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Valizadeh Bita,Afrazeh Zahra,Sendi Jalal Jalali 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
The Helicoverpa armigera nucleopolyhedrovirus (HearNPV) is the active ingrediant biopesticide used to manage larvae. However, the effectiveness of HearNPV is limited by ultraviolet (UV) radiation. This study was conducted to develop a new formulation of HearNPV that is more tolerant to UV without compromising its efficiency. A microencapsulated formulation of HearNPV was increase its resistance to UV. For this, the virus was produced using cell lines established from H. armigera hemocytes in two media (Grace’s and EX-CELL 420). The micro encapsulated formulation consisted of two different formulas. Formula A included cotton seed kernel extract, boric acid, glycerol, egg white, Bran, and sugar and Formula B included sodium alginate, gelatin, molasses and starch. The results showed that the microencapsulated formulation B exhibited higher photostability with an efficacy (84. 7 ± 4 %) and an original activity remaining (OAR) of 91.31 ± 2. 9 % after 72 h of exposure to UV by 385 nm. The average percentage of OAR in control HearNPV and formulation A was 10. 22 ± 1. 8 % and 45. 33 ± 3. 6 % respectively, after 72 h of UV exposure, with no significant statistical differences between control and formulation A. The evaluated microencapsulation mixture B had good potential to protect HearNPVs micro particles against UV inactivation. Furthermore, in EX-CELL 420 medium, virulence of the HearNPV close to that of OBs grow in the insect, with a LC 50 of 6.58 × 10 5 OBs/mL. Therefore, the current study aimed to establish a novel and more stable pathogenic formulation in order to manage the cotton bollworm in the field.
Valizadeh, Armita,Ahmadzadeh, Ahmad,Teimoori, Ali,Khodadadi, Ali,Saki, Ghasem Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) is an antitumor candidate in cancer therapy. This study focused on effects of TRAIL, as a proapototic ligand that causes apoptosis, in B-CELL chronic lymphocytic leukemia cells (B-CLL). Materials and Methods: A population of HEK 293 cells was transducted by lentivirus that these achieved ability for producing the TRAIL protein and then HEK 293 cells transducted were placed in the vicinity of CLL cells. After 24 hours of co-culture, apoptosis of CLL cells was assessed by annexin V staining. Results: The amount of Apoptosis was examined separately in four groups: 293 HEK TRAIL ($16.17{\pm}1.04%$); 293 HEK GFP ($2.7{\pm}0.57%$); WT 293 HEK ($2{\pm}2.6%$); and CLL cells ($0.01{\pm}0.01%$). Among the groups studied, the maximum amount of apoptosis was in the group that the vector encoding TRAIL was transducted. In this group, the mean level of soluble TRAIL in the culture medium was 253pg/ml; also flow cytometry analyzes showed that proapotosis in this group was $32.8{\pm}1.6%$, which was higher than the other groups. Conclusions: In this study, we have demonstrated that TNF secreted from HEK 293 cells are effective in death of CLL cells.
Valizadeh, R.,Behgar, M.,Mirzaee, M.,Naserian, A.A.,Vakili, A.R.,Ghovvati, S. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.10
This study was conducted to evaluate the effects of the particle size (PS) of alfalfa hay (AH) and soybean hull (SH) on milk production of dairy cows and the population of major cellulolytic bacteria in the rumen. Eight lactating Holstein cows, averaging $590{\pm}33\;kg$ BW and $47{\pm}13$ days in milk (DIM), were assigned in a $4{\times}4$ Latin square design to a $2{\times}2$ factorial arrangement of treatments: alfalfa hay particle size (fine vs. coarse) combined with soy hull (zero or substituted as 50% of AH). The cows were fed diets formulated according to NRC (2001). Physically effective factor (pef) and physically effective fiber (peNDF) contents of diets increased by increasing AH particle size and inclusion of SH in the diets (p<0.01). Dry matter intake was not significantly affected by treatments but intake of peNDF was increased marginally by increasing the PS of AH (p = 0.08) and by SH inclusion (p<0.01) in the diets. Milk production was increased by feeding diets containing SH (p = 0.04), but it was not affected by the dietary PS. Milk fat content was increased by increasing AH particle size (p = 0.03) and decreased by SH substitution for a portion of AH (p<0.01). The numbers of total bacteria and cellulolytic species were not affected by PS of AH or by SH. F. succinogenes was the most abundant species in the rumen followed by R. albus and R. flavefaciens (p<0.01). This study showed that SH cannot replace the physically effective fiber in AH having either coarse or fine particle size. In diets containing SH, increasing of diet PS using coarse AH can maintain milk fat content similar to diets without SH. Particle size and peNDF content of diets did not affect the number of total or fibrolytic bacteria in the rumen.
