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      • SCIESCOPUSKCI등재

        Performance of the Pigs Maintained in a Highland and Coastal Area of Minahasa Region, North Sulawesi

        Umboh, J.F.,Tulung, B. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.7

        Pigs respond to extreme temperature (very cold or hot) by physiological and nutritional adjustments. Yet little is known about the effects of different environmental temperature (thermoneutral in the highland area, and hot temperature in the coastal area) where pigs are maintained on the performance of the pigs. Ten pigs each (10 pairs of littermates) were assigned to two treatments (2 locations): highland area (control=CA) or coastal area (hot/heat stress=HS). Experimental design was Paired 't' test. HS pigs had higher average daily water intake (p<0.05) compared to CA pigs (6,05 vs 3.89 kg/d), CA pigs had higher feed intake compared to HS pigs (2.9 vs 1.95 kg/d, p<0,05). CA pigs had higher daily gain compared to HS pigs (0.72 vs 0.58 kg/d, p<0.05). Feed conversion was not significantly different between CA pigs and HS pigs. The digestibility of dry matter, N, Na, K, Mg, CI, Ca and P was not significantly affected by the treatments. High environmental temperature in the coastal area (heat stress) increased water intake, decreased voluntary feed intake and daily gain of the pigs. The results demonstrate that different environmental temperature in the coastal area (heat stress) and highland area (control) had no pronounced effect on digestibility of nutrients.

      • KCI등재

        The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia

        Jeanette Manoppo,Hilda Tasiringan,Audrey Wahani,Adrian Umboh,Max Mantik 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.5

        Purpose: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA). Methods: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L. Results: A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from 24.43±1.64 to 28.21±1.72 pg/L (P=0.000). Mean Ret-He level in group 2 changed from 24.31±1.42 to 27.03±2.14 pg/L (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05). Conclusion: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

      • SCOPUSKCI등재

        The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia

        Manoppo, Jeanette,Tasiringan, Hilda,Wahani, Audrey,Umboh, Adrian,Mantik, Max The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.5

        Purpose: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA). Methods: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L. Results: A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from $24.43{\pm}1.64$ to $28.21{\pm}1.72pg/L$ (P=0.000). Mean Ret-He level in group 2 changed from $24.31{\pm}1.42$ to $27.03{\pm}2.14pg/L$ (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05). Conclusion: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

      • SCIESCOPUSKCI등재

        Stress, Nutrition, and Intestinal Immune Responses in Pigs - A Review

        Lee, In Kyu,Kye, Yoon Chul,Kim, Girak,Kim, Han Wool,Gu, Min Jeong,Umboh, Johnny,Maaruf, Kartini,Kim, Sung Woo,Yun, Cheol-Heui Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.8

        Modern livestock production became highly intensive and large scaled to increase production efficiency. This production environment could add stressors affecting the health and growth of animals. Major stressors can include environment (air quality and temperature), nutrition, and infection. These stressors can reduce growth performance and alter immune systems at systemic and local levels including the gastrointestinal tract. Heat stress increases the permeability, oxidative stress, and inflammatory responses in the gut. Nutritional stress from fasting, antinutritional compounds, and toxins induces the leakage and destruction of the tight junction proteins in the gut. Fasting is shown to suppress pro-inflammatory cytokines, whereas deoxynivalenol increases the recruitment of intestinal pro-inflammatory cytokines and the level of lymphocytes in the gut. Pathogenic and viral infections such as Enterotoxigenic E. coli (ETEC) and porcine epidemic diarrhea virus can lead to loosening the intestinal epithelial barrier. On the other hand, supplementation of Lactobacillus or Saccharaomyces reduced infectious stress by ETEC. It was noted that major stressors altered the permeability of intestinal barriers and profiles of genes and proteins of pro-inflammatory cytokines and chemokines in mucosal system in pigs. However, it is not sufficient to fully explain the mechanism of the gut immune system in pigs under stress conditions. Correlation and interaction of gut and systemic immune system under major stressors should be better defined to overcome aforementioned obstacles.

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