malagutti-Ferreira Maria José,da Silva Gustavo Ratti,Lívero Francislaine Aparecida dos Reis,Ribeiro-Paes João Tadeu 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.5

Background: Chronic respiratory diseases (CRD) are a major public health problem worldwide. In the current epidemiological context, CRD have received much interest when considering their correlation with greater susceptibility to SARS-Cov-2 and severe disease (COVID-19). Increasingly more studies have investigated pathophysiological interactions between CRD and COVID-19. Area covered: Animal experimentation has decisively contributed to advancing our knowledge of CRD. Considering the increase in ethical restrictions in animal experimentation, researchers must focus on new experimental alternatives. Two-dimensional (2D) cell cultures have complemented animal models and significantly contributed to advancing research in the life sciences. However, 2D cell cultures have several limitations in studies of cellular interactions. Three-dimensional (3D) cell cultures represent a new and robust platform for studying complex biological processes and are a promising alternative in regenerative and translational medicine. Expert opinion: Three-dimensional cell cultures are obtained by combining several types of cells in integrated and self-organized systems in a 3D structure. These 3D cell culture systems represent an efficient methodological approach in studies of pathophysiology and lung therapy. More recently, complex 3D culture systems, such as lung-on-a-chip, seek to mimic the physiology of a lung in vivo through a microsystem that simulates alveolar-capillary interactions and exposure to air. The present review introduces and discusses 3D lung cultures as robust platforms for studies of the pathophysiology of CRD and COVID-19 and the mechanisms that underlie interactions between CRD and COVID-19. Background: Chronic respiratory diseases (CRD) are a major public health problem worldwide. In the current epidemiological context, CRD have received much interest when considering their correlation with greater susceptibility to SARS-Cov-2 and severe disease (COVID-19). Increasingly more studies have investigated pathophysiological interactions between CRD and COVID-19. Area covered: Animal experimentation has decisively contributed to advancing our knowledge of CRD. Considering the increase in ethical restrictions in animal experimentation, researchers must focus on new experimental alternatives. Two-dimensional (2D) cell cultures have complemented animal models and significantly contributed to advancing research in the life sciences. However, 2D cell cultures have several limitations in studies of cellular interactions. Three-dimensional (3D) cell cultures represent a new and robust platform for studying complex biological processes and are a promising alternative in regenerative and translational medicine. Expert opinion: Three-dimensional cell cultures are obtained by combining several types of cells in integrated and self-organized systems in a 3D structure. These 3D cell culture systems represent an efficient methodological approach in studies of pathophysiology and lung therapy. More recently, complex 3D culture systems, such as lung-on-a-chip, seek to mimic the physiology of a lung in vivo through a microsystem that simulates alveolar-capillary interactions and exposure to air. The present review introduces and discusses 3D lung cultures as robust platforms for studies of the pathophysiology of CRD and COVID-19 and the mechanisms that underlie interactions between CRD and COVID-19.