Valizadeh, Armita,Ahmadzadeh, Ahmad,Saki, Ghasem,Khodadadi, Ali,Teimoori, Ali Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: B-cell chronic lymphocytic leukemia B (B-CLL), the most common type of leukemia, may be caused by apoptosis deficiency in the body. Adipose tissue-derived mesenchymal stem cells (AD-MSCs) as providers of pro-apoptotic molecules such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), can be considered as an effective anti-cancer therapy candidate. Therefore, in this study we assessed the role of tumor necrosis factor-producing mesenchymal stem cells oin apoptosis of B-CLL cells resistant to fludarabine-based chemotherapy. Materials and Methods: In this study, after isolation and culture of AD-MSCs, a lentiviral LeGO-iG2-TRAIL-GFP vector containing a gene producing the ligand pro-apoptotic with plasmid PsPAX2 and PMDG2 virus were transfected into cell-lines to generate T293HEK. Then, T293HEK cell supernatant containing the virus produced after 48 and 72 hours was collected, and these viruses were transduced to reprogram AD-MSCs. Apoptosis rates were separately studied in four groups: group 1, AD-MSCs-TRAIL; group 2, AD-MSCs-GFP; group 3, AD-MSCs; and group 4, CLL. Results: Observed apoptosis rates were: group 1, $42{\pm}1.04%$; group 2, $21{\pm}0.57%$; group 3, $19{\pm}2.6%$; and group 4, % $0.01{\pm}0.01$. The highest rate of apoptosis thus occurred ingroup 1 (transduced TRAIL encoding vector). In this group, the average medium-soluble TRAIL was 72.7pg/m and flow cytometry analysis showed a pro-apoptosis rate of $63{\pm}1.6%$, which was again higher than in other groups. Conclusions: In this study we have shown that tumor necrosis factor (TNF) secreted by AD-MSCs may play an effective role in inducing B-CLL cell apoptosis.
MEISAM VALIZADEH KIAMAHALLEH,CHAN IOU CHENG,SUHAIRI ABD SATA,SURANI BUNIRAN,SHARIF HUSSEIN SHARIF ZEIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.3
A novel ternary nanocomposite of nickel-manganese oxides/multi-walled carbon nanotubes (NMO/MWCNTs) coated with poly (3,4-ethylenedioxythiophene)(PEDOT) was prepared by chemical oxidation method. The filling of NMO particles inside MWCNTs and the uniform coating of NMO/MWCNTs with PEDOT intensified the capacitive behavior of MWCNTs. The lowest IR drop (0.1 V) and highest specific capacitance (SC) values of 526.55 F/g of NMO/MWCNTs/PEDOT imply it as highly efficient hybrid supercapacitor materials in 6 M KOH electrolyte.
