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- 저자 : Valsala, PA (검색결과 5 건)
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Reshma Lali Raveendran,Manjusha Valsala,Thayyath Sreenivasan Anirudhan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Injectable hydrogels with macroscopic ordering have gained special attention in drug delivery due totheir excellent biocompatibility and minimally invasive surgical procedure. Nanosilver embeddedSchiff base hydrogel from biopolymers alginate and chitosan was developed and demonstrated its applicationin the injectable delivery of anticancer drug Dox.HCl. The ordered hydrogel structure was evidencedby FT-IR, DLS, XRD and Rheology. The self-assembled morphology of nanosilver- Schiff basehydrogels was studied by microscopic techniques such as SEM, TEM and AFM. The pH dependent anticanceractivity of the hydrogel was demonstrated by invitro drug release studies at pH 5.5 and 86.56 %release was obtained for 100 mgL-1 of Dox.HCl loaded hydrogel at 72 hours. The antibacterial activityattained from nanosilver can be assessed by Agar well diffusion assay and minimum inhibitory concentrationand minimum biocidal concentrations were determined as 62.5 lL/mL and 125 lL/mL, respectively. The invitro cell viability studies were done against skin cancer cell B16 by MTT assay whichshows 34.82 % of toxicity towards B16 cancer cells and the cell death was further confirmed byApoptosis assay and flow cytometry. The developed macroscopically ordered liquid crystalline hydrogelcan be act as a versatile platform for injectable drug delivery system.
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Sundaramoorthy, Rajiv,Srinivasan, Vasanth,Gujar, Jidnyasa,Sen, Ayantika,Sekar, Nishu,Abilash, Valsala Gopalakrishnan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Beedi rollers are exposed to unburnt tobacco dust through cutaneous and pharyngeal route and it is extremely harmful to the body since it is carcinogenic in nature and can cause cancer during long exposure. This indicates that occupational exposure to tobacco imposes considerable genotoxicity among beedi workers. Materials and Methods: In the present study, 27 beedi workers and age and sex matched controls were enrolled for clinical, cytogenetics and molecular analysis. Clinical features were recorded. The workers were in the age group of 28-67 years and were workers exposure from 8-60 years. Blood samples were collected from workers and control subjects and lymphocyte cultures were carried out by using standard technique, slides were prepared and 50 metaphases were scored for each sample to find the chromosomal abnormalities. For molecular analysis the genomic DNA was extracted from peripheral blood, to screen the variations in gene, the exon 1 of CYP1A1 gene was amplified by polymerase chain reaction (PCR) and then screened with Single Strand Conformation Polymorphism (SSCP) analysis. Results: A statistically significant increase was observed in the frequencies of chromosomal aberrations in exposed groups when compared to the respective controls and variations observed in Exon 1 of CYP1A1(Cytochrome P450, family 1, subfamily A, polypeptide 1) gene. Conclusions: This study shows that, the toxicants present in the beedi that enter into human body causes disturbance to normal state and behavior of the chromosomes which results in reshuffling of hereditary material causing chromosomal aberrations and genomic variations.
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Roy, Nabarun,Davis, Sangeetha,Narayanankutty, Arunaksharan,Nazeem, PA,Babu, TD,Abida, PS,Valsala, PA,Raghavamenon, Achuthan C Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: Breast cancer (BC) is a serious lifestyle disease. There are several prognostic biomarkers like nuclear receptors whose over-expression is associated with BC characteristics. These biomarkers can be blocked by compounds with anti-cancer potential but selection must be made on the basis of no adverse side effects. This study is focused on finding of compounds from a plant source garlic. Materials and Methods: Twenty compounds from garlic and five targets considered involved in BC were retrieved from Pubchem database and Protein Data Bank respectively. They were docked using Accelrys Discovery Studio (DS) 4.0. The compounds which showed interaction were checked for drug likeliness. Results: Docking studies and ADMET evaluation revealed twelve compounds to be active against the targets. All the compounds displayed highly negative dock scores which indicated good interactions. Conclusions: The results of this study should help researchers and scientists in the pharmaceutical field to identify drugs based on garlic.
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Multi-Parameter Approach for Evaluation of Genomic Instability in the Polycystic Ovary Syndrome
Sekar, Nishu,Nair, Manju,Francis, Glory,Kongath, Parvathy Raj,Babu, Sandhya,Raja, Sudhakaran,Gopalakrishnan, Abilash Valsala Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: The polycystic ovary syndrome (PCOS), characterized by hyperandrogenism and chronic anovulation, is a common endocrine disorder in women. PCOS, which is associated with polycystic ovaries, hirsutism, obesity and insulin resistance, is a leading cause of female infertility. In this condition there is an imbalance in female sex hormones. All the sequelae symptoms of PCOS gradually lead to cancer in the course of time. It is heterogeneous disorder of unknown etiology so it is essential to find the exact cause. Materials and Methods: In this study both invasive and non-invasive techniques were employed to establish the etiology. Diagnosis was based on Rotterdam criteria (hyperandrogenism, ovulatory dysfunction, PCOM) and multiparameters using buccal samples and dermatoglypic analysis and cytogenetic study for 10 cases and four age and sex matched controls. Results: In clinical analysis we have observed the mean value of total testosterone level was 23.6nmol/L, total hirsutism score was from 12-24, facial acne was found in in 70% patients with 7-12 subcapsular follicular cysts, each measuring 2-8 mm in diameter. In dermatoglypic analysis we observed increases in mean value ($45.9^{\circ}$) of ATD angle when compared with control group and also found increased frequency (38%) of Ulnar loops on both fingers (UU), (18%) whorls on the right finger and Ulnar loop on left finger (WU) and (16%) arches on right and left fingers (AA) were observed in PCOS patients when compared with control subjects. Features which could be applied as markers for PCOS patients are the presence of Ulnar loops in middle and little fingers of right and left hand. The buccal micronucleus cytome assay in exfoliated buccal cells, we found decrease in frequency of micronuclei and significant increases in frequency of karyolysed nuclei in polycystic ovarian syndrome patients. Chromosome aberration analysis revealed a significant increase in frequency of chromosome aberrations (CAs) in PCOS patients when compared with controls. Conclusions: From this present work it can be concluded that non-invasive technique like dermatoglypics analysis and buccal micronucleus cytome assays with exfoliated buccal cell can also be effective biomarkers for PCOS, along with increased CAs in lymphocytes as a sign of genetic instability. There is a hypothesis that micronuclei and chromosomal aberrations could have a predictive value for cancer. From this present work it can be concluded to some extent that non-invasive technique like dermatoglypics and buccal cell analysis can also be effective for diagnosis.
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