http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Verghese, Philip B. (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes
Chung, Won-Suk,Verghese, Philip B.,Chakraborty, Chandrani,Joung, Julia,Hyman, Bradley T.,Ulrich, Jason D.,Holtzman, David M.,Barres, Ben A. National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.36
<P>The strongest genetic risk factor influencing susceptibility to lateonset Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans, E2, E3, and E4. The presence of two copies of the E4 allele increases risk by similar to 12-fold whereas E2 allele is associated with an similar to twofold decreased risk for AD. These data put APOE central to AD pathophysiology, but it is not yet clear how APOE alleles modify AD risk. Recently we found that astrocytes, a major central nervous system cell type that produces APOE, are highly phagocytic and participate in normal synapse pruning and turnover. Here, we report a novel role for APOE in controlling the phagocytic capacity of astrocytes that is highly dependent on APOE isoform. APOE2 enhances the rate of phagocytosis of synapses by astrocytes, whereas APO4 decreases it. We also found that the amount of C1q protein accumulation in hippocampus, which may represent the accumulation of senescent synapses with enhanced vulnerability to complement-mediated degeneration, is highly dependent on APOE alleles: C1q accumulation was significantly reduced in APOE2 knock-in (KI) animals and was significantly increased in APOE4 KI animals compared with APOE3 KI animals. These studies reveal a novel allele-dependent role for APOE in regulating the rate of synapse pruning by astrocytes. They also suggest the hypothesis that AD susceptibility of APOE4 may originate in part from defective phagocytic capacity of astrocytes which accelerates the rate of accumulation of C1q-coated senescent synapses, enhancing synaptic vulnerability to classical-complement-cascade mediated neurodegeneration.</P>
-
Role of colour and volatile in foraging behaviour of honeybee Apis cerana on Jacquemontia pentanthos
Anitha Annamma Abraham,Abraham Verghese,Subramanyam Muthangi 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.4
Floral visual and olfactory cues guide the insect visitors to the source of reward. This work addresses one such interaction between honeybee Apis cerana and a garden climber Jacquemontia pentanthos. Field studies have indicated that A. cerana showed preference to J. pentanthos over the other flowering plants during its visits for foraging. The objectives of the work is to understand the role of colour and scent in the attraction of Apis cerana to the host plant. Bioassays performed emphasized the involvement of colour and volatiles for the visits of A. cerana. Petals show high reflectance to ultraviolet light with ultraviolet absorbing regions in the centre which serve as a nectar guide. Gas chromatography linked electroanntenogram detector (GC-EAD) showed antennal response to the floral volatile of J. pentanthos identified as sesquiterpene β-caryophyllene. Behavioural studies have shown similar preference to β- caryophyllene as that of α-humulene. Our studies suggest an interplay of colour and volatiles cues for A. cerana visitation to Jacquemontia flowers and these findings are further supported by behavioural studies on.
-
Janak Khatiwada,Martha Verghese,Shurrita Davis,Leonard L. Williams 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.11
Experimental as well as epidemiologic studies in human populations provide evidence that consumption of phytochemicals reduces the incidence of degenerative diseases. Green tea (GT) catechins are known for their antioxidative potential. Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits. This experiment was designed to investigate the inhibitory effects of combinations of 1% and 2% GT, PA, and inositol (I) in reducing the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. After an acclimatization period of 1 week, nine groups of rats (15 rats per group) were initially assigned to consume AIN 93 G diet and later AIN 93 M diet after 20 weeks of age. Treatments were given in drinking water. All rats received azoxymethane injections (16 mg/kg of body weight) subcutaneously at 7 and 8 weeks of age. Rats were killed at 45 weeks of age by CO₂euthanasia. Tumor incidence (93.76%) and the number of tumors per tumor-bearing rat ratio (2.25) were significantly (P<.05) higher in the control group compared with treatment groups. Glutathione S-transferase activity was significantly (P<.05) higher in rats fed combinations of 2% GT+PA+I and GT+PA (33.25±1.23 and 29.83±1.10 μmol/mL, respectively) compared with other groups. These findings suggest that the synergistic effect of the 2% level of GT, PA, and I may reduce the incidence of colon tumors and therefore have potential as a chemopreventive agent.
-
Zeev Meiner,Emmeline Ayers,Joe Verghese 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.1
Changes in gait, especially decreased gait velocity, may be a harbinger of cognitive decline in aging. Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome combining slow gait and cognitive complaints, is a powerful clinical tool used to identify older adults at a high risk of developing dementia. The mean prevalence of MCR worldwide, including in a Korean cohort, was around 10%. The reported risk factors for incident MCR include older age, low education, cardiovascular disease, obesity, physical inactivity, and depression. In addition to dementia, MCR is also a risk factor for other age-related adverse conditions such as falls, disability, frailty, and mortality. MCR has advantages over other pre-dementia syndromes in being much simpler to implement and requires fewer resources. Identification of mechanisms responsible for MCR may help in developing interventions to reduce the growing burden of dementia and disability worldwide.
-
Attention to Multiple Objects Facilitates Their Integration in Prefrontal and Parietal Cortex
Kim, Yee-Joon,Tsai, Jeffrey J.,Ojemann, Jeffrey,Verghese, Preeti Society for Neuroscience 2017 The Journal of neuroscience Vol.37 No.19
<P>Selective attention is known to interact with perceptual organization. In visual scenes, individual objects that are distinct and discriminable may occur on their own, or in groups such as a stack of books. The main objective of this study is to probe the neural interaction that occurs between individual objects when attention is directed toward one or more objects. Here we record steady-state visual evoked potentials via electrocorticography to directly assess the responses to individual stimuli and to their interaction. When human participants attend to two adjacent stimuli, prefrontal and parietal cortex shows a selective enhancement of only the neural interaction between stimuli, but not the responses to individual stimuli. When only one stimulus is attended, the neural response to that stimulus is selectively enhanced in prefrontal and parietal cortex. In contrast, early visual areas generally manifest responses to individual stimuli and to their interaction regardless of attentional task, although a subset of the responses is modulated similarly to prefrontal and parietal cortex. Thus, the neural representation of the visual scene as one progresses up the cortical hierarchy becomes more highly task-specific and represents either individual stimuli or their interaction, depending on the behavioral goal. Attention to multiple objects facilitates an integration of objects akin to perceptual grouping.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