MEISAM VALIZADEH KIAMAHALLEH,SHARIF HUSSEIN SHARIF ZEIN,GHASEM NAJAFPOUR,SUHAIRI ABD SATA,SURANI BUNIRAN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.2
Electrode materials are the most important factors to verify the properties of the electrochemical supercapacitor. In this paper, the storage principles and characteristics of electrode materials, including carbon-based materials, transition metal oxides and conducting polymers for supercapacitors are depicted in detail. Other factors such as electrode separator and electrolyte are briefly investigated. Recently, several works are conducted on application of multiwalled carbon nanotubes (MWCNTs) and MWCNTs-based electrode materials for supercapacitors. MWCNTs serve in experimental supercapacitor electrode materials result in specific capacitance (SC) value as high as 135 Fg-1. Addition of pseudocapacitive materials such as transition metal oxides and conducting polymers in the MWCNTs results in electrochemical performance improvement (higher capacitance and conductivity). The nanocomposites of MWCNTs and pseudocapacitive materials are the most promising electrode materials for supercapacitors because of their good electrical conductivity, low cost and high mass density.
A Particle-swarm-based Approach for Optimum Design of BELBIC Controller in AVR System
Sima Valizadeh,Mohammad-Reza Jamali,Caro Lucas 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
In this paper, Particle Swarm Optimization algorithm is applied to design an optimum intelligent controller based on brain emotional learning. BELBIC controller is tuned to improve the time domain parameters such as percent overshoot, steady state error, settling time and rise time of the step response of an Automatic Voltage Regulator. Also the convergence characteristic of fitness function averaged over the whole particles in each generation is investigated. PSO-BELBIC performance is compared with the classic PSO-PID controller.
Hadi Valizadeh,Parvin Zakeri-Milani,Peyman Nayyeri-Maleki,Saeed Ghanbarzadeh,Ahad Sheikhloo,Hossein Servat,Mahboob Nemati 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.1
The aim of this study was to evaluate thepharmacokinetics (PK) and bioequivalence (BE) of twometformin tablets. For in vitro evaluation, weight variation,assay and dissolution tests were performed. A randomized,single dose, two-period, cross over study in healthy malefasting volunteers was designed. A 2-week washout periodseparated the two periods. For analysis of PK parametersblood sampling was performed before and after drugadministration in various time points up to 12 h. Metforminconcentration in plasma was determined using a developedhigh performance liquid chromatography method. Bothformulations passed the assay, content uniformity, and dissolutiontests acceptance value. PK parameters, representingthe rate and the extent of metformin absorption were calculatedand analyzed for two formulations. The 90 % CIobtained by analysis of variance for the ratios of Cmax,AUC0–t, and AUC0–? were 92.14–110.95, 92.72–107.37and 89.42–110.23 % respectively, meeting the criteria forBE (80–125 %). Administration of a single dose of test andreference formulations did not result in statistically significantdifferences between in vitro and in vivo BE parametersin healthy Iranian male volunteers. Thus in the case of rateand extent of absorption the test and reference formulationswere considered bioequivalent.
Reza Valizadeh,Mahmood Moosazadeh,Kambiz Bahaadini,Leila Vali,Tahereh Lashkari,Mohammadreza Amiresmaili 질병관리본부 2016 Osong Public Health and Research Persptectives Vol.7 No.5
Objectives: To determine the prevalence of retinopathy and its associated factors in diabetic patients referred to a diabetes center in an Iranian city. Methods: This was a cross-sectional, descriptive-analytical study in which a researcher-made checklist was used to collect the data of patients with type 2 diabetes in 2015. The statistical population consisted of 11,770 health records of diabetic patients registered in a second-level diabetes center. Of the 11,770 health records, 206 records with the most complete data about patients with type 2 diabetes were selected through census method. Chi-square test and logistic regression through SPSS were used for data analysis. Results: In this study, 93/206 diabetic patients (45.1%) had retinopathy. Female sex, age over 60, lower education level, being housewife, family history of having diabetes, longer years of having the disease, and higher level of hemoglobin A1c (HbA1c) were associated with higher risk of retinopathy. However, the association was statistically significant only for the HbA1c level (p ≥ 0.05). Conclusion: According to this study, HbA1c level is a predictor of diabetes complications. Therefore, it is necessary for health authorities to improve diabetes management through different strategies to prevent complications to control blood sugar effectively.